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Nellie is a comprehensive automated pipeline for studying the structure and intracellular dynamics of diverse organelles that offers accurate segmentation, tracking and feature extraction on both 2D and 3D data.

Controlling selectivity between H₂O splitting and CO₂ reduction remains challenging in artificial photosynthesis. Here, the authors report light-driven conversion of Fe to FeCo bimetallic sites in nitroprusside, switching catalytic selectivity from H₂ evolution to CO₂ reduction.

Asia’s biotech opportunities attract brains to the region.

Using a tuning fork-based probe, the authors offer evidence of 2D magnetic moment along the c-axis of CsV₃Sb₅. Their findings suggest that loop currents within the kagome lattice can generate orbital magnetism.

Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

High-performance THz electromagnetic shielding is demonstrated using 2D β₁₂-borophene nanosheets embedded in a polymer matrix. At a low loading of 0.1 wt.%, the composite has excellent shielding effectiveness and good mechanical properties.

Li et al. report free-standing layered polymer–perovskite composite membranes that reconcile mechanical flexibility with electronic properties. They endure 30,000 bends at a 1.5 mm radius, enabling wearable radiation monitoring in complex conditions.

CYSLTR2 and P2RY6 are identified as endogenous ceramide receptors, and inhibition of these ameliorates atherosclerosis, particularly in chronic-kidney-disease-associated cardiovascular disease.

Prussian blue analogues are promising for aqueous batteries but interstitial water effects remain underexplored. Here, authors develop a cation-self-shielding strategy with dihydroxyacetone to stabilize water-rich Prussian blue analogues for application in K-ion batteries.

A small-molecule agonist of transient receptor potential cation channel subfamily M member 4 persistently activates the ion channel and induces necrosis characterized by sodium overload.

The electrosolvation force drives a counterintuitive attraction between particles with the same *SIGN OF* electrical charge in solution. Here the authors show that the force can be modulated by molecular species that are known to alter the interfacial water structure.

The authors develop an optical gearbox to accelerate the laser scanning microscopes, achieving flexible adjustment of imaging frame rate from tens of Hz to 1 kHz. The technology is validated through in vivo functional imaging of mice brains.

How animals learn that reward is predicted by multi-event sequences consisting of sensory stimuli and actions remains poorly understood. Here, the authors show that such learning starts from the event closest to the reward and sequentially incorporates earlier events.

The mechanisms underlying circadian homeostasis remain elusive. Here, the authors show that anti-Müllerian hormone (Amh)-mediated signaling sustains molecular clock oscillations in the pituitary gland, thereby maintaining circadian homeostasis at both tissue and systemic levels.

CAR T cell manufacturing faces significant challenges that impact cell quality and in vivo efficacy. This necessitates reliable cellular characterization methods. Here the authors present a real-time, label-free, microfluidic method that profiles cellular biophysical properties and correlates them to activation state and CAR T potency, facilitating the rapid phenotypic cell assessment during production.

Using microseismic noise observed by distributed acoustic sensing (DAS) with a submarine cable, this study measures the magnitude and direction of ocean currents during the passage of typhoon Muifa and estimates the ocean wave propagation.

A pan-genome of S. frugiperda suggests that LTR alterations could be a driving factor for genome size variation. Genes are enriched in functions which might be associated in detoxification, implying detoxification selection pressure.

Helicobacter pylori (H. pylori) establishes chronic infection in human, but the underlying mechanistic insights are lacking. Here the authors use single cell RNA and TCR sequencing to profile peripheral blood and mucosal cells from infected patients to report alterations in macrophage differentiation and T cell gene signature that may contribute to persisting H. pylori infection.

Zhang et al. present a sequential electrochemical process that enables synergetic physical damage and chemical oxidation of antibiotic-resistant bacteria and antibiotic resistance genes, providing an efficient and residue-free water disinfection approach.

Knowing one’s own behavioral state is important to contextualize sensory cues and identify appropriate future actions. Here the authors show how neurons ascending from the fly motor system convey behavioral state signals to specific brain regions.

