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Nature Genetics (1)

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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Cytokine-induced regulatory changes in human pancreatic islets illustrate the β-cell chromatin dynamics in response to a proinflammatory environment and implicate a role for islet enhancers in type 1 diabetes.

Mireia Ramos-Rodríguez
Helena Raurell-Vila
Lorenzo Pasquali
Research01 Nov 2019
Nature Genetics

Volume: 51, P: 1588-1595

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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

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