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Showing 51–82 of 82 results

Advanced filters: Author: MICHAEL GOUGH Clear advanced filters

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Epigenetic changes are implicated in Acute myeloid leukemia (AML) tumorigenesis. Here, the authors show that the ubiquitin ligase RNF5 and its substrate RBBP4 contribute to AML development by regulating epigenetic-controlled transcription which determines AML sensitivity to HDAC inhibitors.

Ali Khateb
Anagha Deshpande
Ze’ev A. Ronai
ResearchOpen Access13 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Bright radio emission from an ultraluminous stellar-mass microquasar in M 31

A new ultraluminous X-ray source has been discovered in M 31, whose variability and associated bright, compact radio emission identify it as a stellar-mass black hole accreting close to the Eddington limit.

Matthew J. Middleton
James C. A. Miller-Jones
Keith Grainge
Research12 Dec 2012
Nature

Volume: 493, P: 187-190
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

New methods and larger sample groups are used to precisely determine the alleles in the HLA complex which contribute susceptibility to type 1 diabetes.

Sergey Nejentsev
Joanna M. M. Howson
Jane Worthington
Research14 Nov 2007
Nature

Volume: 450, P: 887-892
A compact and cost-effective hard X-ray free-electron laser driven by a high-brightness and low-energy electron beam

The first lasing results at SwissFEL, an X-ray free-electron laser, are presented, highlighting the facility’s unique capabilities. A general comparison to other major facilities is also provided.

Eduard Prat
Rafael Abela
Elke Zimoch
Research09 Nov 2020
Nature Photonics

Volume: 14, P: 748-754
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

New animal models of Zika virus (ZIKV) infection are imperative to accelerating efforts to treat or prevent disease in humans. Adams Waldorf et al. now report that ZIKV infection of a pregnant female pigtailed macaque caused brain lesions in the developing fetus, suggesting that this model may be useful for understanding ZIKV-associated congenital abnormalities in humans.

Kristina M Adams Waldorf
Jennifer E Stencel-Baerenwald
Lakshmi Rajagopal
Research12 Sept 2016
Nature Medicine

Volume: 22, P: 1256-1259
Design of amidobenzimidazole STING receptor agonists with systemic activity

A small-molecule agonist for the cGAS–STING pathway has systemic activity in a mouse model of colon cancer.

Joshi M. Ramanjulu
G. Scott Pesiridis
John Bertin
Research07 Nov 2018
Nature

Volume: 564, P: 439-443
A large-scale evaluation of computational protein function prediction

A report on the results of the first large-scale community-based critical assessment of protein function annotation (CAFA) experiment.

Predrag Radivojac
Wyatt T Clark
Iddo Friedberg
ResearchOpen Access27 Jan 2013
Nature Methods

Volume: 10, P: 221-227
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

Harukazu Suzuki
Alistair R R Forrest
Yoshihide Hayashizaki
Research19 Apr 2009
Nature Genetics

Volume: 41, P: 553-562
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain

Zika virus infection of pregnant nonhuman primates results in the loss of fetal neuronal progenitor cells, even in the absence of overt microcephaly.

Kristina M Adams Waldorf
Branden R Nelson
Lakshmi Rajagopal
Research05 Feb 2018
Nature Medicine

Volume: 24, P: 368-374
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

Regeneration of the heart muscle after myocardial infarction with cardiomyocytes derived from human embryonic stem cells is demonstrated in non-human primates, with the grafts showing evidence of electromechanical coupling, although they were also associated with non-fatal arrhythmias.

