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A study presents a strategy based on human pluripotent stem cells for treating neurodegenerative disorders of the gastrointestinal tract.

Generalizable prediction of RNA secondary structure remains a challenge on unseen families. Here, the authors propose BPfold, which integrates a base pair motif library with thermodynamic energy into a deep learning framework, gaining superior accuracy and robustness over state-of-the-art methods.

Models of turbulent flows are often simulated in the laboratory, in sampling areas with dimensions <1 m. Here, the authors exploit a natural snowstorm to quantify turbulent flows, exploring the complex dynamics of the atmospheric boundary layer around a 2.5-MW utility-scale wind turbine.

The authors achieve precise strain control of freestanding SrTiO₃ membranes, enabling reversible ferroelectric transition. In-situ X-ray absorption spectroscopy unveils classical-to-quantum crossover in ferroelectric phase transition at low temperatures.

High-resolution STM/STS visualizes the fractionalization of flat moiré bands into discrete Hofstadter subbands in moiré graphene near the predicted second magic angle, and experimentally establishes several fundamental properties of the fractal Hofstadter energy spectrum.

The final analysis from the phase 3 IMpassion031 trial shows that adding atezolizumab to chemotherapy for stage II/III triple-negative breast cancer is associated with favorable long-term outcomes, with circulating tumor DNA clearance correlating with therapy response.

The status of immune cells within human pancreatic lymphatic tissues during the onset and progression of type 1 diabetes (T1D) is underexplored. Here, by flow cytometry and CITEseq, the authors profile pancreatic, mesenteric, and splenic lymphatic tissues from individuals with varying clinical statuses and identify tissue-specific immune responses associated with T1D autoimmunity.

Dynamic control of light flow in 2D synthetic landscapes is emerging as a valuable tool for the development of light-based technologies. Here the authors harness time-dependent non-Hermitian Hamiltonians to demonstrate dynamic control over the skin effect.

Acquiring biomarkers from blood or sweat is limited by invasiveness or biofouling. Skin gas emissions bypass these issues, offering rich biosignals. Authors present passive sensing strategies capturing water vapor (Sweat rate), CO2, and VOCs, enabling real-time tracking of physiological changes.

Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Here the authors show that IL17A-producing NKp44- group 3 innate lymphoid cells accumulate in FAP duodenal tissue and are associated with duodenal adenoma formation in patients with FAP.

Bat influenza viruses use MHCII, not sialic acids, for entry. Using high-resolution microscopy. on live cells, the authors show at the nanoscale that viral particles attach to clusters of MHCII. and attract additional molecules to the attachment site.

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Breather solitons can be found in both physical and biological nonlinear systems. Here, Yuet al. demonstrate this type of soliton in silicon and silicon nitride microresonators, which advances the understanding of soliton-based comb-generation in microresonators.

Strong electron–electron interactions in magic-angle twisted bilayer graphene can fundamentally change the topology of the system’s flat bands, producing a hierarchy of strongly correlated topological insulators in modest magnetic fields.

Neurons receive their input in three dimensions via their dendrites, but how electrical activity in dendrites is organized is unknown. Here, the authors work out the distinct rules that govern activity across this 3D structure in different brain states.

A cavity that can switch between lasing and anti-lasing could inspire a new design of optical modulator.

Prediabetics have an increased risk of type 2 diabetes. In this parallel-design, randomized controlled trial, the authors show improvements in metabolic health in a prediabetes population consuming a legume-rich diet, which are mediated through favorable changes in gut microbiome.

Chung et al. show that total-body dynamic positron emission tomography can allow non-invasive quantitative imaging of the molecular permeability of the human blood-brain barrier using various molecular radiotracers.

High-throughput automated synthesis is used to investigate the crystallization behaviour of two-dimensional (2D) halide perovskites (HPs) based on a bulky ligand cation, 3,3-diphenylpropylammonium. The solution-processed 2D HP flakes realize a moiré superlattice, indicating the formation of a twisted 2D stack via self-assembly action.

Crystal dissolution has been predominately viewed as a process of ion-by-ion detachment into a surrounding solvent. Here, the authors report an alternative mechanism of dissolution by particle detachment.

Nanoscale patterning methods based on self-assembly promise to revolutionize the fabrication of high-tech devices, but suffer from a limited number of possible lattice symmetries. Here, the authors use a laser zone annealing technique to pattern block copolymers into any 2D mesh motif they desire.

