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Showing 1–6 of 6 results
Advanced filters: Author: Margot P. Scheffer Clear advanced filters

  • The adhesion complex (Nap) in Mycoplasma genitalium is composed of the adhesin proteins P110 and P140 and essential for infectivity, motility and adhesion of this human pathogen. Here, the author present the structures of P140 alone and the P140/P110 complex in closed and open conformations and based on their structural data and further functional studies propose a mechanism for the attachment and release of M. genitalium to the host cell receptor.

    • David Aparicio
    • Margot P. Scheffer
    • Achilleas S. Frangakis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Evan Eichler and colleagues report an expanded copy number variation (CNV) morbidity map of developmental delay, with additional resequencing of candidate genes in regions implicated by large CNVs. They identify several new disease-associated CNVs and show how their combined approach facilitates discovery of new developmental syndromes and disease genes.

    • Bradley P Coe
    • Kali Witherspoon
    • Evan E Eichler
    Research
    Nature Genetics
    Volume: 46, P: 1063-1071

  • M. pneumoniae, a model organism for a minimal cell, has a dedicated protein, namely P116, to specifically extract essential lipids. The structure of P116 has a previously unseen fold, resembling a left-handed baseball glove forming a huge hydrophobic cavity.

    • Lasse Sprankel
    • David Vizarraga
    • Achilleas S. Frangakis
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 321-329

  • Adhesion of the human pathogen Mycoplasma pneumoniae to pulmonary epithelial cells is mediated by a transmembrane complex composed of proteins P1 and P40/P90. Here, the authors present the structures of M. pneumoniae P1 and P40/P90, show that P40/P90 binds sialylated oligosaccharides and have also determined the crystal structures of P40/P90 complexes with 3’-Sialyllactose and 6’-Sialyllactose, which provide insights into the mechanisms of adhesion and gliding on host cell surfaces.

    • David Vizarraga
    • Akihiro Kawamoto
    • David Aparicio
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Dimmeler and colleagues show that the atheroprotective transcription factor KLF2 activates expression of the microRNAs miR-143/145 in endothelial cells. miR-143/145 are subsequently enriched in secreted microvesicles and taken up by smooth muscle cells to elicit anti-atherogenic responses.

    • Eduard Hergenreider
    • Susanne Heydt
    • Stefanie Dimmeler
    Research
    Nature Cell Biology
    Volume: 14, P: 249-256

  • Structures of budding yeast RNA polymerase I in a catalytically active conformation are presented and confirmed by visualizing processive transcription along ribosomal DNA genes; they support a general model for transcription elongation in which contracted and expanded polymerase conformations are associated with active and inactive states, respectively.

    • Simon Neyer
    • Michael Kunz
    • Achilleas S. Frangakis
    Research
    Nature
    Volume: 540, P: 607-610