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The stem cells in the Arabidopsis root meristem are maintained by the expression of the transcription factor WOX5 in the stem cell organizer. This study reveals that WOX5 functions in a coherent feed-forward loop, regulating auxin signalling.

Understanding the dynamic evolution of heterogeneous catalysts is crucial yet challenging. This work uncovers the transformation of amorphous PtIn clusters into ultrafine Pt₃In intermetallics, driven by propylene during propane dehydrogenation, highlighting the pivotal role of product-induced changes in revealing the true active sites.

This study shows GS2 controls seed size by activating SUG1 expression, which encodes a transcriptional regulator that interacts with multiple TFs to control seed growth via GA and BR pathways. SUG1⁹³¹¹ allele offers the potential to improve rice yield.

The authors perform a genome-wide association study of adolescent idiopathic scoliosis patients of Han Chinese descent, and identify 3 new loci for disease susceptibility.

The east-west admixture profile in eastern China of Tang Dynasty inferred from ancient human genomes suggested that the intermarriage with Han Chinese involved the Sinicization process of the Hu people.

Evidence for comprehensive assessment of cardiovascular disease (CVD) burden attributable to high fasting plasma glucose (FPG) in China is limited. Here, the authors show CVD deaths attributable to high FPG varied substantially across China. Exposure to high FPG and population aging were the primary drivers of increased CVD burden.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

Though broadband achromatic metalens are attractive for biological applications, existing metalenses show limited performance in the biological imaging window. Here, the authors report high-efficiency broadband achromatic metalens featuring record-high aspect ratio titanium dioxide metasurfaces.

Poly-ethylene terephthalate (PET) is a widely used plastic which accumulates in the environment with detrimental consequences. Here the authors report crystal structures of a PET-hydrolyzing enzyme from the microbe Ideonella sakaiensis bound to substrate and product analogs, and suggest a catalytic mechanism for its PET-degrading activity.

Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al.perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability.

Accurate mapping of strain distribution calls for strain sensor arrays with high sensitivity, high sensing density and inter-unit consistency. Here, the authors report an array made from ordered assembly of monodispersed spiky carbon nanospheres to achieve the above features simultaneously.

Nitrogen oxides are vital in the nitrogen cycle and renewable chemical synthesis, but selective conversion to multi-nitrogen products via precise N-N bond formation is challenging. Here, the authors report a two-step electrochemical process that achieves an impressive 88.7% selectivity for hydrazine production using a WO₃ catalyst with diphenyl ketone as a mediator.

Hantaan virus is carried and transmitted by rodents and results in asymptomatic infection, yet transmission to humans’ results in symptomatic disease and development of hemorrhagic fever with renal syndrome. Here the authors explore the disparate effects in myeloid cells from mice and humans.

High-throughput proteome-wide methods for identifying endogenous proteins that phase separate or partition into condensates during certain physiological events are needed but remain a challenge. Now, a high-throughput, unbiased and quantitative strategy can identify endogenous biomolecular condensates and screen proteins involved in phase separation on a proteome-wide scale.

The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern and early assessment would be vital. Here, the authors show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical characteristics at admission.

Efficient electroreduction of CO2 to multi-carbon products under strong acidic condition is highly challenging. Here, the authors demonstrate that combining microenvironment modulation and La doping effect could promote multicarbon products generation in acidic electrolyte.

The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ₄₂, humanin, or formyl peptides offer insight into Aβ₄₂ neurotoxicity, humanin neuroprotection, and FPR ligand selectivity

Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmice.

Structures of the glucagon receptor bound to β-arrestin 1 are reported, providing further information about the arrestin-mediated modulation of G protein-coupled receptors.

A dual-site catalyst consisting of Cu nanoparticles (NPs) and atomic Cu sites is designed. The atomic Cu boosts H2O dissociation for modulating the *H coverage on Cu NPs, improving the efficiency of CO2 electroreduction to multi-carbon products.

The human neuropeptide Y receptor Y₂ (Y₂R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y₂R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity of NPY receptors.

Formyl peptide receptors (FPRs) are GPCRs that play important roles in transducing chemotactic signals in phagocytes and mediating host-defense and inflammatory responses. Here the authors present the 2.8 Å crystal structure of human FPR2 in complex with the peptide agonist WKYMVm and in combination with molecular docking, ligand-binding and signalling assays provide further insights into the binding modes of FPR2 to both non-formyl and formyl peptides.

Fullerenes are promising organic semiconducting materials for electronic applications, but of low conductivity due to limited intermolecular hybridization. Cui et al. show a black phosphorous substrate organizes C₆₀ monolayers to form delocalized semiconducting band with tens times enhanced conductivity.

The crystal structure of the full-length human glucagon receptor reveals the essential role of the 12-residue ‘stalk’ segment and an extracellular loop in the regulation of ligand binding and receptor activation.

Cryo-electron microscopy structures of the adhesion G protein-coupled receptors ADGRD1 and ADGRF1 provide insight into how these receptors are activated in an intrinsic manner through a ‘stalk’ region that acts as a tethered agonist.

Two X-ray crystal structures are presented of the human P2Y₁ G-protein-coupled receptor, which is an important target for anti-thrombotic drugs; the structures unexpectedly reveal two ligand-binding sites.

Visceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, PRDM16.