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Scientific Reports (13)
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Showing 1–50 of 62 results

Advanced filters: Author: Koichi Akashi Clear advanced filters

Clonal origin of Epstein-Barr virus-infected T/NK-cell subpopulations in chronic active Epstein-Barr virus infection

Shouichi Ohga
Masataka Ishimura
Toshiro Hara
ResearchOpen Access09 Mar 2010
Nature Precedings

P: 1
Asynchronous Rhythm of Steroidogenic Factor 1 and Period Homolog 2 mRNA Expression in Mouse Y1 Adrenocorticol Tumor Cells

Kenji Ohe
Kouichirou Sonoda
Toshihiko Yanase
ResearchOpen Access09 Jun 2010
Nature Precedings

P: 1
Evaluation of clinical biomarkers for differential diagnosis of intravascular lymphoma and Still’s disease

Takahiro Shima
Yusuke Yamauchi
Koji Kato
ResearchOpen Access04 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease

Idiopathic multicentric Castleman disease (CD) is a rare and potentially fatal lymphoproliferative disorder. Authors here establish a mouse xenotransplantation model of the “not otherwise specified” subtype of the disease and show that the chemokine CXCL13 plays a pivotal role in the pathogenesis and likely produced by peripheral helper cells, which expand upon engraftment.

Takuya Harada
Yoshikane Kikushige
Kazuyuki Yoshizaki
ResearchOpen Access31 Oct 2023
Nature Communications

Volume: 14, P: 1-13
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Koichi Akashi
David Traver
Irving L. Weissman
Research09 Mar 2000
Nature

Volume: 404, P: 193-197
The aging of hematopoietic stem cells

Sean J. Morrison
Antoni M. Wandycz
Irving L. Weissman
Research01 Sept 1996
Nature Medicine

Volume: 2, P: 1011-1016
Hematopoietic developmental pathways: on cellular basis

H Iwasaki
K Akashi
Reviews15 Oct 2007
Oncogene

Volume: 26, P: 6687-6696
Spatial dynamics of CD39⁺CD8⁺ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer

Immune checkpoint blockade (ICB) benefits esophageal squamous cell cancer, but the immune cell mediators remain unclear. Here the author show, by imaging mass cytometry, that CD39⁺CD8⁺ exhausted cells are present abundantly in both tertiary lymphoid tissue and tumor and correlate with responses to ICB.

Kenro Tanoue
Hirofumi Ohmura
Eishi Baba
ResearchOpen Access19 Oct 2024
Nature Communications

Volume: 15, P: 1-18
KK2845, a PBD dimer-containing antibody-drug conjugate targeting TIM-3-expressing AML

Jian Zou
Haruka Kinosada
Hidetaka Satou
ResearchOpen Access22 May 2025
Leukemia

P: 1-9
Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

Motonari Kondo
David C. Scherer
Irving L. Weissman
Research21 Sept 2000
Nature

Volume: 407, P: 383-386
Distinct leukemogenic mechanism of acute promyelocytic leukemia based on genomic structure of PML::RARα

Mariko Minami
Teppei Sakoda
Yoshikane Kikushige
Research20 Feb 2025
Leukemia

Volume: 39, P: 844-853
Generation of functional oocytes from male mice in vitro

Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring after fertilization.

Kenta Murakami
Nobuhiko Hamazaki
Katsuhiko Hayashi
Research15 Mar 2023
Nature

Volume: 615, P: 900-906
Posttransplant cyclophosphamide in unrelated and related peripheral blood stem cell transplantation from HLA-matched and 1 allele mismatched donor

Junichi Sugita
Takashi Kuroha
Takanori Teshima
Research19 Dec 2023
Bone Marrow Transplantation

Volume: 59, P: 344-349
Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy

Tomoko Nomiyama
Daiki Setoyama
Yuya Kunisaki
ResearchOpen Access11 Mar 2025
Leukemia

Volume: 39, P: 983-987
Syntheses of Poly(ethylene oxide) Macromonomers Carrying Tertiary Amine and Quaternary Ammonium End Groups

Takamichi Senyo
Yuji Atago
Koichi Ito
Research01 Jun 2003
Polymer Journal

Volume: 35, P: 513-518
Poly(ethylene oxide) Macromonomers IX. Synthesis and Polymerization of Macromonomers Carrying Styryl End Groups with Enhanced Hydrophobicity

Dongri Chao
Shinichi Itsuno
Koichi Ito
Research01 Sept 1991
Polymer Journal

Volume: 23, P: 1045-1052
Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells

Clonal dynamics and selection have not been fully understood in patient-derived xenografts (PDX) of acute myeloid leukemia (AML). Here, the authors generate 160 AML-PDX models to track the clonal dynamics of primary and relapsed AML, and find selectively enriched subclones that are associated with resistance to therapy.

