During mitosis, the two copies of each chromosome pair are held together by cohesin. Three subunits of cohesin form a ring structure and it has been proposed that the sister chromatids are tethered together by being encircled by cohesin rings. This paper provides the most direct evidence to date that cohesin rings topologically entrap two DNA molecules.
- Christian H. Haering
- Ana-Maria Farcas
- Kim Nasmyth