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TERT was dephosphorylated by the protein phosphatase activity of the gluconeogenic enzyme FBP1, leading to inhibition of TERT nuclear translocation and telomere function. Lipid nanoparticle-delivered FBP1 mRNA blunts tumor growth in mice.

Recently, signatures of quantum spin liquid have been reported in monolayer transition metal dichalcogenides. Here the authors report evidence of such state in 1T-NbSe₂ via the measurements of the Kondo effect in a 1T-1H heterostructure, further supported by measurements for magnetic molecules on 1T-NbSe₂.

Fu, Sun, Xue, Zhou et al. show that the mitoprotease LONP1 selectively degrades a complex II component to control intracellular succinate levels, which is needed for white-to-beige adipocyte cell fate programming during adipocyte thermogenic remodelling.

Setaria pan-genome constructed using genome assemblies of 110 representative accessions and variation analyses provides insights into foxtail millet domestication and the genetic basis for crop improvement.

The crystal structure of the complex formed by the death domains from Fas and FADD at physiological pH is now solved, revealing a 5:5 complex that is supported by electron microscopy data. Along with mutagenesis and mass spectrometry analyses, the work provide insight into Fas mutations that cause autoimmune lymphoproliferative syndrome.

In this work, the authors discovered that Panax species, the valuable medicinal plants, have evolved a two-component chemical defence system comprising a chloroplast-localized β-glucosidase and 20(S)-protopanaxadiol ginsenosides.

Shao et al. show that EGFR signaling increases expression of the complement regulatory proteins CD55 and CD59, suppressing the complement. This is mediated via a sponging lncRNA and interfering with the axis synergizes with immunotherapy.

High-performance mechanical metamaterials have been designed through a multilayer strategy and topology optimization, showing capability in approaching the theoretical stiffness limit, as well as prospects in treating multiphysics problems

Realistic quantum mechanical simulations are computationally costly to perform but can be approximated using neural network models. Li and colleagues propose a forward propagation method in lieu of traditional backpropagation to speed up these neural network-based approaches.

Mitochondrial function is important for muscle maintenance and function, and mitochondrial proteolysis maintains mitochondrial integrity and function. Here the authors report that that loss of LONP1-dependent mitochondrial proteolysis in muscle causes reduced muscle mass and strength via activation of autophagy.

Anaerobic bacteria represent a rich source of biological and chemical diversity but are difficult to cultivate and there is a lack of heterologous expression systems. Here the authors develop an expression system based on S. mutans UA159 for biosynthetic gene clusters from anaerobic bacteria.

Low temperature operation of anode-free batteries is limited by poor reversibility of metal plating/stripping. Here, via electrolyte engineering, authors enable −40 °C operation of an anode-free K metal battery by tailoring a weakly solvating electrolyte with a silicone polymer additive.

Influenza continues to represent a major threat to public health, and the development of monoclonal antibodies (mAbs) that provide broad protection remains a key avenue for therapeutic development. Here, the authors demonstrate the molecular basis of neutralization for a human bnAb (PN-SIA28) against both endemic influenza A and emerging pathogens such as bat H17 and H18 viruses.

Here, the authors report a study exploring surface lattice-confined single-atom ruthenium sites which demonstrate remarkable stability and exceptional catalytic performance for auto-exhaust purification, making them a promising alternative to costly Pt/Pd-based catalysts.

Functional revascularization is vital to the recovery of blood flow. Here, Sun et al. show that myofiber FNIP1 is a negative regulator of muscle functional angiogenesis and revascularization after ischemia by controlling macrophage recruitment.

Current single-cell tools are limited by the number of proteins they can analyse. Here the authors report a single-cell cyclic multiplex in situ tagging (CycMIST) method for functional proteome profiling of single cells, allowing multiple rounds of multiplexing of the same single cells on a microchip.

The bandgaps of bilayers of two-dimensional C₃N can be modulated by controlling the stacking order of the layers or by applying an electric field.

The properties of mesoporous nanomaterials have been exploited for several applications, including drug delivery and NIR-II photoacoustic imaging. Here, the authors design monodispersed semimetallic mesoporous antimony nanospheres with photothermal conversion efficiency in the second near-infrared range and drug loading capacity, showing their potential for cancer photothermal/chemo therapy.

The simultaneous identification of position and configuration of double bonds in unsaturated lipids is challenging. Here, the authors develop a workflow for deep structural lipidomics to address this issue using a bifunctional reaction system combined with liquid chromatography-mass spectrometry, revealing double bond patterns in bacteria and in mouse brain ischemia.

Wing touching induces a defensive response in D. melanogaster. Here, the authors show that female flies change the defensive response during courtship and after mating. This switch is mediated by functional reconfiguration of a neural circuit in the ventral nerve cord.

Previous design strategies for pH sensitive aptamers were not readily tunable across pH ranges. Here the authors present a general method to convert aptamers into pH-responsive switches using two orthogonal motifs.

Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.

