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Advanced filters: Author: Laszlo A. Groh Clear advanced filters

A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation

The long noncoding RNA AMANZI downregulates IL-1β expression and trained immunity by inducing IL-37 transcription via long-range chromatin contacts. The common variant rs16944 present in AMANZI modulates proinflammation or immunosuppression risk.

Ezio T. Fok
Simone J. C. F. M. Moorlag
Musa M. Mhlanga
Research13 Dec 2023
Nature Genetics

Volume: 56, P: 85-99
Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

A nanoparticle integrating a fusion protein of apolipoprotein A1 and interleukin-4 and that targets myeloid-cell-rich haematopoietic organs resolves immunoparalysis in ex vivo and in vivo models of sepsis.

David P. Schrijver
Rutger J. Röring
Willem J. M. Mulder
ResearchOpen Access08 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 1097-1112

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A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation

Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

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