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Showing 1–3 of 3 results
Advanced filters: Author: Leishu Lin Clear advanced filters

  • This study reports the cryo-EM structure of full-length MICAL1 in its autoinhibited conformation, unveiling the molecular mechanisms of tail-mediated inhibition and Rab-binding-mediated relief that regulate MICAL’s activity in F-actin disassembly.

    • Leishu Lin
    • Jiayuan Dong
    • Zhiyi Wei
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • This study shows that CLASP2, a microtubule-stabilizing protein, regulates microtubule targeting via a tunable condensate interaction, offering mechanistic insights into the dynamic organization of multi-condensates in response to cellular signals.

    • Xuanyan Jia
    • Leishu Lin
    • Cong Yu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • This study reveals the high-resolution cryo-EM structure of autoinhibited myosin VI, offering insights into cargo-mediated activation of this unique myosin motor and advancing our understanding of motor activity control in the myosin superfamily.

    • Fengfeng Niu
    • Lingxuan Li
    • Zhiyi Wei
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13