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Metabolites as agents and targets for cancer immunotherapy

Tumour cells undergo profound changes in their metabolism, but targeting these metabolic pathways requires understanding of the impact on immune cells as well as cancer cells. This Review discusses how metabolic pathways in cancer and immune cells shape the tumour microenvironment and describes metabolic modulators and dietary nutrients developed to improve the anticancer immune response.

Marcel P. Trefny
Guido Kroemer
Sebastian Kobold
Reviews26 Jun 2025
Nature Reviews Drug Discovery

P: 1-21
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that SNX9 knockout is associated with improved T cell function and anti-tumor activity in preclinical cancer models.

Marcel P. Trefny
Nicole Kirchhammer
Alfred Zippelius
ResearchOpen Access02 Feb 2023
Nature Communications

Volume: 14, P: 1-21
Author Correction: Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

Ana Luísa Correia
Joao C. Guimaraes
Mohamed Bentires-Alj
Amendments and Corrections11 Nov 2021
Nature

Volume: 600, P: E7
A transcriptionally and functionally distinct PD-1⁺ CD8⁺ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Tumor-infiltrating CD8⁺ T cells with high expression of PD-1 in non-small-cell lung cancer are distinct from exhausted T cells in chronic virus infection, have high tumor reactivity and associate with response to PD-1-targeted immunotherapy.

Daniela S. Thommen
Viktor H. Koelzer
Alfred Zippelius
Research11 Jun 2018
Nature Medicine

Volume: 24, P: 994-1004
Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

Liver-resident natural killer (NK) cells sustain the dormancy of disseminated breast cancer cells, and a decrease in NK cells and increase in activated hepatic stellate cells is associated with the formation of liver metastases.

Ana Luísa Correia
Joao C. Guimaraes
Mohamed Bentires-Alj
Research02 Jun 2021
Nature

Volume: 594, P: 566-571
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Tumor environments are highly acidic due to high concentrations of lactic acid. Ho and colleagues report that tumor-infiltrating regulatory T cells adapt to this tumor environment by upregulating expression of CD36, which allows them to use fatty acids to fuel their metabolism.

Haiping Wang
Fabien Franco
Ping-Chih Ho
Research17 Feb 2020
Nature Immunology

Volume: 21, P: 298-308
Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential

He Liu
Zhaoyue He
Hans-Uwe Simon
Research28 Aug 2018
Cell Death & Differentiation

Volume: 26, P: 1048-1061

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Metabolites as agents and targets for cancer immunotherapy

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

Author Correction: Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

A transcriptionally and functionally distinct PD-1⁺ CD8⁺ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential

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Metabolites as agents and targets for cancer immunotherapy

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

Author Correction: Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential

Search

Quick links

A transcriptionally and functionally distinct PD-1⁺ CD8⁺ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade