Nature Search

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Author Correction: Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Raffaella Rossin
Ron M. Versteegen
Marc S. Robillard
Amendments and CorrectionsOpen Access16 Jan 2019
Nature Communications

Volume: 10, P: 1
Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry

The bioorthogonal tetrazine-triggered cleavage of trans-cyclooctene-linked payloads has strong potential in click-to-release drug delivery, however, an inverse correlation between click reactivity and payload release yield is hampering their clinical translation. Here, the authors develop ortho-substituted bis-pyridinyl-tetrazines with hydrogen-bonding hydroxyl or amido groups for efficient tautomerization and payload elimination, achieving release yields of 96% with 18-fold more reactive tetrazines.

Ron M. Versteegen
Raffaella Rossin
Marc S. Robillard
ResearchOpen Access19 Dec 2024
Communications Chemistry

Volume: 7, P: 1-9
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger.

Raffaella Rossin
Ron M. Versteegen
Marc S. Robillard
ResearchOpen Access04 May 2018
Nature Communications

Volume: 9, P: 1-11
Bioorthogonal chemistry

The underlying mechanisms and optimal conditions that drive biorthogonal reactions and the utility of these for applications in medicinal chemistry and protein synthesis to polymers and materials science are described in this Primer. Current reproducibility standards and how current reaction limitations are driving new research efforts are also discussed.

Samuel L. Scinto
Didier A. Bilodeau
Joseph M. Fox
Reviews15 Apr 2021
Nature Reviews Methods Primers

Volume: 1, P: 1-23
Author Correction: Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry

Ron M. Versteegen
Raffaella Rossin
Marc S. Robillard
Amendments and CorrectionsOpen Access31 Dec 2024
Communications Chemistry

Volume: 7, P: 1
Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia

Rémi Letestu
Abdelmalek Dahmani
Henry Jardel
Research15 Sept 2020
Leukemia

Volume: 35, P: 1597-1609
Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain

Sara Elramah
María José López-González
Alexandre Favereaux
ResearchOpen Access08 Sept 2017
Scientific Reports

Volume: 7, P: 1-13

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