Nature Search

miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala

The role of miRNAs in regulating brain stress response remains relatively unexplored. Here the authors show that miR-483-5p-mediated repression of Pgap2 in amygdala of male mice offsets the functional and behavioural consequences of stress.

Mariusz Mucha
Anna E. Skrzypiec
Robert Pawlak
ResearchOpen Access25 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12–q21

Nazneen Rahman
Laura Arbour
Steven A. Narod
Research01 Aug 1996
Nature Genetics

Volume: 13, P: 461-463
Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
Amendments and CorrectionsOpen Access27 Feb 2025
Nature

Volume: 639, P: E19
The familial Wilms' tumour susceptibility gene, FWT1, may not be a tumour suppressor gene

Nazneen Rahman
Laura Arbour
Michael R Stratton
Research26 Jun 1997
Oncogene

Volume: 14, P: 3099-3102
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
ResearchOpen Access09 Oct 2024
Nature

Volume: 635, P: 462-471
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes

Clinical boundaries between neurology and psychiatry hamper understanding of disorders with phenotypes that span these disciplines. In this Review, Peall et al. discuss rare genetic brain disorders with neurological and psychiatric phenotypes, and consider common underlying mechanisms that could be therapeutic targets.

Kathryn J. Peall
Michael J. Owen
Jeremy Hall
Reviews24 Nov 2023
Nature Reviews Neurology

Volume: 20, P: 7-21
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial

In an arm of a phase 1b trial, the combination of divarasib, a KRAS G12C inhibitor, and cetuximab, an epidermal growth factor receptor inhibitor, was well tolerated with an encouraging overall response rate of 62.5% in patients with KRAS G12C-positive colorectal cancer.

Jayesh Desai
Guzman Alonso
Sae-Won Han
ResearchOpen Access05 Dec 2023
Nature Medicine

Volume: 30, P: 271-278
Diverse alterations associated with resistance to KRAS(G12C) inhibition

Multiple treatment-emergent alterations appear in patients with advanced-stage cancer who were treated with a KRAS inhibitor.

Yulei Zhao
Yonina R. Murciano-Goroff
Piro Lito
Research10 Nov 2021
Nature

Volume: 599, P: 679-683
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer

In a prospective international cohort of 1,127 patients with non-small-cell lung cancer and ctDNA-guided therapy, ctDNA detection was associated with shorter survival, independently of clinicopathologic features and metabolic tumor volume.

Justin Jee
Emily S. Lebow
Bob T. Li
Research10 Nov 2022
Nature Medicine

Volume: 28, P: 2353-2363
DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

Elise L. V. Malavasi
Kyriakos D. Economides
J. Kirsty Millar
ResearchOpen Access06 Sept 2018
Translational Psychiatry

Volume: 8, P: 1-16
The International Spinal Cord Injury Pediatric Activity and Participation Basic Data Set

Miriam Hwang
Marika Augutis
M. J. Mulcahey
Research31 Oct 2019
Spinal Cord Series and Cases

Volume: 5, P: 1-7

Search

miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala

Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12–q21

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

The familial Wilms' tumour susceptibility gene, FWT1, may not be a tumour suppressor gene

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes

Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial

Diverse alterations associated with resistance to KRAS(G12C) inhibition

Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer

DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

The International Spinal Cord Injury Pediatric Activity and Participation Basic Data Set

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