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Showing 1–50 of 128 results

Advanced filters: Author: Kenji Takeuchi Clear advanced filters

Intragenic viral silencer element regulates HTLV-1 latency via RUNX complex recruitment

An intragenic open chromatin region in human T cell leukaemia virus type 1 functions as a transcriptional silencer and regulates transcriptional burst by recruiting the host transcription factor RUNX.

Kenji Sugata
Akhinur Rahman
Yorifumi Satou
ResearchOpen Access13 May 2025
Nature Microbiology

Volume: 10, P: 1447-1462
Immunological Suppression of the Occurrence of Spontaneous Mammary Tumours in C3H/He Mice

KENJI IRIE
REIKO F. IRIE
Research10 Sept 1971
Nature

Volume: 233, P: 133-134
Structured ionized winds shooting out from a quasar at relativistic speeds

Observations of a luminous quasar from the high-resolution spectrometer Resolve aboard XRISM revealed highly inhomogeneous wind structure outflowing from a supermassive black hole, which probably consists of up to a million clumps.

Marc Audard
Hisamitsu Awaki
Yerong Xu
Research14 May 2025
Nature

Volume: 641, P: 1132-1136
Orexin modulates behavioral fear expression through the locus coeruleus

Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus coeruleus which target lateral amygdala neurons and enhance fear expression and generalization.

Shingo Soya
Tohru M. Takahashi
Takeshi Sakurai
ResearchOpen Access20 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Serological Properties of Coxsackie A7 Virus

KENJI SODA
YASUO MORITSUGU
ISAMU TAGAYA
Research16 Jul 1966
Nature

Volume: 211, P: 315-316
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Anionic Polymerization of Vinylsilanes VI. Effects of N,N,N′,N′-Tetramethylethylenediamine on the Polymerization of Methyltrivinylsilane

Jun-ichi Oku
Masako Takahashi
Mikio Takaki
Research01 Jan 1994
Polymer Journal

Volume: 26, P: 79-84
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study

Mizuki Ohashi
Katsuyuki Miura
Hiroaki Ikezaki
Research14 Jan 2022
Hypertension Research

Volume: 45, P: 708-714
Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database

Takashi Miyano
Yudai Tamada
Kenji Takeuchi
ResearchOpen Access14 May 2025
Scientific Reports

Volume: 15, P: 1-12
Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury

The glycosaminoglycan chondroitin sulphate inhibits axon growth. Here the authors show that mice deficient in chondroitin sulphate biosynthesis have increased levels of heparan sulphate, which is more efficient than chondroitinase in supporting recovery from spinal cord injury.

Kosei Takeuchi
Nozomu Yoshioka
Michihiro Igarashi
ResearchOpen Access12 Nov 2013
Nature Communications

Volume: 4, P: 1-11
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Stereoregiilarity of Polyacrylonitrile by High Resolution ¹³C NMR Analysis

Kenji Kamide
Hitoshi Yamazaki
Kunio Hikichi
Research01 Dec 1985
Polymer Journal

Volume: 17, P: 1233-1239
Molecular Weight Determination of Comb-Like Polymers

Kenji Yokota
Tadamichi Hirabayashi
Yoshihito Inai
Research01 Jan 1994
Polymer Journal

Volume: 26, P: 105-108
Separation of Stereoisomers of Poly(methyl methacrylate) by High Performance Liquid Chromatography

Hisaya Sato
Masato Sasaki
Kenji Ogino
Research01 Dec 1989
Polymer Journal

Volume: 21, P: 965-969
Separation of Polybutadiene Depending on Isomeric Stuructures by High Performance Liquid Chromatography

Hisaya Sato
Masato Sasaki
Kenji Ogino
Research01 Jan 1991
Polymer Journal

Volume: 23, P: 23-27
Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells

Hirokazu Kotani
Kenji Takaishi
Yoshimi Takai
Research10 Apr 1997
Oncogene

Volume: 14, P: 1705-1713
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Myopia is a significant and increasing public health concern. Here Miyake et al. conduct a genome-wide association study and identify WNT7Bas a susceptibility gene across different ethnic groups, suggesting a possible role in the development of myopia.

Masahiro Miyake
Kenji Yamashiro
Nagahisa Yoshimura
Research31 Mar 2015
Nature Communications

Volume: 6, P: 1-9
Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis.

Nobuyuki Kakiuchi
Kenichi Yoshida
Seishi Ogawa
Research18 Dec 2019
Nature

Volume: 577, P: 260-265
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
A genome-wide association study on fish consumption in a Japanese population—the Japan Multi-Institutional Collaborative Cohort study

Taro Suzuki
Yasuyuki Nakamura
Toshiro Takezaki
Research07 Sept 2020
European Journal of Clinical Nutrition

Volume: 75, P: 480-488
Initiation Step of Radical Polymerization of Styrene in Various Non-Aromatic Solvents

Tohei Yamamoto
Jun Takeuchi
Mikiharu Kamachi
Research01 May 1994
Polymer Journal

Volume: 26, P: 587-592
Causes of Death in Patients with Severe Aortic Stenosis: An Observational study

Eri Minamino-Muta
Takao Kato
Takeshi Kimura
ResearchOpen Access07 Nov 2017
Scientific Reports

Volume: 7, P: 1-6
Impact of single dose of pegfilgrastim on peripheral blood stem cell harvest in patients with multiple myeloma or malignant lymphoma

Hideki Goto
Masashi Sawa
Takanori Teshima
ResearchOpen Access25 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Longitudinal association between posterior occlusal contact and dementia development in a large retrospective cohort study using a Japanese claims database

Takashi Miyano
Yudai Tamada
Kenji Takeuchi
ResearchOpen Access11 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Gender identification of the horsehair crab, Erimacrus isenbeckii (Brandt, 1848), by image recognition with a deep neural network

Yoshitaka Ueki
Kenji Toyota
Shin-ichi Satake
ResearchOpen Access13 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
Combined treatment with mesenchymal stem cells and therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy: a phase 1/2 randomized trial

Kazuko Wada
Akihito Takeuchi
Satoshi Kusuda
ResearchOpen Access10 May 2025
Scientific Reports

Volume: 15, P: 1-8
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Multiancestry genome-wide association analyses identify new risk loci for stroke and stroke subtypes. Fine mapping and bioinformatics analyses of these risk loci point to mechanisms not previously implicated in stroke pathophysiology.