The nanometre length scale of plasmonic structures leads to vibrational dynamics at high frequencies, which could be exploited for sensitive optical detectors. O'Brien et al. show that they can detect spatial properties of phonon modes in multimodal plasmonic structures, revealing complex nanomechanical dynamics.

Microfluidic experiments reveal that surface-attached Pseudomonas aeruginosa cells directly sense differences in chemical concentration across the length of their cell bodies to guide pili-based chemotaxis.

Electric fields in the solar atmosphere are not studied as widely as the magnetic fields mainly due to small, short living signals. Here, the authors show measurement of an electric field associated with magnetic diffusion triggering an energetic event in the solar atmosphere.

Antiferromagnets offer the potential for higher speed and density than ferromagnetic materials for spintronic devices. Here, Reimers et al study the ___domain structure of CuMnAs, demonstrating the role of defects in stabilizing the ___location and orientation of antiferromagnetic ___domain walls.

In a comprehensive dataset from 3,652 patients across 20 centers in eight countries, an ultrasound-based AI model shows robust performance across centers, ultrasound systems, 58 histological diagnoses and patient age groups and reduced referral to experts by 63% in a retrospective triage simulation.

Activated carbon has been widely used for PFAS adsorption, but this method generates secondary solid wastes. The flash Joule heating approach realizes mineralization of PFAS and generation of useful flash graphene in waste granular activated carbon.

A conserved feature of metazoan meiosis is that it occurs in a syncytium. Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meiotic progression and fertility in male mice.

The structures of 1,5-polyol-containing polyketide-derived natural products are notoriously difficult to determine using spectroscopic techniques due to spectral overlap and chemical shift degeneracy. Now, a blueprint for the structure determination of this class of natural products is reported, combining ultra-high-resolution NMR spectroscopy and synthesis to unveil the correct structure of caylobolide A.

Martian dust is globally enriched in S and Cl and has a distinct mean S:Cl ratio. Here the authors identify that the largest potential source region for Martian dust based on analysis of elemental abundance data may be the Medusae Fossae Formation.

Recent research efforts have aimed at discovering thermoelectric materials with high efficiency in the middle-low temperature range, where a majority of waste heat is lost to the ambient. Here, the authors discover colossal Seebeck coefficient values in metallic copper selenide from 340 K to 400 K.

Spectroscopy from the JWST Advanced Deep Extragalactic Survey of a galaxy at redshift 13 shows a singular, bright emission line identified as Lyman-α, suggesting the onset of reionization only 330 Myr after the Big Bang.

Recently, disordered or granular superconductors have gained attention for their applications in quantum devices. Here the authors report a reproducible method to fabricate high-impedance granular Al resonators, followed by integration with quantum dot devices, achieving record hole-photon coupling strength.

Single-walled carbon nanotubes can be modified into bright and biocompatible agents for high resolution whole-animal imaging at wavelengths in the 1100–1700 nm region.

An important role is played by thermal effects in the electrically driven insulator-to-metal transition in V₂O₃.

Spontaneous fluctuations in brain activity exhibit complex spatiotemporal patterns across animal species. Here the authors show that sensory-motor regions and spatial heterogeneity in excitation-inhibition balance might shape multi-stability in brain dynamics.

Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultrasensitive platform for RNA imaging, which features RNA tags that recruit light-emitting luciferase fragments.

Field-driven insulator-to-metal transition and associated colossal magnetoresistance have been reported in the magnetic nodal-line semiconductor Mn₃Si₂Te₆. Gu et al. measure infrared response across magnetic ordering and the transition, revealing a weakly metallic state instead of a traditional metallic state.

Alterations of therapeutic pressures have been shown to affect clonal evolution of resistance. Here, the authors conducted a single arm, phase 2 trial consisting of alternating osimertinib and gefitinib in non-small cell lung cancer, and found ctDNA dynamics were predictive of response.

Upgrading biogas to valuable solid carbon can potentially lead to negative CO₂ emissions with long-term carbon storage but faces substantial thermodynamic and kinetic limits using a single reactor. Tandem strategies can decouple reactions into tandem reactors, integrate non-equilibrium processes and identify synergistic catalytic sites to enhance carbon nanofiber production.