Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Kevin Haubrich Clear advanced filters

  • The RNA-binding ubiquitin E3 ligase TRIM25 plays a critical role in antiviral immunity. Here the authors identify key RNA-binding residues of TRIM25, link RNA binding to antiviral activity, reveal RNA structural and sequence preferences, and investigate binding to the viral genome.

    • Lucía Álvarez
    • Kevin Haubrich
    • Janosch Hennig
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Structure-based drug discovery of cereblon (CRBN)-recruiting protein degraders has been to date challenging due to limitations with current constructs for recombinant protein expression. In this work, the authors design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders.

    • Alena Kroupova
    • Valentina A. Spiteri
    • Alessio Ciulli
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • SH2 domains are challenging to target using small molecules. Here, the authors develop phosphotyrosine-based covalent ligands of the E3 ligase SOCS2 using structure-based design. A pro-drug approach yields cell active inhibitors that block SOCS2 substrate recruitment.

    • Sarath Ramachandran
    • Nikolai Makukhin
    • Alessio Ciulli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • NS1 of influenza A virus inhibits TRIM25 activity, which is an E3 ligase important for induction of the interferon response. Here, Koliopoulos et al. present structures of TRIM25 and NS1 and show how NS1 binding interferes with substrate recognition of TRIM25.

    • Marios G. Koliopoulos
    • Mathilde Lethier
    • Katrin Rittinger
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13