Nature Search

Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice

Zhang et al. identify GLP-1 receptor agonists mitigating Alzheimer’s disease-related cognitive decline and amyloid pathology in a transgenic mouse model via promoting phagocytosis and through activation of the CaMKK2–AMPK signaling pathway.

Yun Zhang
Huaqiu Chen
Weihong Song
Research20 May 2025
Nature Aging

Volume: 5, P: 1097-1113
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite

Carbohydrates are essential for regulating various biological processes. Here, the authors developed DeepGlycanSite, a deep learning model that accurately predicts carbohydrate-binding sites on proteins, offering insights into carbohydrate regulation of therapeutically important proteins.

Xinheng He
Lifen Zhao
Xi Cheng
ResearchOpen Access17 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Author Correction: Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat

Chunhao Dong
Lichao Zhang
Xu Liu
Amendments and CorrectionsOpen Access14 Jun 2023
Nature Communications

Volume: 14, P: 1
Blockade of Tim-3 Pathway Ameliorates Interferon-_γ Production from Hepatic CD8⁺ T Cells in a Mouse Model of Hepatitis B Virus Infection

Ying Ju
Nan Hou
Chunhong Ma
Research01 Feb 2009
Cellular & Molecular Immunology

Volume: 6, P: 35-43
Self-adaptive strain-relaxation optimization for high-energy lithium storage material through crumpling of graphene

Crumpled graphene structures are promising for electrochemical energy storage. Here, the authors synthesize deeply crumpled pinecone-like graphene sheets, which show self-adaptive folding-unfolding behaviours in cycling leading to robust battery performances.

Yunlong Zhao
Jiangang Feng
Liqiang Mai
Research01 Aug 2014
Nature Communications

Volume: 5, P: 1-8
Readily releasable β cells with tight Ca²⁺–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion

This study reveals functional heterogeneity at the level of exocytosis among β cells and identifies a subpopulation of β cells that make a disproportionally large contribution to insulin release from mouse islets.

Xiaohong Peng
Huixia Ren
Liangyi Chen
Research26 Jan 2024
Nature Metabolism

Volume: 6, P: 238-253
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury

Mitochondria dysfunction contributes to acute liver injuries. Zhang et al. find that Zhx2 deletion enhances mitochondrial function by promoting electron transport chain gene expression via PGC-1α dependent and independent manner.

Yankun Zhang
Yuchen Fan
Chunhong Ma
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-18
Association between admission serum albumin and 12-weeks mortality in patients with late AIDS/HIV diagnosis: a retrospective cohort study

Rui Huang
Yixian Shi
Ling Chen
ResearchOpen Access09 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Selective N-glycan editing on living cell surfaces to probe glycoconjugate function

Cellular glycosylation facilitates molecular recognition of cells and biomolecules. A two-step N-glycan editing method enables selective glycoform ‘deletion’ and ‘insertion’ of new glycans, which can be used to probe their biological functions.

Feng Tang
Mang Zhou
Wei Huang
Research01 Jun 2020
Nature Chemical Biology

Volume: 16, P: 766-775
Disorder-tuned conductivity in amorphous monolayer carbon

Varying growth temperatures enables the tuning of the degree of disorder, which is fully described by the absence/presence of medium-range order and temperature-dependent densities of nanocrystallites, and electrical conductivity in amorphous monolayer carbon films.

Huifeng Tian
Yinhang Ma
Lei Liu
Research01 Mar 2023
Nature

Volume: 615, P: 56-61
Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat

Tiller number is an important agronomic trait of wheat. Here, the authors clone a positive regulator of wheat tiller number and show that the encoded ankyrin repeat protein can promote tiller bud outgrowth through inhibiting ABA biosynthesis and signaling.

Chunhao Dong
Lichao Zhang
Xu Liu
ResearchOpen Access14 Feb 2023
Nature Communications

Volume: 14, P: 1-13
IMU-Based quantitative assessment of stroke from gait

Yiou Sun
Zhenhua Song
Dong Wang
ResearchOpen Access19 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Neural mechanisms for selectively tuning in to the target speaker in a naturalistic noisy situation

When many people are speaking, e.g. at a party, we can selectively attend to just one speaker. Here, using ‘hyperscanning’, the authors show that interpersonal neural synchronization is selectively increased between a listener and the attended speaker, compared to between the listener and an unattended speaker.

Bohan Dai
Chuansheng Chen
Chunming Lu
ResearchOpen Access19 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Complete Genome Characterization of a Novel Enterovirus Type EV-B106 Isolated in China, 2012

Jingjing Tang
Zexin Tao
Wenbo Xu
ResearchOpen Access03 Mar 2014
Scientific Reports

Volume: 4, P: 1-7
HER2-targeting CAR-T cells show highly efficient anti-tumor activity against glioblastoma both in vitro and in vivo

Xueying Li
Lifen Zhao
Nianzhu Zhang
ResearchOpen Access03 May 2024
Genes & Immunity

Volume: 25, P: 201-208
Correction: TRPC6-dependent Ca²⁺ signaling mediates airway inflammation in response to oxidative stress via ERK pathway

Qingzi Chen
Yubo Zhou
Jianhua Li
Amendments and CorrectionsOpen Access25 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-2
Variations in triple oxygen isotope of speleothems from the Asian monsoon region reveal moisture sources over the past 300 years

Variations in the moisture source drove regional circulation in the Asian monsoon region during the past 300 years, suggests an analysis of the triple oxygen isotope data in speleothems

Lijuan Sha
Jasper A. Wassenburg
Hai Cheng
ResearchOpen Access18 Oct 2023
Communications Earth & Environment

Volume: 4, P: 1-10
TRPC6-dependent Ca²⁺ signaling mediates airway inflammation in response to oxidative stress via ERK pathway

Qingzi Chen
Yubo Zhou
Jianhua Li
ResearchOpen Access05 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-16
Isothermal crystallization of poly(L-lactide) and poly(butylene adipate) crystalline/crystalline blends

Isothermal crystallization of PLLA/PBA blends shows great difference to that of neat polymer. Blends have faster crystallization rate and lower melting temperature than PLLA in high-temperature region. However, blends form different crystal structures to that of neat PBA at low temperatures and have lower crystallization rate. The crystallization rate, morphology and crystal structure of neat PLLA and PBA can be modulated by mutual blending.

