Nature Search

AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine

Efficient AAV gene delivery to the heart remains a challenge and hinders clinical translation. Here, coronary Stop-flow delivery with mechanical circulatory support dramatically improved gene expression while securing safety in a swine heart failure model.

Renata Mazurek
Serena Tharakan
Kiyotake Ishikawa
ResearchOpen Access01 Dec 2024
Nature Communications

Volume: 15, P: 1-12
Correction: ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC

Tongjia Zhang
Lizhen Qiu
Kailong Li
Amendments and CorrectionsOpen Access22 May 2025
Cell Death & Disease

Volume: 16, P: 1-5
Generic protein–ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling

Machine learning can improve scoring methods to evaluate protein–ligand interactions, but achieving good generalization is an outstanding challenge. Cao et al. introduce EquiScore, which is based on a graph neural network that integrates physical knowledge and is shown to have robust capabilities when applied to unseen protein targets.

Duanhua Cao
Geng Chen
Mingyue Zheng
Research06 Jun 2024
Nature Machine Intelligence

Volume: 6, P: 688-700
An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy

Ye and colleagues show that an oncolytic virus that delivers tumor-irrelevant bystander T cell epitopes to tumor cells can exploit the abundant population of bystander T cells in the tumor for anti-tumor immunity and potentiate cancer immunotherapy.

Xiangyu Chen
Jing Zhao
Lilin Ye
ResearchOpen Access12 Apr 2024
Nature Cancer

Volume: 5, P: 1063-1081
The transcription factor TCF-1 initiates the differentiation of T_FH cells during acute viral infection

Follicular helper T cells (T_FH cells) require the transcription factor Bcl-6 and are antagonized by the transcription factor Blimp1 (encoded by Prdm1). Lilin Ye and colleagues show that acute viral infection induces the transcription factor TCF-1, which promotes T_FH differentiation by enhancing Bcl6 expression while suppressing that of Prdm1.

Lifan Xu
Yi Cao
Yuzhang Wu
Research27 Jul 2015
Nature Immunology

Volume: 16, P: 991-999
Effect of plant density on yield and Quality of perilla sprouts

Liuliu Wu
Zhe Deng
Li Meng
ResearchOpen Access18 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC

Tongjia Zhang
Lizhen Qiu
Kailong Li
ResearchOpen Access16 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-13
The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection

Xiangyu Chen
Guoshuai Cao
Lilin Ye
ResearchOpen Access06 Mar 2019
Cellular & Molecular Immunology

Volume: 17, P: 247-260
SEPT9_i1 regulates human breast cancer cell motility through cytoskeletal and RhoA/FAK signaling pathway regulation

Yongqiu Zeng
Yang Cao
Yansen Cai
ResearchOpen Access26 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-16

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