Nature Search

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease

Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to dysregulated mTOR, cytoskeletal and lipid transport signaling.

Yifei Cai
Jean Kanyo
Jaime Grutzendler
ResearchOpen Access10 Mar 2025
Nature Aging

Volume: 5, P: 504-527
Observation of a thermoelectric Hall plateau in the extreme quantum limit

A sufficiently strong magnetic field drives an electron system into the so-called extreme quantum limit. Zhang et al. demonstrate that in this regime, a Dirac semimetal acquires a robust plateau in the thermoelectric Hall conductivity, with a value independent of magnetic field or electron concentration.

Wenjie Zhang
Peipei Wang
Liyuan Zhang
ResearchOpen Access25 Feb 2020
Nature Communications

Volume: 11, P: 1-5
Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex

The development of translaminar cortical circuits remains incompletely understood. Here authors show cortical layer 5 provides translaminar inputs to layer 2/3 during development, strengthening layer 4-layer 2/3 connections and supporting the formation of the canonical cortical organization in mouse barrel cortex.

John Vargas-Ortiz
Lin Lin
Alicia Che
ResearchOpen Access03 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
The evolutionary road from wild moth to domestic silkworm

Genetic sequencing of 137 silkworm strains enables reconstruction of silkworm domestication history and identifies key genes involved in silk production, circadian rhythms, as well as candidate genes associated with breeding traits.

Hui Xiang
Xiaojing Liu
Shuai Zhan
Research02 Jul 2018
Nature Ecology & Evolution

Volume: 2, P: 1268-1279
Alcohol consumption and risks of more than 200 diseases in Chinese men

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

Pek Kei Im
Neil Wright
Xiaoyi Zhang
ResearchOpen Access08 Jun 2023
Nature Medicine

Volume: 29, P: 1476-1486
Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

Mobile tet(X3) and tet(X4) genes are identified on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated from humans, meat for consumption and animals that confer resistance to tetracyclines, including tigecycline, eravacycline and omadacycline.

Tao He
Ran Wang
Yang Wang
Research27 May 2019
Nature Microbiology

Volume: 4, P: 1450-1456
Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy

Leyang Wu
Zengzheng Du
Zichun Hua
ResearchOpen Access10 Jan 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance

Lu Qiao
Lili Men
Jianling Du
ResearchOpen Access28 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-14
Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults

In a nested case-control study from the China Kadoorie Biobank, lowering blood low-density lipoprotein cholesterol levels confers lower risk for ischemic stroke but elevated risk for intracerebral hemorrhage, which was confirmed by genetic Mendelian randomization analyses.

Luanluan Sun
Robert Clarke
Zhe Qiu
Research11 Mar 2019
Nature Medicine

Volume: 25, P: 569-574
Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis

Xiao Shan
Penghui Hu
Qiujing Yu
Research30 Sept 2022
Cellular & Molecular Immunology

Volume: 19, P: 1263-1278
Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults

Matthew Chun
Robert Clarke
Libo Zhang
ResearchOpen Access02 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Systemic inflammation is associated with incident stroke and heart disease in East Asians

Mohd A. Karim
Christiana Kartsonaki
Libo Zhang
ResearchOpen Access27 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Publisher Correction: Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults

Matthew Chun
Robert Clarke
Libo Zhang
Amendments and CorrectionsOpen Access18 Oct 2021
Scientific Reports

Volume: 11, P: 1
Publisher Correction: Systemic inflammation is associated with incident stroke and heart disease in East Asians

Mohd A. Karim
Christiana Kartsonaki
Libo Zhang
Amendments and CorrectionsOpen Access12 May 2020
Scientific Reports

Volume: 10, P: 1-2

Search

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease

Observation of a thermoelectric Hall plateau in the extreme quantum limit

Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex

Human lifespan changes in the brain’s functional connectome

The evolutionary road from wild moth to domestic silkworm

Alcohol consumption and risks of more than 200 diseases in Chinese men

Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy

Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults

Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis

Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults

Systemic inflammation is associated with incident stroke and heart disease in East Asians

Publisher Correction: Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults

Publisher Correction: Systemic inflammation is associated with incident stroke and heart disease in East Asians

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