Naomi Kawashima
Yuichi Ishikawa
Hitoshi Kiyoi
ResearchOpen Access25 Mar 2022
Nature Communications

Volume: 13, P: 1-11
Mouse common lymphocyte progenitors: correcting a misconception

Motonari Kondo
Reina E. Mebius
Irving L. Weissman
Correspondence01 Feb 2002
Nature Reviews Immunology

Volume: 2, P: 140
Low-dose anti-thymocyte globulin for GVHD prophylaxis in HLA-matched allogeneic peripheral blood stem cell transplantation

Souichi Shiratori
Junichi Sugita
Mine Harada
Research05 Jul 2020
Bone Marrow Transplantation

Volume: 56, P: 129-136
Reduced dose of posttransplant cyclophosphamide in HLA-haploidentical peripheral blood stem cell transplantation

Junichi Sugita
Tomohiko Kamimura
Takanori Teshima
Research24 Sept 2020
Bone Marrow Transplantation

Volume: 56, P: 596-604
Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus

Miki Nakano
Masahiro Ayano
Hiroaki Niiro
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-8
Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin

Kenji Tsuchihashi
Hitoshi Kusaba
Eishi Baba
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-6
Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis

Shoichi Fukui
Ayako Kuwahara-Takaki
Atsushi Kawakami
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-8
Myeloablative and reduced-intensity conditioning in HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide

Junichi Sugita
Yusuke Kagaya
Takanori Teshima
Research07 Aug 2018
Bone Marrow Transplantation

Volume: 54, P: 432-441
Discrete genetic subtypes and tumor microenvironment signatures correlate with peripheral T-cell lymphoma outcomes

Yasuhito Suehara
Kana Sakamoto
Mamiko Sakata-Yanagimoto
ResearchOpen Access31 Mar 2025
Leukemia

Volume: 39, P: 1184-1195
Compensation for intracellular environment in expression levels of mammalian circadian clock genes

Ritsuko Matsumura
Akihiko Okamoto
Makoto Akashi
ResearchOpen Access07 Feb 2014
Scientific Reports

Volume: 4, P: 1-6
Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

Adipocyte differentiation is accompanied by large scale changes in the actin cytoskeleton. Here, Nobusue et al.show that binding to G-actin sequesters the transcriptional coactivator MKL1 in the cytoplasm, and triggers differentiation by inducing the expression of pro-adipogenic transcription factor PPARγ.

Hiroyuki Nobusue
Nobuyuki Onishi
Koichiro Kano
Research26 Feb 2014
Nature Communications

Volume: 5, P: 1-12
Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

Diabetes can be caused by viral infections in humans and some inbred mice, suggesting genetic predisposition. Here the authors show that mutations in Tyk2 gene underlie susceptibility to virus-induced diabetes in mice, due to Tyk2requirement for antiviral response in insulin-producing cells.

Kenichi Izumi
Keiichiro Mine
Seiho Nagafuchi
ResearchOpen Access07 Apr 2015
Nature Communications

Volume: 6, P: 1-10
C/EBPβ is required for 'emergency' granulopoiesis

Hideyo Hirai
Pu Zhang
Daniel G Tenen
Research04 Jun 2006
Nature Immunology

Volume: 7, P: 732-739
Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells

Studies on neural stem and progenitor cells have shown they may be useful in treating spinal cord injuries, but the results are variable. Kumamaruet al.transplant these cells in injured spinal cords of mice, and find that their therapeutic properties are dynamically altered depending on their environment.

Hiromi Kumamaru
Yasuyuki Ohkawa
Seiji Okada
Research16 Oct 2012
Nature Communications

Volume: 3, P: 1-13
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

Fumihiko Ishikawa
Shuro Yoshida
Leonard D Shultz
Research21 Oct 2007
Nature Biotechnology

Volume: 25, P: 1315-1321
Objective quantification of pre-CAR-T EEG abnormalities for ICANS prognosis: insights from GTE scoring

Hidetaka Nakagaki
Takuji Yamauchi
Koji Kato
Correspondence28 Apr 2025
Bone Marrow Transplantation

P: 1-3
The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells

Tatsuya Terasaki
Yuichiro Semba
Takahiro Maeda
Research11 Jul 2024
Leukemia

Volume: 38, P: 1918-1928
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

Frank Rosenbauer
Bronwyn M Owens
Daniel G Tenen
Research27 Nov 2005
Nature Genetics

Volume: 38, P: 27-37
Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis

How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent histone acetylation of master adipogenic gene enhancers, while SETD5 degradation triggers enhancer hyperacetylation and transition to active state.

