Production of type-I interferon is regulated by the transcription factor IRF-7. This paper shows that IRF-7 is negatively regulated by translational repressor proteins 4E-BP1 and 4E-BP2. Viral infection promotes mTOR-mediated phosphorylation of the repressor proteins and allows type-I interferon production to proceed.
- Rodney Colina
- Mauro Costa-Mattioli
- Nahum Sonenberg