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Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

The role of Leflunomide in αPD1-induced cardiotoxicity remains unclear. Here, the authors show that leflunomide mitigates αPD1-induced cardiac toxicity in melanoma-bearing mice through modulation of the microbiota-indole-3-propionic acid-heart axis.

Rong Huang
Zhuo-Yu Shen
Zhen-Guo Ma
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-15

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Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

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