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Showing 1–3 of 3 results
Advanced filters: Author: Linsey Reavie Clear advanced filters

  • T-cell acute lymphoblastic leukaemia (T-ALL) patients are at an increased risk of central nervous system (CNS) relapse, and yet, despite its clinical importance, little is known about the mechanism of leukaemic cell infiltration of the CNS. Here, using T-ALL animal modelling and gene-expression profiling, the chemokine receptor CCR7 is shown to be the essential adhesion signal required for the targeting of leukaemic T cells into the CNS.

    • Silvia Buonamici
    • Thomas Trimarchi
    • Iannis Aifantis
    Research
    Nature
    Volume: 459, P: 1000-1004

  • PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were unclear; here, using a genetic approach in mice, the PIK3CAH1047R mutation is shown to induce multipotent stem-like cells and mammary tumours with different levels of malignancy depending on the cell of origin.

    • Shany Koren
    • Linsey Reavie
    • Mohamed Bentires-Alj
    Research
    Nature
    Volume: 525, P: 114-118