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Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Targeted deletion of integrin-associated protein CD47 enhances long-term engraftment of human CD34⁺ cells in immunodeficient pigs lacking IL2RG and RAG2, enabling large-scale production of functional human immune cells.

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

Sakuranetin is an important phytoalexin. The authors find that sakuranetin in rice attenuates endocytosis of effectors from the fungus Magnaporthe oryzae and enhances resistance against rice blast.

Metabolic dysregulation in the development of clear cell renal cell carcinoma (ccRCC) remains to be understood. Here the authors identify that a carnitine synthesis enzyme BBOX1, which inhibits TBK1-mTORC1 signaling and glycolysis, is often lost in ccRCC.

Tumor-infiltrating regulatory T (TI-T_reg) cells help tumor growth by suppressing local immune responses. Here the authors show that thonzonium bromide can help fight tumors by interfering with the interaction of p97 and Npl4, a complex that they show supports TI-T_reg cells.

Powdery mildew disease seriously threatens wheat production by reducing grain yield and quality. Here, the authors clone the Znf-BED-bearing NLR protein encoding powdery mildew resistance gene Pm6Sl derived from wild wheat species Aegilops longissima and show its application in breeding resistance cultivars.

Upon nutrient stress in hepatocellular carcinoma, the glycolytic enzyme PFKL facilitates mitochondria tethering to lipid droplets to engage lipid mobilization and ensure nutrient supply.

Core fucosylation of N-linked glycoproteins has been linked to physiological and pathological processes. Here, the authors develop a mass spectrometry-based method that utilizes Endo F3 followed by PNGase F treatment to quantify site-specific glycoprotein core fucosylation in protein mixtures.

Low temperature operation of anode-free batteries is limited by poor reversibility of metal plating/stripping. Here, via electrolyte engineering, authors enable −40 °C operation of an anode-free K metal battery by tailoring a weakly solvating electrolyte with a silicone polymer additive.

Despite being a promising treatment for hepatocellular carcinoma (HCC), resistance to tyrosine kinase inhibitors (TKI) present a major obstacle. Here, the authors demonstrate that lipid metabolism reprogramming via URI mediated stearoyl-CoA desaturase 1 upregulation present a targetable driver of sorafenib resistance in HCC.

TERT was dephosphorylated by the protein phosphatase activity of the gluconeogenic enzyme FBP1, leading to inhibition of TERT nuclear translocation and telomere function. Lipid nanoparticle-delivered FBP1 mRNA blunts tumor growth in mice.

Solid polymer electrolytes are commonly used in lithium-metal batteries, but their capacity and energy density cannot be easily increased beyond a charging cut-off voltage of 4.5 V due to the presence of easily oxidized oxygen-bearing polar groups. Here, authors apply a polyfluorinated crosslinker to enhance the oxidation resistance to solve this issue

Th17 cells produce a range of characteristic Th17 type cytokines and express transcription factors governed by epigenetic regulation to engage the Th17 programme. Here the authors implicate the RNA 5- methylcytosine (m⁵C) methyltransferase Nsun2 in Th17 cells and the promotion of colitis in a murine model.

Shao et al. show that EGFR signaling increases expression of the complement regulatory proteins CD55 and CD59, suppressing the complement. This is mediated via a sponging lncRNA and interfering with the axis synergizes with immunotherapy.

Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages in mouse models.

Wu et al. show that, upon activation by insulin-like growth factor 1 receptor and AKT, creatine kinase B exhibits a moonlighting function as protein kinase to phosphorylate glutathione peroxidase 4 to prevent its degradation, thereby suppressing ferroptosis and enhancing tumour growth in mice.

In this work, the authors discovered that Panax species, the valuable medicinal plants, have evolved a two-component chemical defence system comprising a chloroplast-localized β-glucosidase and 20(S)-protopanaxadiol ginsenosides.

Liu et al. demonstrate that CK2 phosphorylates CLOCK to promote its nuclear exportation and cytosolic accumulation, thereby acetylating and stabilizing PRPS1/2 and enhancing de novo nucleotide synthesis to facilitate liver tumour growth.

A competitive-chemical-reaction-based growth mechanism by controlling the kinetic parameters can easily realize the growth of transition metal chalcogenides and transition metal phosphorous chalcogenides with different compositions and phases.

Genome-wide siRNA screens identify an essential function for sorting nexin 5 in virus-induced autophagy and immunity mediated via class III phosphatidylinositol-3-kinase complex 1.

Drug discovery is being transformed by advances in computational protein structure prediction and protein design.

The wave equation established for chiral phononic crystals based reveals only the coupling of acoustic and optic branches, hiding the complexity of the bandgap physics. The alternative method proposed in this paper allows direct observation of the essential physics, and enables to decouple acoustic and optic branches for the manipulation of band gaps.