Lifen Zhao
Junjun Kong
Shengxue Qin
Research19 Mar 2014
Polymer Journal

Volume: 46, P: 323-329
Tim-4 protects mice against lipopolysaccharide-induced endotoxic shock by suppressing the NF-κB signaling pathway

Liyun Xu
Peiqing Zhao
Lifen Gao
Research12 Sept 2016
Laboratory Investigation

Volume: 96, P: 1189-1197
Miscibility and morphology of binary crystalline blends of poly(L-lactide) and poly(butylene adipate)

The morphology of PLLA/PBA crystalline/crystalline system reveals abundant morphologies in different crystallization condition. Neat PLLA and PBA usually show Maltese-cross spherulites. However, banded spherulites and branched structures of blends formed in high-temperature region in this work. In addition, fragments morphology is discovered in low-temperature region. These different morphologies are related to the changes of crystallization environment caused by crystalline/crystalline blending.

Lifen Zhao
Xinyu Peng
Jun Zhang
Research06 Mar 2013
Polymer Journal

Volume: 45, P: 929-937
Increased expression of human T-cell immunoglobulin- and mucin-___domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus

Peiqing Zhao
Liyun Xu
Lifen Gao
Research08 Feb 2010
Cellular & Molecular Immunology

Volume: 7, P: 152-156
Retraction Note: Functional screen analysis reveals miR-3142 as central regulator in chemoresistance and proliferation through activation of the PTEN-AKT pathway in CML

Lifen Zhao
Yujia Shan
Li Jia
Amendments and CorrectionsOpen Access12 Feb 2020
Cell Death & Disease

Volume: 11, P: 1
Transcriptional insights into the pyramided resistance to rice bacterial blight

Lifen Gao
Zhiwei Fang
Hai Peng
ResearchOpen Access17 Aug 2018
Scientific Reports

Volume: 8, P: 1-11
Peptide targeting the interaction of S protein cysteine-rich ___domain with Ezrin restricts pan-coronavirus infection

Zhuanchang Wu
Xiaobo Lei
Chunhong Ma
ResearchOpen Access18 Jan 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-4
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response

Siyu Tan
Zehua Wang
Chunhong Ma
Research15 Aug 2023
Cell Death & Differentiation

Volume: 30, P: 2104-2119
Variations in seismic parameters for the earthquakes during loading and unloading periods in the Three Gorges Reservoir area

Lifen Zhang
Wulin Liao
Ziyan Zhou
ResearchOpen Access02 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson’s disease

Yuke Zhong
Hang Liu
Lifen Chen
ReviewsOpen Access24 Jun 2022
npj Parkinson's Disease

Volume: 8, P: 1-9
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes

Liyuan Wang
Yang Sun
Chunhong Ma
Research12 Jul 2021
Cellular & Molecular Immunology

Volume: 18, P: 1871-1882
Molecular Epidemiology and Recombination of Human Enteroviruses from AFP surveillance in Yunnan, China from 2006 to 2010

Jingjing Tang
Hiromu Yoshida
Lifen Zhang
ResearchOpen Access14 Aug 2014
Scientific Reports

Volume: 4, P: 1-8
MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway

Yuan Miao
Wei Zheng
Li Jia
ResearchOpen Access06 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner

Qianqian Zhang
Hongxing Wang
Lifen Gao
ResearchOpen Access29 Oct 2015
British Journal of Cancer

Volume: 113, P: 1484-1492
Ribosomal protein S26 serves as a checkpoint of T-cell survival and homeostasis in a p53-dependent manner

Chaojia Chen
Jiali Peng
Chunhong Ma
Correspondence25 May 2021
Cellular & Molecular Immunology

Volume: 18, P: 1844-1846
Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4

Xiaolu Ma
Weijie Dong
Li Jia
ResearchOpen Access29 Dec 2016
Cell Death & Disease

Volume: 7, P: e2561
RETRACTED ARTICLE: Functional screen analysis reveals miR-3142 as central regulator in chemoresistance and proliferation through activation of the PTEN-AKT pathway in CML

Lifen Zhao
Yujia Shan
Li Jia
ResearchOpen Access25 May 2017
Cell Death & Disease

Volume: 8, P: e2830
MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer

Nana Li
Yuan Miao
Li Jia
ResearchOpen Access18 May 2017
Cell Death & Disease

Volume: 8, P: e2796
MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5

Hongjiao Cai
Huimin Zhou
Li Jia
Research20 Feb 2017
Laboratory Investigation

Volume: 97, P: 530-542
Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1

Yan Li
Shihua Luo
Li Jia
Research18 Apr 2016
Laboratory Investigation

Volume: 96, P: 731-740
Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer

Yang Li
Zheng Sun
Li Jia
ResearchOpen Access22 Jun 2017
Cell Death & Disease

Volume: 8, P: e2892

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