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Showing 1–2 of 2 results
Advanced filters: Author: Lisa Newhook Clear advanced filters
  • The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cytotoxicity, signal inhibition, antibody dependent cellular cytotoxicity and phagocytosis.

    • Nina E. Weisser
    • Mario Sanches
    • Surjit Dixit
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22
  • Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when compared with current CARs.

    • Christopher W. Helsen
    • Joanne A. Hammill
    • Jonathan L. Bramson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13