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Showing 1–8 of 8 results
Advanced filters: Author: Luni Hu Clear advanced filters

  • Metabolic processes lead to the production of bioactive gases, such as nitric oxide, which may play roles in the gut immune homeostasis. Here authors show that genomic deletion of Nos2 in mice aggravates colitis in experimental models via an Aryl-Hydrocarbon-Receptor-mediated pathway in type 3 innate lymphoid cells.

    • Xingyu Zhao
    • Jun Li
    • Chao Zhong
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Existing 3D Spatial Transcriptomics reconstruction approaches often overlook spatial information or experiment-induced distortions. Here, authors propose ST-GEARS to bridge the gap between in vivo cell locations and in vitro analysis, accurately recovering spatial profiles.

    • Tianyi Xia
    • Luni Hu
    • Shuangsang Fang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Uterine natural killer (NK) cells support tissue homeostasis in the uterus during pregnancy, but it is not fully known how they differentiate into potentially cytotoxic effector cells while avoiding tissue damage. Here authors show that Il21 receptor signalling via STAT3 activation governs their differentiation, while an apoptotic cell death program ensures that harm is limited.

    • Mengwei Han
    • Luni Hu
    • Chao Zhong
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Defects in interleukin-22 production and group 3 innate lymphoid cells are correlated with aggravated gut inflammation. Wu et al. find that proline uptake via the proline transporter Slc6a7 is involved in activation of lymphoid tissue inducer cells and interleukin-22 production in the gut, and that dietary supplementation with proline alleviates colitis in a mouse model.

    • Di Wu
    • Zongxian Li
    • Chao Zhong
    Research
    Nature Metabolism
    Volume: 5, P: 1953-1968

  • The contribution of cell-extrinsic factors during cellular reprogramming to human induced pluripotent stem cells has long been overlooked. Here, the authors show functional protein communication between reprogramming intermediates and the re-shaping of a permissive extracellular environment.

    • Francesco Panariello
    • Onelia Gagliano
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic and small intestinal organoids.

    • Giovanni Giuseppe Giobbe
    • Claire Crowley
    • Paolo De Coppi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14