The E1A binding protein p300 and its close paralogue CREB-binding protein are transcriptional coactivators with intrinsic histone acetyltransferase activity. Here, the authors show that the TAZ2 ___domain of p300 has a HAT autoinhibitory function that is relieved upon binding of transcription factors.
- Longxia Xu
- Hongwen Xuan
- Xiaobing Shi
