Nature Search

Clonal tracing with somatic epimutations reveals dynamics of blood ageing

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.

Michael Scherer
Indranil Singh
Lars Velten
ResearchOpen Access21 May 2025
Nature

P: 1-10
Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells

Single-cell analyses of immune cells from patients with pathogenic, single large-scale mitochondrial DNA (mtDNA) deletions including Pearson syndrome describe heteroplasmy dynamics consistent with purifying selection, as well as T-cell state-specific regulatory mechanisms and metabolic vulnerabilities.

Caleb A. Lareau
Sonia M. Dubois
Leif S. Ludwig
Research29 Jun 2023
Nature Genetics

Volume: 55, P: 1198-1209
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

Let-7 microRNA (miRNA) and its target gene lin-28 regulate pluripotency. A second Let-7 target, lin-41, controls miRNA function in stem cells by regulating the turnover of the miRNA effector Argonaute2 through its ubiquitin ligase activity.

Agnieszka Rybak
Heiko Fuchs
F. Gregory Wulczyn
Research08 Nov 2009
Nature Cell Biology

Volume: 11, P: 1411-1420
Small-molecule-induced polymerization triggers degradation of BCL6

Binding of the small molecule BI-3802 to the oncogenic transcription factor B cell lymphoma 6 (BCL6) induces polymerization of BCL6, leading to its ubiquitination by SIAH1 and proteasomal degradation.

Mikołaj Słabicki
Hojong Yoon
Benjamin L. Ebert
Research18 Nov 2020
Nature

Volume: 588, P: 164-168
Mitochondrial genetics through the lens of single-cell multi-omics

This Review discusses emerging technologies and insights from mitochondrial DNA variant profiling obtained by single-cell multi-omics, demonstrating how the powerhouse of the cell may record clonal lineages and contribute to disease heterogeneity.

Lena Nitsch
Caleb A. Lareau
Leif S. Ludwig
Reviews01 Jul 2024
Nature Genetics

Volume: 56, P: 1355-1365
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Agnieszka Rybak
Heiko Fuchs
F. Gregory Wulczyn
Research06 Jul 2008
Nature Cell Biology

Volume: 10, P: 987-993
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility

This protocol for concomitant high-throughput mitochondrial DNA genotyping and accessible chromatin profiling of single cells allows paired analysis of clonal relationships and cell states.

Caleb A. Lareau
Vincent Liu
Leif S. Ludwig
Protocols15 Feb 2023
Nature Protocols

Volume: 18, P: 1416-1440

Search

Clonal tracing with somatic epimutations reveals dynamics of blood ageing

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

Small-molecule-induced polymerization triggers degradation of BCL6

Mitochondrial genetics through the lens of single-cell multi-omics

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility

Search

Quick links

Search

Filter By:

Clonal tracing with somatic epimutations reveals dynamics of blood ageing

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

Small-molecule-induced polymerization triggers degradation of BCL6

Mitochondrial genetics through the lens of single-cell multi-omics

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility

Search

Quick links