Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–2 of 2 results
Advanced filters: Author: Maria Rodriguez-Rios Clear advanced filters

  • Structure-based drug discovery of cereblon (CRBN)-recruiting protein degraders has been to date challenging due to limitations with current constructs for recombinant protein expression. In this work, the authors design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders.

    • Alena Kroupova
    • Valentina A. Spiteri
    • Alessio Ciulli
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Cathepsin D (CatD) is an aspartic acid protease involved in the immune response of macrophages to bacterial infection, and the development of pH insensitive CatD probes is vital in order to detect its activity across multiple cellular components. Here, the authors develop a water soluble and pH insensitive FRET-based fluorescent probe for the sensitive detection of CatD.

    • Maria Rodriguez-Rios
    • Brian J. McHugh
    • Mark Bradley
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-8