Nature Search

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Amy R. Bentley
Yun J. Sung
L. Adrienne Cupples
Research29 Mar 2019
Nature Genetics

Volume: 51, P: 636-648
The trans-ancestral genomic architecture of glycemic traits

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Ji Chen
Cassandra N. Spracklen
Cornelia van Duijn
Research31 May 2021
Nature Genetics

Volume: 53, P: 840-860
A phase 1b randomised clinical trial evaluating BBI-001, a non-absorbed oral therapeutic for the treatment of iron overload

Curtis Scribner
Jamie Cope
Cory Berkland
ResearchOpen Access17 May 2025
Scientific Reports

Volume: 15, P: 1-8
Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Asexual vertebrates are extremely rare. Here, the authors sequence the genome of the Amazon molly, an asexual fish, and find few signs of genetic degeneration but clonal polymorphism and high heterozygosity, which might explain the success of this species.

Wesley C. Warren
Raquel García-Pérez
Manfred Schartl
ResearchOpen Access12 Feb 2018
Nature Ecology & Evolution

Volume: 2, P: 669-679
Hidden 19S IgM Rheumatoid Factor in Juvenile Rheumatoid Arthritis

Terry L Moore
Robert W Dorner
Jack Zuckner
Research01 Oct 1980
Pediatric Research

Volume: 14, P: 1135-1138
Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson’s disease risk

Using whole-exome sequencing followed by in vitro enzymatic assays, Chew, Liu, Li, Chung et al. identified rare protein-coding variants in GBA1 and SMPD1 that significantly associate with risk of Parkinson’s disease across cohorts of Asian descent.

Elaine GY Chew
Zhehao Liu
Jia Nee Foo
ResearchOpen Access21 Nov 2024
Nature Aging

Volume: 5, P: 205-218
MATERNO-FETAL TRANSFER OF THYROXINE (T₄): MATERNAL (M) AND FETAL (F) FREE T₄ (FT₄) RELATIONSHIP AND THYROMIMETIC EFFECTS IN THE FETUS

U Devaskar
S Devaskar
P Grim
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 151
Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

Georges Imbert
Frédéric Saudou
Alexis Brice
Research01 Nov 1996
Nature Genetics

Volume: 14, P: 285-291
Early Release Science of the exoplanet WASP-39b with JWST NIRISS

The transmission spectrum of the exoplanet WASP-39b is obtained using observations from the Single-Object Slitless Spectroscopy mode of the Near Infrared Imager and Slitless Spectrograph instrument aboard the JWST.

Adina D. Feinstein
Michael Radica
Xi Zhang
ResearchOpen Access09 Jan 2023
Nature

Volume: 614, P: 670-675
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Identification of constrained sequence elements across 239 primate genomes

Whole-genome alignment of 239 primate species reveals noncoding regulatory elements that are under selective constraint in primates but not in other placental mammals, that are enriched for variants that affect human gene expression and complex traits in diseases.

Lukas F. K. Kuderna
Jacob C. Ulirsch
Kyle Kai-How Farh
ResearchOpen Access29 Nov 2023
Nature

Volume: 625, P: 735-742
Radial symmetry in a chimeric glutamate receptor pore

Crystallographic studies have shown that non-NMDA glutamate receptors exhibit fourfold symmetry in the transmembrane ___domain in the closed state; however, structural data regarding channel opening is lacking. Using chimeric receptors, Wilding et al.provide evidence that this fourfold symmetry is maintained in the open state.

Timothy J. Wilding
Melany N. Lopez
James E. Huettner
Research24 Feb 2014
Nature Communications

Volume: 5, P: 1-10
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell carcinoma tumors. They identify novel significantly mutated genes and amplification peaks and find that around half of the tumors have at least five predicted neoepitopes.

Joshua D Campbell
Anton Alexandrov
Matthew Meyerson
Research09 May 2016
Nature Genetics

Volume: 48, P: 607-616
GLYCOGEN PHOSPHORYLASE (GP) STIMULATION BY VASOPRESSIN (V), ANGIOTENSIN II (A2), GLUCAGON (GLU) AND A23187 IN NEWBORN HEPATOCYTES

A Noguchi
P Jett
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 157
Architectural Representation of Valence in the Limbic System

Praneeth Namburi
Ream Al-Hasani
Kay M Tye
Reviews09 Dec 2015
Neuropsychopharmacology

Volume: 41, P: 1697-1715
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

UDP-glucuronic acid is a component of the extracellular matrix. Here, the authors report biallelic variants in the gene encoding UDP-Glucose 6-Dehydrogenase (UGDH) in individuals affected by developmental epileptic encephalopathies that impair UGDH stability, oligomerization, or enzymatic activity in vitro.

