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Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors

Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling within 24 hours.

Areeba Patel
Kirsten Göbel
Felix Sahm
ResearchOpen Access25 Mar 2025
Nature Medicine

Volume: 31, P: 1567-1577
Production of human clotting Factor IX without toxicity in mice after vascular delivery of a lentiviral vector

Lisa V. Tsui
Michael Kelly
James G. McArthur
Research01 Jan 2002
Nature Biotechnology

Volume: 20, P: 53-57
Label-free detection and profiling of individual solution-phase molecules

Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.

Lisa-Maria Needham
Carlos Saavedra
Randall H. Goldsmith
Research08 May 2024
Nature

Volume: 629, P: 1062-1068
Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers

Lisa A Simms
Tong-Tong Zou
Barbara A Leggett
Research29 May 1997
Oncogene

Volume: 14, P: 2613-2618
Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Pilar Mendoza
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature

Volume: 561, P: 479-484
Ganglioside SSEA-4 in Ewing sarcoma marks a tumor cell population with aggressive features and is a potential cell-surface immune target

Silke Jamitzky
Bianca Altvater
Sareetha Kailayangiri
ResearchOpen Access24 May 2024
Scientific Reports

Volume: 14, P: 1-14
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.

Yotam Bar-On
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature Medicine

Volume: 24, P: 1701-1707
Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer

A genome-wide CRISPR/Cas9 screen in osimertinib-treated EGFR mutant cell lines identifies the Hippo pathway as an important non-genetic mechanism of cell survival in persister cells.

Matthias Pfeifer
Jonathan S. Brammeld
Ultan McDermott
ResearchOpen Access24 Apr 2024
Communications Biology

Volume: 7, P: 1-16
Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver

T. Hang Nghiem-Rao
Courtney Pfeifer
Sridhar Rao
ResearchOpen Access11 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells

Steven W. Criscione
Matthew J. Martin
Paul D. Smith
ResearchOpen Access27 Dec 2022
npj Precision Oncology

Volume: 6, P: 1-13