Broadband spectral photoresponse has potential for optoelectronic devices, but obtaining high photoactivity beyond the material bandgap is challenging. Here, the authors report the development of a molecular pyroelectric material with broadband photopyroelectric effects.

The early detection and accurate histopathological diagnosis of gastric cancer are essential factors that can help increase the chances of successful treatment. Here, the authors report on a digital pathology tool achieving high performance on a real world test dataset and show that the system can aid pathologists in improving diagnostic accuracy.

HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers.

Lin et al. show that MCM8 protects vascular health by mediating nitric-oxide-dependent mitophagy. The common East-Asian MCM8-P276 variant is ineffective in mitophagy, which potentiates cGAS-STING and type I interferon signaling in a mouse model of Kawasaki disease.

A nucleic acid immunoassay implemented on a lateral flow strip accurately detects SARS-CoV-2 RNA in less than one hour via a fluorescence readout.

Morphology control of bulk heterojunction organic solar cells has been a challenge for realising optimal photovoltaic performance. Here, the authors utilise amphiphobic nature and temperature-dependent miscibility of fluorous solvent to promote molecular reorganisation and morphological optimisation.

Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages in mouse models.

Solid polymer electrolytes are commonly used in lithium-metal batteries, but their capacity and energy density cannot be easily increased beyond a charging cut-off voltage of 4.5 V due to the presence of easily oxidized oxygen-bearing polar groups. Here, authors apply a polyfluorinated crosslinker to enhance the oxidation resistance to solve this issue

Li et al. show that the c-Myc-dependent splicing switch from ketohexokinase-C (KHK-C) to KHK-A activates phosphoribosyl pyrophosphate synthetase 1 (PRPS1), resulting in enhanced de novo nucleic acid synthesis and hepatocellular carcinoma formation.

An effective expansion system for therapeutic megakaryocyte-biased hematopoietic stem cells has not been developed. Here the authors present a microniche-based system that supports scalable expansion of human Mk-biased HSCs and identify their immune phenotype.

The diamondback moth, Plutella xylostella is a cosmopolitan agricultural pest. By analyzing 532 genomes from 114 populations around the world, the authors find evidence supporting a South American origin of this moth, and look for signatures of positive selection.

N6-methyladenosine (m⁶A) is one of the most prevalent mRNA modifications in eukaryotes. Here the authors show that the m⁶A writer protein methyltransferase-like (METTL) 3 plays an important role for the development of brown adipose tissue.

A series of materials containing Mo-S clusters confined in zeolitic cages of ZSM-5 are reported and shown to be efficient for CO₂ or CO hydrogenation with >98% selectivity to methanol, stable over 1000 h, or C₂ and C₃ hydrocarbons, stable over 100 h.

Wu et al. show that, upon activation by insulin-like growth factor 1 receptor and AKT, creatine kinase B exhibits a moonlighting function as protein kinase to phosphorylate glutathione peroxidase 4 to prevent its degradation, thereby suppressing ferroptosis and enhancing tumour growth in mice.

The energy band alignment of solar cell materials is highly relevant to the device performance, but its measurement is challenging. Here, the authors report direct visualization of energy band alignment in operating organic photovoltaic devices using scanning Kelvin probe microscopy imaging.

Charged surface defects are expected to undermine the charge extraction in organic-inorganic perovskite solar cells. Here Zhang et al. design ionic fullerene derivatives to not only passivate the charged defects, but also optimize the interfacial energy due to aligned orientation of the fullerenes.

Antiferroelectric (AFE) materials are emerging as a remarkable candidate for efficient energy-storage applications. Here, the authors report on a high-temperature, lead-free, AFE perovskite, (CHMA)₂CsAgBiBr₇ (where CHMA is cyclohexylmethylammonium) with high fatigue endurance at a high electric breakdown field strength.

DNA-binding phage-assisted continuous evolution improves the specificity of DNA-binding proteins, as demonstrated with TALENs.

Liu et al. demonstrate that CK2 phosphorylates CLOCK to promote its nuclear exportation and cytosolic accumulation, thereby acetylating and stabilizing PRPS1/2 and enhancing de novo nucleotide synthesis to facilitate liver tumour growth.

Designing atomically uniform ensemble sites for matching targeted reaction pathway is important yet challenging in heterogeneous catalysis. Here, the authors fabricate a trimer Ni₁Sb₂ site featuring superior selectivity for acetylene semi-hydrogenation via a mechanism-driven design strategy.

Xi and colleagues show that BMP signaling has tumor-suppressive effects in ACVR1 wild-type diffuse intrinsic pontine glioma by modulating stemness via chromatin regulation of CXXC5, and demonstrate the therapeutic potential of this pathway using in vivo mouse models.

Mechanisms that underlie the progression of non-alcoholic fatty liver disease to the more severe non-alcoholic steatohepatitis are incompletely understood. Here the authors show that METTL3, a RNA methyltransferase that catalyzes mRNA m6 modifications, negatively regulates NASH progression via inhibiting the transcription of Cd36 and Ccl2.