Yoshihiro Matsumura
Ryo Ito
Juro Sakai
ResearchOpen Access02 Dec 2021
Nature Communications

Volume: 12, P: 1-19
Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

Nami McCarty
Silke Paust
Harvey Cantor
Research19 Dec 2004
Nature Immunology

Volume: 6, P: 65-72
Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Yuma Sakamoto
Takuaki Yamamoto
Shiro Ikegawa
ResearchOpen Access08 Nov 2017
Scientific Reports

Volume: 7, P: 1-12
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Genome-wide analysis in 212,453 Japanese individuals identifies loci associated with 42 diseases. Comparative analysis with European populations identifies East Asian–specific associations.

Kazuyoshi Ishigaki
Masato Akiyama
Yoichiro Kamatani
Research08 Jun 2020
Nature Genetics

Volume: 52, P: 669-679
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1

Frank Rosenbauer
Katharina Wagner
Daniel G Tenen
Research16 May 2004
Nature Genetics

Volume: 36, P: 624-630
Predictive impact of C-reactive protein to albumin ratio for recurrent or metastatic head and neck squamous cell carcinoma receiving nivolumab

Kenro Tanoue
Shingo Tamura
Eishi Baba
ResearchOpen Access02 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis

POT1a is crucial for osteogenic-differentiation from mesenchymal stem cells (MSCs), and the ability to support B-lymphopoiesis is diminished in bone marrow microenvironments with POT1a deletion in MSCs

Kentaro Nakashima
Yuya Kunisaki
Fumio Arai
ResearchOpen Access29 Sept 2023
Communications Biology

Volume: 6, P: 1-14
Diverse pathological lesions of primary aldosteronism and their clinical significance

Koshiro Nishimoto
Hironobu Umakoshi
Chiba Yoshiro
ResearchOpen Access12 Jan 2021
Hypertension Research

Volume: 44, P: 498-507
Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation

Takeshi Sugio
Naoyuki Uchida
Koji Kato
Research18 Jan 2024
Bone Marrow Transplantation

Volume: 59, P: 466-472
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution

Sakurako Suma
Yasuhito Suehara
Mamiko Sakata-Yanagimoto
ResearchOpen Access27 Nov 2023
Leukemia

Volume: 38, P: 340-350
Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance

Fumihiko Nakao
Kiyoko Setoguchi
Takahiro Maeda
Research27 Mar 2023
Leukemia

Volume: 37, P: 1028-1038
C-reactive protein/albumin ratio is the most significant inflammatory marker in unresectable pancreatic cancer treated with FOLFIRINOX or gemcitabine plus nab-paclitaxel

Tsuyoshi Shirakawa
Akitaka Makiyama
Eishi Baba
ResearchOpen Access31 May 2023
Scientific Reports

Volume: 13, P: 1-12
Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism

Regarding Japanese primary aldosteronism, the low, intermediate, and high renin change groups (classified based on the response of renin to mineralocorticoid antagonist treatment) had CVD incidence of 2.1%, 0.5%, and 3.7%, respectively, during the 5-year study period.

Motoko Nomura
Isao Kurihara
Chiba Yoshiro
Research28 Jun 2022
Hypertension Research

Volume: 45, P: 1476-1485
Targeting leukemia-specific dependence on the de novo purine synthesis pathway

Takuji Yamauchi
Kohta Miyawaki
Takahiro Maeda
Research03 Aug 2021
Leukemia

Volume: 36, P: 383-393
Efficacy of prophylactic letermovir for cytomegalovirus reactivation in hematopoietic cell transplantation: a multicenter real-world data

Yasuo Mori
Fumiaki Jinnouchi
Toshihiro Miyamoto
Research02 Nov 2020
Bone Marrow Transplantation

Volume: 56, P: 853-862
Transfer learning efficiently maps bone marrow cell types from mouse to human using single-cell RNA sequencing

Patrick Stumpf et al. use a machine learning technique called transfer learning to compare bone marrow cell-type information between mice and humans, based on single-cell RNA-seq data. Using their model, they identify aspects of cellular expression profiles that transfer and those that don’t, which can be used to understand when mouse models of human disease are appropriate.

Patrick S. Stumpf
Xin Du
Ben D. MacArthur
ResearchOpen Access04 Dec 2020
Communications Biology

Volume: 3, P: 1-11

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