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Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy

Radiation therapy (RT) can induce immunogenic cell death and elicit anti-tumor immune responses. Here the authors report the design and characterization of a risedronate-manganese-based nanosystem for in situ vaccination, amplifying RT-mediated anti-tumor immunity in preclinical models.

Zhusheng Huang
Shiqian Huang
Lianhui Wang
ResearchOpen Access08 Oct 2024
Nature Communications

Volume: 15, P: 1-20
Non-discriminating engineered masking of immuno-evasive ligands on tumour-derived extracellular vesicles enhances tumour vaccination outcomes

Nano-masking of the surface of tumour-derived extracellular vesicles blocks their immune-evasive action. This improves their phagocytosis by dendritic cells, leading to maturation of T-cell action and culminating in undampened anti-tumour immunity.

Xianguang Ding
JingJing Zhang
Lianhui Wang
Research26 Sept 2024
Nature Nanotechnology

Volume: 20, P: 156-166
Unconventional polarization fatigue in van der Waals layered ferroelectric ionic conductor CuInP₂S₆

The authors find unconventional fatigue characteristics, involving dramatic morphological changes and anomalous polarization enhancement in van der Waals layered ferroelectric CuInP₂S₆, due to a synergic effect of ionic conduction and surface oxidation.

Ziwen Zhou
Shun Wang
Lu You
ResearchOpen Access12 Dec 2023
Nature Communications

Volume: 14, P: 1-10
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

The establishment of a pre-metastatic niche is a key step preceding metastasis formation. Here the authors show that tumor-intrinsic Lin28B, a RNA-binding protein, has an essential role in the formation of an immune-suppressive pre-metastatic niche, promoting lung metastasis of breast cancer.

Meiyan Qi
Yun Xia
Lixing Zhan
ResearchOpen Access16 Feb 2022
Nature Communications

Volume: 13, P: 1-18

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Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy

Non-discriminating engineered masking of immuno-evasive ligands on tumour-derived extracellular vesicles enhances tumour vaccination outcomes

Unconventional polarization fatigue in van der Waals layered ferroelectric ionic conductor CuInP2S6

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

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Unconventional polarization fatigue in van der Waals layered ferroelectric ionic conductor CuInP₂S₆