Rainer Malik
Ganesh Chauhan
Martin Dichgans
Research12 Mar 2018
Nature Genetics

Volume: 50, P: 524-537
HIV-Tocky system to visualize proviral expression dynamics

A novel in vitro latency model (HIV-Tocky) suggests the multi-layered nature of HIV-1 post-integration latency at which latent proviruses with a history of expression showed features of stable latency in contrary to these lacking a history of expression.

Omnia Reda
Kazuaki Monde
Yorifumi Satou
ResearchOpen Access20 Mar 2024
Communications Biology

Volume: 7, P: 1-16
Main-Chain Flexibility and Side-Chain Crystallization of Widely Spaced Comb-Like Polymers

Tadamichi Hirabayashi
Tomoko Kikuta
Kenji Yokota
Research01 Aug 1988
Polymer Journal

Volume: 20, P: 693-698
A Novel Synthesis of Methyl Acrylate-α-d and ¹H Nuclear Magnetic Resonance Spectra of Its Alternating Copolymers

Kenji Yokota
Tadamichi Hirabayashi
Kensuke Takahashi
Research01 Mar 1980
Polymer Journal

Volume: 12, P: 177-181
A compact free-electron laser for generating coherent radiation in the extreme ultraviolet region

Free-electron lasers can produce powerful pulses of radiation at very short wavelengths, even in the hard-X-ray region. In general, however, they comprise facilities several kilometres in length. A 55-m-long laser could open up the technology to a broader range of researchers.

Tsumoru Shintake
Hitoshi Tanaka
Tetsuya Ishikawa
Research27 Jul 2008
Nature Photonics

Volume: 2, P: 555-559
Central control of bone remodeling by neuromedin U

Shingo Sato
Reiko Hanada
Shu Takeda
Research16 Sept 2007
Nature Medicine

Volume: 13, P: 1234-1240
Evolution of family systems and resultant socio-economic structures

Kenji Itao
Kunihiko Kaneko
ResearchOpen Access20 Oct 2021
Humanities and Social Sciences Communications

Volume: 8, P: 1-11
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer

Cancer cells develop resistance to tyrosine kinase inhibitors targeting EGFR. Here, the authors explore the mechanism of resistance to one such inhibitor - osimertinib - and find that resistance is caused by increased expression and activation of the IGF1 receptor and subsequent activation of the donwstream signalling pathway.

Rong Wang
Tadaaki Yamada
Seiji Yano
ResearchOpen Access14 Sept 2020
Nature Communications

Volume: 11, P: 1-14
Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension

Takao Saruta
Toshio Ogihara
Kihito Takahashi
Research01 Aug 2007
Hypertension Research

Volume: 30, P: 729-739
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
De novo inter-regional coactivations of preconfigured local ensembles support memory

The authors show that fear-memory-related cell-ensembles in the amygdala, hippocampus, and prefrontal cortex are inter-regionally co-activated in post-learning sleep. The co-activations are hosted by fast network oscillations and re-appear during recall.

Hiroyuki Miyawaki
Kenji Mizuseki
ResearchOpen Access11 Mar 2022
Nature Communications

Volume: 13, P: 1-21
Possible Synergic Effect of Angiotensin-I Converting Enzyme Gene Insertion/Deletion Polymorphism and Angiotensin-II Type-1 Receptor 1166A/C Gene Polymorphism on Ischemic Heart Disease in Patients with Kawasaki Disease

Ryuji Fukazawa
Tomoyoshi Sonobe
Shunichi Ogawa
Research01 Oct 2004
Pediatric Research

Volume: 56, P: 597-601
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Cervical spondylosis in paraplegic patients and analysis of the wheelchair driving action: A preliminary communication

Atsushi Kojima
Akio Nakajima
Kenji Koyama
Research01 Nov 1997
Spinal Cord

Volume: 35, P: 768-772
Kinetic Analysis of Engineered Polyhydroxyalkanoate Synthases with Broad Substrate Specificity

Ken′ichiro Matsumoto
Fumi Shozui
Seiichi Taguchi
Research28 Jan 2009
Polymer Journal

Volume: 41, P: 237-240
Preparation of Polyphenylenes with Higher Molecular Weights via Dehalogenative Polycondensation Using Magnesium and Aggregating Property of the Polymer in Solutions

Takakazu Yamamoto
Masahiro Abe
Kenji Kubota
Research01 Jul 2003
Polymer Journal

Volume: 35, P: 603-607
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Macrophages can be divided into two subsets, M1 and M2, which have crucial differences in their function. Akira and colleagues identify the histone demethylase Jmjd3 as a key factor in M2 development.

Takashi Satoh
Osamu Takeuchi
Shizuo Akira
Research22 Aug 2010
Nature Immunology

Volume: 11, P: 936-944
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Interleukin-17A is a potential therapeutic target predicted by proteomics for systemic sclerosis patients at high risk of pulmonary arterial hypertension

Yuuichi Ono
Akira Mogami
Yuko Kaneko
ResearchOpen Access27 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14

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