Nature Search

Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA

Chen, Zhou, Xue et al. show that psychological stress leads to noradrenaline release and Alkbh5 downregulation, causing the transfer of extracellular vesicles containing m⁶A-modified RNAs to neurons to regulate innervation and pancreatic cancer development.

Ziming Chen
Yifan Zhou
Jian Zheng
Research26 May 2025
Nature Cell Biology

Volume: 27, P: 1035-1047
Super-enhancer RNA m⁶A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma

In pancreatic duct adenocarcinoma, super-enhancer RNAs (seRNAs) have higher N⁶-methyladenosine (m⁶A) levels than in adjacent normal tissue due to upregulation of the METTL3 cofactor CFL1. Aberrant m⁶A seRNAs promote oncogene expression via the YTHDC2–MLL1 complex.

Rui Li
Hongzhe Zhao
Jian Zheng
Research13 Nov 2023
Nature Genetics

Volume: 55, P: 2224-2234
CSTF2 mediated mRNA N⁶-methyladenosine modification drives pancreatic ductal adenocarcinoma m⁶A subtypes

N6-methyladenosine (m6A) modification has important implications in different cancer subtypes. Here, the authors perform transcriptomic m6A profiling to identify two subtypes of pancreatic ductal adenocarcinoma with differential m6A modifications and different clinical outcomes, which is driven by m6A regulator CSTF2.

Yanfen Zheng
Xingyang Li
Zhixiang Zuo
ResearchOpen Access10 Oct 2023
Nature Communications

Volume: 14, P: 1-17
RNA m⁶A regulates transcription via DNA demethylation and chromatin accessibility

METTL3-dependent RNA N⁶-methyladenosine (m⁶A) deposition can lead to DNA demethylation. The m⁶A reader FXR1 recruits DNA 5-methylcytosine dioxygenase TET1 to chromatin, which is linked to chromatin accessibility and gene transcription.

Shuang Deng
Jialiang Zhang
Jian Zheng
Research07 Sept 2022
Nature Genetics

Volume: 54, P: 1427-1437
LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling

The implications of long intergenic non-coding RNAs (lincRNAs) on cancer metabolism is unclear. Here, the authors identify that LINC00842 binds to PGC-1α and prevents PGC-1α from deacetylation by SIRT1, resulting in a metabolic reprogramming in pancreatic cancer cells.

Xudong Huang
Ling Pan
Jian Zheng
ResearchOpen Access22 Jun 2021
Nature Communications

Volume: 12, P: 1-16
CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer

Xiaowei He
Ji Liu
Jialiang Zhang
Research19 Feb 2025
Cell Death & Differentiation

Volume: 32, P: 973-988
LncRNA BCAN-AS1 stabilizes c-Myc via N⁶-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer

Guandi Wu
Jiachun Su
Jian Zheng
Research19 Sept 2023
Cell Death & Differentiation

Volume: 30, P: 2213-2230
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization

Jiachun Su
Guandi Wu
Jian Zheng
ResearchOpen Access03 Aug 2021
Oncogene

Volume: 40, P: 5814-5828

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Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA

Super-enhancer RNA m⁶A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma

CSTF2 mediated mRNA N⁶-methyladenosine modification drives pancreatic ductal adenocarcinoma m⁶A subtypes

RNA m⁶A regulates transcription via DNA demethylation and chromatin accessibility

LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling

CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer

LncRNA BCAN-AS1 stabilizes c-Myc via N⁶-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer

NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization

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