Search

This study reveals that global adoption of mass timber products can expand forestland, increase carbon stocks in forest and wood products, and decrease life-cycle greenhouse gas emissions.

Through multimodal analyses of human cardiac tissues across different ages, Fan, Zheng, Zhan, Xu, Liu and colleagues reveal that RNA-binding protein ARID5A drives inflammaging by stabilizing the MAVS mRNA and activating the NF-κB–TBK1 pathway, and show that inactivating myocardial ARID5A attenuates cardiac senescence and functional decline.

The exact role of the degenerate nucleotide-binding site in a heterodimeric ABC transporter is unclear. Here, authors identify a mycobacterial isoniazid efflux pump, capture its asymmetric intermediate states and reveal mechanism of this transporter mediated by the degenerate site.

To increase the efficiency, brightness and stability of next-generation light-emitting diodes (LEDs), the microstructure of CsPbI_3-xBr_x metal-halide perovskite, a good pure-red emitter, was altered to fix hole leakage, which was identified as decreasing efficiencies in overworked LEDs.

In a randomized controlled trial involving patients with heart failure with reduced ejection fraction, treatment with Qiliqiangxin, a traditional Chinese medicine derived from 11 types of plants, decreased the incidence of cardiac events, as compared to placebo.

Regio- and stereoselective transition-metal catalysed hydrosilylation of terminal allenes to access (E)-allylsilanes are challenging organic transformations. Herein, the authors synthesize (E)-allylsilanes via copper-catalyzed hydrosilylation of terminal allenes.

One challenge for spin-based electronics is the controlled and reliable switching of magnetization without magnetic fields. Here, Liu et al investigate a variety of compositions of CoPt, and determine the specific composition to maximize switching performance, potentially simplifying device design.

Here, the authors describe the mechanisms by which innate immune cells contribute to acute kidney injury, the transition from acute kidney injury to chronic kidney disease, and the progression of chronic kidney disease. They also discuss potential therapeutic strategies that target the innate immune system.

Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing Granzyme K, a complement-activating tryptase, which is a potential therapeutic target.

Nodal line semimetals have been observed in three-dimensional materials but are missing in two-dimensional counterparts. Here, Feng et al. report two-dimensional Dirac nodal line fermions protected by mirror reflection symmetry in monolayer Cu₂Si.

Tubulointerstitial inflammation occurs frequently in acute kidney injury (AKI), and Mφ autophagy is a known contributor to inflammation-related diseases. Here, Yuan et al. show that Mφ autophagy deficiency induces systemic inflammation, impairs mitochondria, and worsens kidney injury in AKI mice.

Understanding the mutation landscape of cancer may enable the development of more targeted therapies. Here, the authors sequence a panel of genes in a large Asian cohort and compare to American cohorts and find 64% of the Asian patients have actionable mutations.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Spin-polarized edge states in two-dimensional materials hold promise for spintronics and quantum computing applications. Here, the authors reveal the orientation-selective spin-polarized edge states along the Ni-terminated edges in monolayer NiI₂ islands.

This study introduces a ChickenGTEx atlas of regulatory variants across 28 tissues and illustrates its utility in deciphering association signals for 39 complex traits in chickens.

Mental stress is well known to cause cardiovascular disease. Here, the authors show that an imbalance in RBM24-S181 phosphorylation impairs cardiac translation of APOE, leading to cardiac contractile dysfunction, atrial fibrillation, fibrosis, and sudden death under psychological stress.

The physiological degradation of programmed-death ligand 1 is reduced by the palmitoylation of its intracellular ___domain, and this process can be inhibited to promote T-cell immunity against tumours.

RNA processing by alternative polyadenylation (APA) can result in 3′UTR diversity and regulation of target RNA function. Here the authors survey APA in viral infection of macrophages.

The application of pressure effectively suppresses the spin–charge order in trilayer nickelate La₄Ni₃O_10−δ single crystals, leading to the emergence of superconductivity.

Here the authors show that DNA damage induced RNA m5C in R-loops competes with PARP1- mediated PARylation in transcribed genomes to promote cell survival which could be targeted be in cancer therapy.

An analysis of 140 floras from China reveals that high species diversity exists in granite and mixed landforms, while low species diversity is found in karst, Danxia, and desert landforms. Based on these findings, the authors provide new clues for understanding the assembly and differentiation of mountain floras, highlighting the role of bedrock and landform processes.

Here, the authors report the engineering, structural and biological characterization of synthetic nanobodies (sybodies) that display potent therapeutic activity against SARS-CoV-2 infection in animal models via targeting the virus receptor-binding ___domain.

In support of an evolutionary model that links distaste, disgust and socio-moral processes, Gan et al. use functional magnetic resonance imaging to develop a neuromarker for subjective core disgust that generalizes to oral distaste and unfairness.

Aberrant expression of Synaptonemal complex protein 2 (SYCP2) in breast and ovarian cancers is associated with resistance to drugs targeting the DNA damage response. Here the authors show that SYCP2 confers drug resistance by promoting R-loop formation during transcription-coupled homologous recombination.

The realization of heavy-fermion physics in van der Waals materials with d-electrons has attracted attention recently. Here the authors present evidence for a quasi-1D Kondo lattice in monolayer NbSe₂, driven into a stripe phase by Se-deficient line defects created during growth.

The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous outbreaks and that the genetic diversity of the virus has increased substantially, with the emergence of several novel lineages.

The Zhurong rover identified polygonal terrain at a depth of 35 m under Utopia Planitia on Mars. This finding suggests that the mid-latitudinal region experienced a cold and wet environment near the freezing point of water around the Hesperian–Amazonian transition, possibly induced by Mars’s high obliquity.

Ultra-low temperature resistant adhesives are desirable for their potential use in polar areas or space exploration. Here, the authors develop a low-temperature tolerant adhesive with high adhesion strength in a wide tolerable temperature range and long-lasting adhesion effect that exceeds the classic commercial hot melt adhesives.

In the field of plant genome engineering, new nucleases with improved editing efficiency and alterative PAM requirements are needed. Here, the authors report a probiotic sourced CRISPR-LrCas9 system with similar PAM requirement to Cas12a and show its high efficiencies in various genome editing applications.

Multi-omics characterization of ZIKA virus–infected mouse brains reveals metabolic reprogramming events, including dysregulation of NAD⁺ metabolism, the correction of which is shown to alleviate ZIKA virus–induced microcephaly.

The overall efficiency of free-triplet generation from intramolecular singlet fission is limited by the efficiency of the dissociation of spatially adjacent triplet pairs. Now, using transient magneto-optical spectroscopy, it has been shown that this limitation can be overcome by promoting a pathway mediated by spatially separated triplet pairs in tetracene trimers and tetramers.

Various methods have been proposed to identify synthetic lethality interactions, but selective treatment opportunities for various tumors have not yet been explored. Here, the authors develop the Synthetic Lethality Knowledge Graph webserver (SLKG, http://www.slkg.net) to explore the comprehensive tumor therapy landscape and uncover cancer-specific susceptibilities based on the principle of synthetic lethality.