Extracellular mRNAs are found to play an important role in premetastatic organs. Here this group reports the non-vesicular extracellular IL1β-mRNA complexes binding to ZC3H12D followed by the translocation into nucleus without being translated, thereby killing NK cells/CTLs and inhibiting lung metastasis in a preclinical colon cancer model.
- Hikaru Hayashi
- Sayaka Seki
- Sachie Hiratsuka