The delta opioid receptor (δOR) is key in modulating sensation and emotion with a lower risk of drug dependence. Here, authors report cryo-EM structure of δOR and design probes to explore its signaling bias, with insights for drug discovery.

Yin et al. harmonized 1,091 fMRI scans across five imaging cohorts to map developmental trajectories of brain functional connectivity in early childhood, revealing early brain development and its links to cognitive abilities.

CRISPRme is an off-target nomination tool that accounts for human genetic diversity. Ancestry-dependent allele-specific off-target edits can occur with therapies currently in clinical trials, highlighting the importance of genetic variation-aware assessment.

FADD binds Casp-8 and then cFLIP to form the FADD-Casp8-cFLIP complex. The authors found that the DED complex could assemble in reverse order, where cFLIP oligomerizes to bind Casp-8. The resultant complex could bind FADD, generating the cFLIP-Casp-8-FADD complex by a different mechanism.

Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.

In this work, authors show that randomized water, sanitation, hygiene and nutrition interventions reduced child antibiotic use in Bangladesh (in parallel with high intervention uptake and reduced infections) but not Kenya (in parallel with lower uptake and no effect on infections).

Pathological retinal neovascularization (RNV) is a major cause of blindness. Here, the authors show that endothelial protein C receptor (EPCR) promotes RNV through carbon monoxide derived from heme catabolism, and blocking EPCR offers therapeutic potential for the treating RNV.

Here, Tulsian et al. identified the effect of biologically relevant full-length IgG binding on the Spike protein from different SARS-CoV-2 variants to comprehensively understand the mechanisms of antibody evasion, towards the development of better antiviral strategies.

Facemap is a data analysis framework for tracking keypoints on mouse faces and relating them to large-scale neural activity. Both of these steps use state-of-the-art convolutional neural networks to achieve high precision and fast processing speeds.

A study reports that the structural maturation of the matrix ___domain of the Gag protein of HIV-1 is induced by the proteolytic release and binding of the spacer peptide SP2.

ezSingleCell is an interactive and user-friendly application for the analysis of single-cell and spatial omics data, without the need for programming expertise. Here, authors integrated top-performing publicly available methods to enable comprehensive data analysis and interactive visualisation.

A critical step to enable practical structural superlubricity (SSL) applications is to enable high throughput to both fabrication and performance evaluation. Here, the authors demonstrate an automated system for efficient and multiple SSL materials transfer and tribological measurement.

Although continuous monitoring of tissue oxygenation is critically important after tissue/organ graft procedures, current technologies have key limitations. Here, the authors develop a miniaturized, minimally invasive, self-anchoring optical probe and demonstrate continuous monitoring of oxygenation in porcine flap and organ models.

Fluorescent proteins can report on many cellular variables. Here, authors develop a method for reporting high local densities, and use it to show that density distribution of heterochromatin in mouse embryonic stem cells are not in a liquid phase.

Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

Agonists selectively targeting GPR119 hold promise for treating metabolic disorders. Here, authors reveal that GPR119 adopts a non-canonical consensus structural scaffold with an extended ligand-binding pocket for chemically different agonists.

Cervical screening is a key method for detecting cervical cancer, but is limited by pathologist detection. Here, the authors use artificial intelligence to predict cytology grades from whole slide images.

Cryo-electron microscopy and molecular dynamics simulations reveal how MFSD2A transports essential omega-3 fatty acids across the blood–brain and blood–retina barriers as lysolipids.

The crystallographic and cryo-EM structures of CB1 bound to the positive allosteric modulator ZCZ011, combined with molecular dynamics simulations and mutagenesis experiments, reveal allosteric modulation of CB1 by rearrangement of the TM2 and TM3 transmembrane domains.

How dynamic transcription factors temporally interact to regulate stress survival in yeast is currently unclear. Here the authors integrate single-cell imaging, RNA-seq, and modeling to identify a new cell fate control mechanism mediated by temporal redundancy modulation during yeast stress response.

MCMICRO is a modular and open-source computational pipeline for transforming highly multiplexed whole-slide images of tissues into single-cell data. MCMICRO is versatile and can be used with CODEX, mxIF, CyCIF, mIHC and H&E staining data.