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How signaling pathways recruit SWI/SNF chromatin remodeling complexes is not known. Here the authors suggest a ubiquitin directed mechanism targeting SWI/SNF for Wnt pathway dependent transcription, important for development and cancer.

Mobile impurities can be useful probes of quantum states. Here, the authors theoretically identify polarons formed on the edge of topological insulating states, termed chiral polarons, that can be used to probe topological matter.

Modern vision-based language models face challenges with complex physical interactions, causal reasoning and intuitive psychology. Schulze Buschoff and colleagues demonstrate that while some models exhibit proficient visual data processing capabilities, they fall short of human performance in these cognitive domains.

Slice-and-view scanning electron microscopy tomography is used to characterize a double-gyroid block copolymer, finding mesoatomic distortions that break the symmetry of these soft-matter crystals across multiple scales.

The human ADAR enzyme can deaminate additional transcripts for therapeutic A-to-G RNA base editing using an antisense guide RNA. Here, authors engineer a universal guide RNA scaffold from the U7 snRNA, boosting editing efficiency from minimal doses, especially in organs with limited AAV delivery.

MeshHeart, a conditional generative model for time-resolved 3D heart mesh generation, is proposed by Qiao et al. to unravel heart motion patterns. Their findings could advance diagnosis and treatment strategies for cardiovascular diseases.

Mammary gland resident macrophages are known to be crucial components of the mammary stem cell niche. Here, the authors show that CXCR4⁺ macrophages form a niche that regulates the tumor-initiating activity of breast cancer cells and induces early immune evasion through the recruitment of regulatory T cells.

This opium poppy mutant provides chemical precursors for non-addictive analgesics.

The neural mechanism responsible for context inference remains unknown. Here, the authors show that a PFC-MD neural network with a Hebbian plasticity rule achieves rapid online context inference and alleviates catastrophic forgetting.

Colour code on a superconducting qubit quantum processor is demonstrated, reporting above-breakeven performance and logical error scaling with increased code size by a factor of 1.56 moving from distance-3 to distance-5 code.

Sustainable management of soil organic carbon (SOC) in farmland is critical for mitigating climate change and improving soil health. Degradable film mulching is a promising alternative to plastic film mulching, sequestering SOC and reducing C loss in dryland agroecosystems under climate change.

The AcP10 protein—an active uridine kinase, encoded by the beluga whale coronavirus SW1—is an antagonist of the integrated stress response that acts downstream of phosphorylation of the translation initiation factor eIF2, irrespective of which eIF2 kinase is activated. AcP10 acts as a competitive inhibitor of the eIF2[P]–eIF2B interaction by binding to eIF2B. A protein with a similar function is also encoded by Aichivirus, a picornavirus.

Block copolymer self-assembly can successfully generate monolayers of complex nanopatterns. Here, the authors orthogonally self-assemble 2 or 3 layers of distinct molecular weight block copolymers, and fabricate complex nanomesh structures without alignment or high-resolution lithographic templating.

Biofluorescence is widespread in fishes. Here, the authors compile data on biofluorescence presence across teleost fishes and demonstrate that it may have originally evolved in eels 112 million years ago, but evolved numerous other times as well, often in association with coral reefs.

PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.

The oocyte-to-embryo transition marks the beginning of development but the mechanisms underlying this process are incompletely described. Here they show that PRDM10 activates Septin11 and is required for progression through the oocyte-to-embryo transition.

Analysis of a fossil trackway from the earliest Carboniferous of Australia shows prints of toes with claws, suggesting that the origin of amniotes was at least 35–40 million years earlier than previously thought.

Defects in materials can be used to detect magnetic fields at the nanoscale. Here the authors show that a carbon-related defect in hexagonal boron nitride acts as a robust nanoscale sensor capable of vectorial magnetic field detection.

Sosa et al. find that hippocampal neural activity in mice encodes both environmental ___location and experience relative to rewards, spanning distances far from reward, through parallel and flexible population-level codes.

Three-dimensional films — comprising polymeric phases of different molecular weights and compositions — are arranged in complex hierarchical patterns and used for wafer-scale patterning.

The PhoQ/PhoP system regulates antimicrobial peptide defense in bacteria. Here the authors show that at sublethal concentrations of antimicrobial peptides, PhoPQ induces QueE, that then localizes to the divisome and blocks cell division independently of its function in queuosine biosynthesis.

The relationship between lipid dyshomeostasis and tau pathology in FTLD and AD remains unclear. Here, the authors demonstrate that GRAMD1B contributes to lipid dyshomeostasis, autophagy impairment, and tau hyperphosphorylation in neurons.

The Messinian Salinity Crisis occurred during extensional lithospheric delamination, with the demise of the crisis driven by slab detachment around 5 Ma, according to U-Pb dating and clumped isotopes from calcite veins in an eastern Betic basin.

Generation and analysis of high-quality, genome assemblies from Middle Eastern trios demonstrate the utility of ancestry-matched data and assembly-based variation analysis.

A luminescence cascade system achieves 500-fold higher intensity and 8-fold longer signal persistence than conventional bioluminescence assays, enabling reliable and effective use of bioluminescence for point-of-care diagnostics.

Basal Pancreatic Ductal Adenocarcinoma (PDAC) is more aggressive than the classical subtype of pancreatic cancer. Here the authors report that RNA-binding protein LIN28B and its target HMGA2 drive basal PDAC pathogenesis by reducing PP2A methylation and activity, resulting in enhanced protein synthesis and aggressive features.

Oby, Degenhart, Grigsby and colleagues used a brain–computer interface to challenge monkeys to override their natural time courses of neural activity. They found the time courses to be highly robust, suggestive of network-level computational mechanisms.

A large-scale multi-omics analysis reports oncogenic alterations that drive medulloblastoma progression, rather than initiation, and the findings show how single-cell technologies can be used for early detection and diagnosis of medulloblastoma.

The associations between gut metabolites, brain activity, and behavior in youth with autism is unclear. Here authors show that some tryptophan metabolites are different in autism and are associated with autism symptoms and activity in interoceptive brain regions.

ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

In CHIP, somatic mutations in a hematopoietic stem cell lead to a clonal subpopulation of blood cells. Here, the authors perform a CHIP meta-EWAS to establish its epigenetic features and age-related outcomes.

In a large-scale analysis of ambulatory electrocardiographic recordings, a deep learning algorithm had a substantially higher sensitivity for the detection of critical arrhythmias as compared to technicians, opening a path toward artificial intelligence-assisted direct-to-physician reporting of ambulatory electrocardiography results.

Here, Gatica et al show that FAM134B, which resides in the endoplasmic reticulum, can be targeted by and limited by Salmonella enterica serovar Typhimurium. This results in restriction of selective autophagy of the endoplasmic reticulum and enhances bacterial survival within host cells.

Small water droplets within larger oil droplets, which are themselves distributed in an aqueous phase, are a type of double emulsion. This paper details that double emulsions can prepared and stabilized over several months using amphiphilic diblock copolypeptides, and can even generate robust double nanoemulsions.