Holger Hengel
Célia Bosso-Lefèvre
Bruno Reversade
ResearchOpen Access30 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line

J M Cheverud
H A Lawson
E Heber-Katz
Research26 Feb 2014
Heredity

Volume: 112, P: 508-518
MALIGNANT OSTEOPETROSIS(OP): OBSERVATIONS ON THE DISEASE SPECTRUM

B R Blazar
S L Teitelbaum
D M Brown
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 291
Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors

Raja R Seethala
Lester D R Thompson
Manju L Prasad
Research02 Sept 2011
Modern Pathology

Volume: 25, P: 26-35
HLA alleles in relation to specific immunity to Liver Stage Antigen-1 from Plasmodium falciparum in Gabon

F Migot-Nabias
AJF Luty
P Deloron
Research25 Mar 2001
Genes & Immunity

Volume: 2, P: 4-10
A systematic review and meta-analysis of obesity and COVID-19 outcomes

Xinya Zhang
Alexander M. Lewis
Jonathan R. Brestoff
ResearchOpen Access30 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology

Lutnick et al. develop a cloud-based deep learning tool for whole slide image segmentation. The authors provide several examples of its application in renal pathology, for segmenting glomeruli, interstitial fibrosis and other features of interest.

Brendon Lutnick
David Manthey
Angela Victoria-Castro
ResearchOpen Access19 Aug 2022
Communications Medicine

Volume: 2, P: 1-15
Group II Metabotropic Glutamate Receptor Agonist Ameliorates MK801-Induced Dysfunction of NMDA Receptors via the Akt/GSK-3β Pathway in Adult Rat Prefrontal Cortex

Dong Xi
Yan-Chun Li
Wen-Jun Gao
Research16 Feb 2011
Neuropsychopharmacology

Volume: 36, P: 1260-1274
Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Rita Alaggio
Catalina Amador
Wei-Li Zhao
Amendments and CorrectionsOpen Access19 Jul 2023
Leukemia

Volume: 37, P: 1944-1951
Low Levels of Fruit Nitrogen as Drivers for the Evolution of Madagascar’s Primate Communities

Giuseppe Donati
Luca Santini
Jörg U. Ganzhorn
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-9

Search

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

The trans-ancestral genomic architecture of glycemic traits

A phase 1b randomised clinical trial evaluating BBI-001, a non-absorbed oral therapeutic for the treatment of iron overload

Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Hidden 19S IgM Rheumatoid Factor in Juvenile Rheumatoid Arthritis

Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson’s disease risk

MATERNO-FETAL TRANSFER OF THYROXINE (T₄): MATERNAL (M) AND FETAL (F) FREE T₄ (FT₄) RELATIONSHIP AND THYROMIMETIC EFFECTS IN THE FETUS

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

Early Release Science of the exoplanet WASP-39b with JWST NIRISS

Diminishing benefits of urban living for children and adolescents’ growth and development

Identification of constrained sequence elements across 239 primate genomes

Radial symmetry in a chimeric glutamate receptor pore

Repositioning of the global epicentre of non-optimal cholesterol

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

GLYCOGEN PHOSPHORYLASE (GP) STIMULATION BY VASOPRESSIN (V), ANGIOTENSIN II (A2), GLUCAGON (GLU) AND A23187 IN NEWBORN HEPATOCYTES

Architectural Representation of Valence in the Limbic System

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line

MALIGNANT OSTEOPETROSIS(OP): OBSERVATIONS ON THE DISEASE SPECTRUM

Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors

HLA alleles in relation to specific immunity to Liver Stage Antigen-1 from Plasmodium falciparum in Gabon

A systematic review and meta-analysis of obesity and COVID-19 outcomes

A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology

Group II Metabotropic Glutamate Receptor Agonist Ameliorates MK801-Induced Dysfunction of NMDA Receptors via the Akt/GSK-3β Pathway in Adult Rat Prefrontal Cortex

Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Low Levels of Fruit Nitrogen as Drivers for the Evolution of Madagascar’s Primate Communities

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