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Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

The authors report a dual photothermal-electrocatalysis interface which enables efficient ammonia extraction and purification from air and wastewater, thereby advancing sustainable waste-to-fuel conversion.

The authors demonstrate resonant excitation of phonon-polaritons based on THz-driven ZnO single crystals. This clarifies the generation mechanism of phonon-polaritons, enabling their observation for various nonlinear regimes.

Climate warming causes riverine CO₂ emissions increasing at 0.42 ± 0.16 Tg C yr⁻¹ in the Northern Hemisphere permafrost regions during 2000–2020.

Tracing cellular changes in complex biological systems is challenging. Here, authors present a flexible framework that integrates multi-sample data with in-house algorithms to infer comparative and spatiotemporal cell-gene patterns, advancing understanding of cellular dynamics.

Spin-split bands and certain lattice symmetries are required to generate the spin currents needed for spintronics applications. Now a layered room-temperature antiferromagnet is shown to exhibit anisotropic spin splitting between valleys paired by a crystal symmetry.

Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Single-layer NbSe₂ has a charge density wave with two degenerate domains, related by mirror reflection. Here, using scanning tunneling microscopy, the authors observe the time-dependent movement of ___domain walls, and demonstrate reversible switching between the two ___domain types using a voltage pulse from the microscope tip.

The relationship between Mott state and charge density wave state in two dimensional materials remains unclear. Here, Liu et al. reveal spatial distribution of a Mott-Hubbard band in monolayer 1T-NbSe₂ forming a new periodic pattern in addition to the well-known CDW pattern.

Reducing circuit redundancy represents a priority for the scalability of parallel computing hardware. Here, the authors report the realization of pixel processing units consisting of single 2D WSe₂ transistors implementing electrically-switchable logic functions. This strategy enables the fabrication of an image processing array with ~16% transistor consumption compared to traditional circuits.

Low-dose electron microscopy has revealed nonclassical beam damage mechanisms and their descriptive models by enabling real-space visualization of radiation-induced structural dynamics in a metal-organic framework.

Interorgan communications play key roles in the regulation of whole-body energy metabolism. Here, the authors report the myokine Musclin as a negative regulator of beige adipose thermogenesis and systemic energy homeostasis through Tfr1/PKA signalling mediated muscle fat crosstalk.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

Using a polymer stamp with a period arrangement of micro-posts on its surface and a high surface tension liquid, two-dimensional material films can be patterned and transferred on a large-scale with high yield.

The photooxidation of CH₄ to CH₃OH is limited by the availability of reactants at flooded interfaces. Now the authors report a modified metal organic framework nanoreactor to promote the direct photooxidation of CH4 to CH₃OH at the gas-solid interface.

Pt oxides are essential catalysts in many critical reactions, but are typically unstable and prone to evaporation above 700 K. A two-dimensional layered Pt oxide with exceptional thermal stability is introduced, capable of surviving at high temperatures.

Powdery mildew disease seriously threatens wheat production by reducing grain yield and quality. Here, the authors clone the Znf-BED-bearing NLR protein encoding powdery mildew resistance gene Pm6Sl derived from wild wheat species Aegilops longissima and show its application in breeding resistance cultivars.

Molecular electronics or spintronics relies on manipulating the electronic transport through microscopic molecule structures. Here the authors demonstrate the selective electron pathway in single-molecule device by magnetic field which enables a tunable anisotropic magnetoresistance up to 93%.

Metabolic dysregulation in the development of clear cell renal cell carcinoma (ccRCC) remains to be understood. Here the authors identify that a carnitine synthesis enzyme BBOX1, which inhibits TBK1-mTORC1 signaling and glycolysis, is often lost in ccRCC.

The generation of cracks in polycrystalline Ni-rich layered lithium transition metal oxides presents numerous challenges for their use in batteries. Here, authors propose a gradiently distributed pores structure within the oxide secondary particles, reducing internal strain accumulation.

The commercialization of light-emitting diodes based on emissive quantum dots (e.g. QLEDs) is hindered by their inherent poor operational lifetime. Using an intelligent energy-level design strategy, Qian et al. demonstrate QLEDs with operational lifetime that meets industrial display standards.

The reason for a re-emergence of scarlet fever in China remains unclear. Here the authors show that the number of scarlet fever cases surged in 2011 peaking in 2018, this correlates with an increase in NO₂ and O₃ but does not necessarily imply causation.

Tumor-infiltrating regulatory T (TI-T_reg) cells help tumor growth by suppressing local immune responses. Here the authors show that thonzonium bromide can help fight tumors by interfering with the interaction of p97 and Npl4, a complex that they show supports TI-T_reg cells.

The authors highlight the role of acyl coenzyme A binding protein (encoded by DBI) in Cushing’s syndrome by using six different inhibition methods and mapping the physiological effects.

Permafrost soils can be substantial sources of nitrous oxide (N₂O) to the atmosphere, but no data exist on the N₂O footprints of permafrost rivers. Here, the authors show that alpine permafrost rivers are unexpectedly small sources of atmospheric N₂O at present.

An engineered sensor NLR RGA5^HMA5 carrying multiple resurfaced interfaces was generated to confer complete resistance to the rice blast fungus strains expressing the non-corresponding effector AVR-PikD, paving a way to broaden the resistance spectra of NLRs.

Two cyclic dinucleotide molecules bind within the cavity of human SLC19A1 as a compact dual-molecule unit, whereas folate and antifolate bind to SLC19A1 as a monomer and occupy a distinct pocket of the cavity.

Given the association of gut microbiota dysbiosis with hypertriglyceridemic pancreatitis (HTGP), authors assess the gut microbial diversity of patients with HTGP, and provide immunological insight utilising a murine model.

Liu et al. demonstrate that CK2 phosphorylates CLOCK to promote its nuclear exportation and cytosolic accumulation, thereby acetylating and stabilizing PRPS1/2 and enhancing de novo nucleotide synthesis to facilitate liver tumour growth.

A competitive-chemical-reaction-based growth mechanism by controlling the kinetic parameters can easily realize the growth of transition metal chalcogenides and transition metal phosphorous chalcogenides with different compositions and phases.

The prion protein PrP^C is known to play a role in skeletal muscle development and physiology, including in myopathy. Here, the authors report that excess PrP^C binds microRNAs that enhance its aggregation, which inhibits autophagy in muscle cells.

Defects at the perovskite/charge extraction layer interface reduce the performance of solar cells. Yang et al. show that charged oxide interlayers passivate defects by altering charge carrier concentration and their acidity minimizes detrimental reactions.