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Showing 1–11 of 11 results
Advanced filters: Author: Lizeng Gao Clear advanced filters

  • Iron-based nanozymes are promising for tumor catalytic therapy owing to their biocompatibility and peroxidase-like activity, but the concurrent catalase-like activity undermines the therapeutic efficacy. Here, the authors address this issue by developing a hemin–cysteine–Fe nanozyme, which exhibits catalytic selectivity and exclusive peroxidase-like activity.

    • Shuaibing Zhang
    • Xuejiao J. Gao
    • Bing Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Natural antimicrobial peptides and enzymes are good candidates for application but suffer from low stability. Here, the authors report on biomimetic self-assembling peptides which mimic both antimicrobial peptide and enzyme functionality, demonstrating application against fungal infection.

    • Ye Yuan
    • Lei Chen
    • Lizeng Gao
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Emulating the killing function of neutrophils, which involves the enzymatic cascade of superoxide dismutase (SOD) and myeloperoxidase (MPO), is promising for cancer therapy, but developing SOD-MPO cascade in one nanozyme is challenging. Here the authors report ultrasmall AuPd alloy nanozymes that mimic neutrophil enzymatic cascades for catalytic treatment of tumors.

    • Xiangqin Meng
    • Huizhen Fan
    • Kelong Fan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Designing and enhancing the performance of metal single-atom nanozymes (SAzymes) through atom-pair engineering is important yet difficult. Here the authors develop the atom-pair engineering of Zn-SA/CNCl SAzyme by concurrently creating Zn-N4 sites as catalytic sites and Zn-N4Cl1 sites as catalytic regulators.

    • Shengjie Wei
    • Wenjie Ma
    • Yadong Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Enveloped viruses encased within a lipid bilayer membrane are highly contagious and cause diseases like influenza and COVID-19, so strategies for their prevention and inactivation are needed. Here, the authors develop a diatomic iron nanozyme with lipoxidase-like activity for the inactivation of enveloped viruses, where the diatomic iron sites destroy the viral envelope via lipid peroxidation.

    • Beibei Li
    • Ruonan Ma
    • Yadong Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • In this work, the authors report that Histidine residues play a critical role in modulating amyloid-like assembly and building active sites for Fmoc–F–F and Aβ aggregates. Aβ1-42 filaments were found to perform peroxidase-like activity to enhance oxidative stress, which might also be ascribed to the interaction mode of His and F-F.

    • Ye Yuan
    • Lei Chen
    • Lizeng Gao
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • If decorated with the right surface modifications, nanoparticles can function as Trojan horses, transporting cell death-facilitating compounds to tumor cells. Here, the authors prepare a particle with four enzyme-like activities and show that ferritin can direct nanoparticles to tumor cells.

    • Kelong Fan
    • Juqun Xi
    • Lizeng Gao
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Nanozymes are nanomaterials that exert biocatalytic functions within biological systems. This Review discusses the design criteria and mechanisms of nanozymes for in vivo applications to treat different pathological disorders.

    • Ruofei Zhang
    • Bing Jiang
    • Xiyun Yan
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 849-868