James J. H. Chong
Xiulan Yang
Charles E. Murry
Research30 Apr 2014
Nature

Volume: 510, P: 273-277
Ryk is expressed in a differentiation-specific manner in epithelial tissues and is strongly induced in decidualizing uterine stroma

Michael S Serfas
Angela L Tyner
Research13 Jan 1999
Oncogene

Volume: 17, P: 3435-3444
Expression and function of members of the cytokine receptor superfamily on breast cancer cells

Andrea M Douglas
Geraldine A Goss
C Glenn Begley
Research13 Feb 1997
Oncogene

Volume: 14, P: 661-669
Fluorescence tracking demonstrates T cell recirculation is transiently impaired by radiation therapy to the tumor

Gwen Kramer
Tiffany Blair
Michael J. Gough
ResearchOpen Access24 May 2024
Scientific Reports

Volume: 14, P: 1-13
A novel small molecule Enpp1 inhibitor improves tumor control following radiation therapy by targeting stromal Enpp1 expression

Jason R Baird
Alejandro F Alice
Michael J Gough
ResearchOpen Access02 Dec 2024
Scientific Reports

Volume: 14, P: 1-17
Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington’s Disease Model through the Application of Quantitative Systems Pharmacology

Fen Pei
Hongchun Li
Mark E. Schurdak
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-16
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

A search for variants in coding exons of 25 genome-wide association study risk genes in a large cohort of autoimmune patients finds that rare coding-region variants at known loci have a negligible role in common autoimmune disease susceptibility, arguing against the previously proposed rare-variant synthetic genome-wide association hypothesis.

Karen A. Hunt
Vanisha Mistry
David A. van Heel
Research22 May 2013
Nature

Volume: 498, P: 232-235
Estimating the effect size of surgery to improve walking in children with cerebral palsy from retrospective observational clinical data

Apoorva Rajagopal
Łukasz Kidziński
Michael H. Schwartz
ResearchOpen Access05 Nov 2018
Scientific Reports

Volume: 8, P: 1-11
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
Amendments and CorrectionsOpen Access02 May 2023
Nature Biotechnology

Volume: 41, P: 1026
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control

Tiffany Blair
Jason Baird
Marka R. Crittenden
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-13
Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity

Marka R. Crittenden
Lauren Zebertavage
Michael J. Gough
ResearchOpen Access03 May 2018
Scientific Reports

Volume: 8, P: 1-15
Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity

Lauren K. Zebertavage
Alejandro Alice
Michael J. Gough
ResearchOpen Access30 Apr 2020
Scientific Reports

Volume: 10, P: 1-14
Towards Engineering Proteins by Site-Directed Incorporation In Vivo of Non-Natural Amino Acids

Michael Ibba
Hauke Hennecke
Research01 Jul 1994
Bio/Technology

Volume: 12, P: 678-682
Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2

Annette Hogg
Sabine Schirm
Thomas J Gonda
Research11 Dec 1997
Oncogene

Volume: 15, P: 2885-2898
Experimental and in silico evidence suggests vaccines are unlikely to be affected by D614G mutation in SARS-CoV-2 spike protein

Alexander J. McAuley
Michael J. Kuiper
S. S. Vasan
ResearchOpen Access08 Oct 2020
npj Vaccines

Volume: 5, P: 1-5
PKC-δ is an apoptotic lamin kinase

Timothy Cross
Gareth Griffiths
Janet M Lord
Research15 May 2000
Oncogene

Volume: 19, P: 2331-2337
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto Romagnoni
Simon Jégou
Pamela Whittaker
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-18
Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production

Alejandro F. Alice
Gwen Kramer
Marka R. Crittenden
ResearchOpen Access11 Aug 2021
Scientific Reports

Volume: 11, P: 1-19
Immunotherapy for murine K1735 melanoma: Combinatorial use of recombinant adenovirus expressing CD40L and other immunomodulators

Isabelle Peter
Michael Nawrath
Silvio Hemmi
Research14 Jun 2002
Cancer Gene Therapy

Volume: 9, P: 597-605
N-Substituted Piperazines Abused by Humans Mimic the Molecular Mechanism of 3,4-Methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’)

Michael H Baumann
Robert D Clark
Richard B Rothman
Research20 Oct 2004
Neuropsychopharmacology

Volume: 30, P: 550-560
The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

Gilberto Pastorello
Carlo Trotta
Dario Papale
ResearchOpen Access09 Jul 2020
Scientific Data

Volume: 7, P: 1-27
Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

Gilberto Pastorello
Carlo Trotta
Dario Papale
Amendments and CorrectionsOpen Access25 Feb 2021
Scientific Data

Volume: 8, P: 1-2

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