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Showing 1–2 of 2 results
Advanced filters: Author: Marco Peronaci Clear advanced filters

  • SETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regulate transcription.

    • Rocco Piazza
    • Vera Magistroni
    • Carlo Gambacorti-Passerini
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell differentiation forming a regulatory loop that could underlie TSC tumorigenesis.

    • Jun-Hung Cho
    • Bhaumik Patel
    • Magdalena Karbowniczek
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16