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Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination

Chromosome synapsis is an essential process during meiotic recombination and gametogenesis. Here they show that TRIP13-dependent removal of HORMAD1 and HORMAD2 from synapsed chromosome axes during meiotic prophase is crucial for female fertility, as it prevents aberrant chromosome asynapsis checkpoint activation and unintended oocyte elimination.

Xiaofei Jiao
Zhongyang Liang
Lin-Yu Lu
ResearchOpen Access06 Mar 2025
Nature Communications

Volume: 16, P: 1-15
Chemically engineered antibodies for autophagy-based receptor degradation

Cheng et al. developed an autophagy-based targeted protein degradation platform by conjugating polyethylenimine to antibodies, designated as autophagy-inducing antibodies, which can degrade proteins in vivo and enable the degradation of multiple proteins at the same time.

Binghua Cheng
Meiqing Li
Hongchang Li
Research09 Jan 2025
Nature Chemical Biology

Volume: 21, P: 855-866
Author Correction: R-loop-dependent promoter-proximal termination ensures genome stability

Congling Xu
Chengyu Li
Fei Xavier Chen
Amendments and CorrectionsOpen Access20 Jan 2025
Nature

Volume: 638, P: E1
Experimental confirmation of driving pressure boosting and smoothing for hybrid-drive inertial fusion at the 100-kJ laser facility

In laser-driven inertial fusion, finding optimal driving pressure is a major challenge. Here, the authors use a 100 kJ SG laser and a hybrid-drive scheme to demonstrate such driving pressure with the help of the direct-drive laser such that the indirect-drive radiation ablation pressure is turned into a well-smoothed hybrid-drive pressure much greater than the radiation ablation pressure.

Ji Yan
Jiwei Li
Shaoping Zhu
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-9
R-loop-dependent promoter-proximal termination ensures genome stability

SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

Congling Xu
Chengyu Li
Fei Xavier Chen
ResearchOpen Access09 Aug 2023
Nature

Volume: 621, P: 610-619
SST neurons in the periaqueductal gray regulate urination and bladder function

Somatostatin (SST)-positive neurons in the lateral and ventrolateral PAG regulate urination and bladder function via the PAG-PMC pathway, providing new insights into bladder control and potential therapeutic targets for bladder dysfunction.

Junan Yan
Ziyan Gao
Jiwei Yao
ResearchOpen Access21 Apr 2025
Communications Biology

Volume: 8, P: 1-16
Stable and low-photovoltage-loss perovskite solar cells by multifunctional passivation

The use of a dimensionally graded 2D perovskite interface and passivation results in perovskite solar cells with very low photovoltage loss.

Guang Yang
Zhiwei Ren
Gang Li
Research05 Jul 2021
Nature Photonics

Volume: 15, P: 681-689
Ferromagnetic single-atom spin catalyst for boosting water splitting

A versatile hydrothermal approach in an operando acidic environment created ferromagnetic single-atom spin catalysts (SASCs). Ni-based SASC exhibits a giant magnetic field enhancement of OER activity, boosting both water and saline water electrolysis.

Tao Sun
Zhiyuan Tang
Jiong Lu
Research25 May 2023
Nature Nanotechnology

Volume: 18, P: 763-771
A corticopontine circuit for initiation of urination

A small cluster of brainstem-projecting layer 5 neurons in primary motor cortex elicit contraction of the bladder muscle and trigger urination. These findings open new directions for treating urination-related disorders.

Jiwei Yao
Quanchao Zhang
Xiaowei Chen
Research25 Oct 2018
Nature Neuroscience

Volume: 21, P: 1541-1550
Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma

Liangsong Zhu
Yilun Hong
Jin Zhang
ResearchOpen Access19 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-9
Giant energy-storage density with ultrahigh efficiency in lead-free relaxors via high-entropy design

Dielectric ceramics are widely used in advanced high/pulsed power capacitors. Here, the authors propose a high-entropy strategy to design “local polymorphic distortion” in lead-free ceramics, achieving high energy storage performance.

Liang Chen
Shiqing Deng
Jun Chen
ResearchOpen Access02 Jun 2022
Nature Communications

Volume: 13, P: 1-8
Clinical efficacy of enhanced recovery surgery in Da Vinci robot-assisted pancreatoduodenectomy

Zhenxing Liu
Honghong Chen
Jiwei Wang
ResearchOpen Access15 Sept 2024
Scientific Reports

Volume: 14, P: 1-7
Signature of quantum Griffiths singularity state in a layered quasi-one-dimensional superconductor

Whether the quantum Griffiths singularity state exists in one-dimensional (1D) systems remains elusive. Here, Zhang et al. report violation of the Pauli limit in the superconducting critical field and multiple phase transitions in the current-voltage hysteresis loops in a Ta₂PdS₅ nanowire, suggesting signatures of quasi-1D quantum Griffith singularity.

Enze Zhang
Jinhua Zhi
Faxian Xiu
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-9
IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Shengjie Wang
Chao Liu
Jiwei Tian
ResearchOpen Access23 Jun 2017
Scientific Reports

Volume: 7, P: 1-13
A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2

Zeyun Mi
Jiwei Ding
Shan Cen
ResearchOpen Access16 Dec 2015
Scientific Reports

Volume: 5, P: 1-13
Evaluation of Ca₃Co₂O₆ as cathode material for high-performance solid-oxide fuel cell

Tao Wei
Yun-Hui Huang
Zhao-Liang Zhang
ResearchOpen Access24 Jan 2013
Scientific Reports

Volume: 3, P: 1-6
Hypothalamic supramammillary neurons that project to the medial septum modulate wakefulness in mice

In vivo recordings show that a subset of supramammillary neurons that project to the medial septum are wake-active, and projection-specific manipulations reveal that this hypothalamic-septal projection contributes to wakefulness modulation.

Mengru Liang
Tingliang Jian
Han Qin
ResearchOpen Access12 Dec 2023
Communications Biology

Volume: 6, P: 1-13
Carbon and oxygen isotope characteristics of carbonate rocks in the Mesoproterozoic Jixian System of the Ordos Basin and their implications

Liu Xiaofeng
Hong Zenglin
Li Shifeng
ResearchOpen Access28 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo
Xiaobo Lei
Shan Cen
ResearchOpen Access27 Dec 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-12
Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial

Yuxin Zheng
Xuezong Wang
Aiping Lu
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

Erwei Zuo
Yi-Jun Cai
Hui Yang
ResearchOpen Access06 Jun 2017
Cell Research

Volume: 27, P: 933-945

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