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Showing 51–100 of 525 results

Advanced filters: Author: Mark Watson Clear advanced filters

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

Stephen M. Hedrick
Ellen A. Nielsen
Mark M. Davis
Research08 Mar 1984
Nature

Volume: 308, P: 153-158
Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads

Assembly of haplotype-resolved human genomes is achieved by combining short and long reads.

David Porubsky
Peter Ebert
Tobias Marschall
ResearchOpen Access07 Dec 2020
Nature Biotechnology

Volume: 39, P: 302-308
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
In utero nanoparticle delivery for site-specific genome editing

The correction of genetic defects in utero could allow for improved outcomes of gene therapy. Here, the authors demonstrate safe delivery of nanoparticles to fetal mouse tissues, and show that nanoparticles containing peptide nucleic acids to edit the beta-globin gene are effective in a mouse model of beta-thalassemia.

Adele S. Ricciardi
Raman Bahal
W. Mark Saltzman
ResearchOpen Access26 Jun 2018
Nature Communications

Volume: 9, P: 1-11
The cost of recovering Australia’s threatened species

An estimated AU$583 billion per year cost of in situ recovery of terrestrial and freshwater species in Australia, including through habitat restoration and retention and management of invasive species, is not an expected conservation budget, but exemplifies the severe cost of nature declines.

April E. Reside
Josie Carwardine
James E. M. Watson
Research23 Dec 2024
Nature Ecology & Evolution

Volume: 9, P: 425-435
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells

Lan et al. report RNA structure ensembles across the entire SARSCoV-2 genome in infected human cells at single nucleotide resolution. They find alternative RNA conformations critical for promoting near-native frameshifting rates in ORF1ab.

Tammy C. T. Lan
Matty F. Allan
Silvi Rouskin
ResearchOpen Access02 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Alarm Pheromone and Avoidance Conditioning in Goldfish, Carassius auratus

G. McA. KIMBRELL
MARK R. WEINROTT
DEBORAH SANGSTON
Research21 Feb 1970
Nature

Volume: 225, P: 754
Predictors of COVID-19 epidemics in countries of the World Health Organization African Region

A new study from the WHO African Region identifies features of countries that predict timing of the first case and the per capita mortality rate for the first and second waves of the COVID-19 epidemics.

Feifei Zhang
Humphrey Karamagi
Mark E. J. Woolhouse
ResearchOpen Access03 Sept 2021
Nature Medicine

Volume: 27, P: 2041-2047
Bayesian refinement of association signals for 14 loci in 3 common diseases

Peter Donnelly and colleagues report fine mapping of 14 susceptibility loci in 8,000 cases and controls for type 2 diabetes, coronary artery disease and Graves' disease. They apply a new Bayesian method for analysis of fine-mapping data sets, using this to define sets of SNPs likely to contain causal disease-associated variants.

Julian B Maller
Gilean McVean
Peter Donnelly
Research28 Oct 2012
Nature Genetics

Volume: 44, P: 1294-1301
Back to the roots of botany in China

Mark F. Watson
Books & Arts03 Apr 1997
Nature

Volume: 386, P: 455-456
3D RNA-scaffolded wireframe origami

Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold messenger and ribosomal RNA into 3D polyhedral structures.

Molly F. Parsons
Matthew F. Allan
Mark Bathe
ResearchOpen Access24 Jan 2023
Nature Communications

Volume: 14, P: 1-14
Controllable valley splitting in silicon quantum devices

Srijit Goswami
K. A. Slinker
Mark A. Eriksson
Research10 Dec 2006
Nature Physics

Volume: 3, P: 41-45
The cell-cycle regulated transcription factor B-Myb is phosphorylated by Cyclin A/Cdk2 at sites that enhance its transactivation properties

Mark K Saville
Roger J Watson
Research24 Nov 1998
Oncogene

Volume: 17, P: 2679-2689
Mitigation of SARS-CoV-2 transmission at a large public university

Safely opening university campuses has been a major challenge during the COVID-19 pandemic. Here, the authors describe a program of public health measures employed at a university in the United States which, combined with other non-pharmaceutical interventions, allowed the university to stay open in fall 2020 with limited evidence of transmission.

Diana Rose E. Ranoa
Robin L. Holland
Martin D. Burke
ResearchOpen Access09 Jun 2022
Nature Communications

Volume: 13, P: 1-16
Localization of an ataxia-telangiectasia gene to chromosome 11q22–23

Richard A. Gatti
Izzet Berkel
Freda Yoder
Research08 Dec 1988
Nature

Volume: 336, P: 577-580
A closely linked genetic marker for cystic fibrosis

Ray White
Scott Woodward
George Vande Woude
Research28 Nov 1985
Nature

Volume: 318, P: 382-384
Age-associated defect in ADCC response to COVID-19 vaccine

Benjamin L. Sievers
Mazharul Altaf
Ravindra K. Gupta
ResearchOpen Access01 Jul 2025
npj Vaccines

Volume: 10, P: 1-9
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

Genetic analyses in a cohort of patients with melanoma receiving immunotherapy reveal that variants in IL7 are associated with immune-related adverse events and highlight the role of B cells in mediating toxicity.

Chelsea A. Taylor
Robert A. Watson
Benjamin P. Fairfax
ResearchOpen Access16 Dec 2022
Nature Medicine

Volume: 28, P: 2592-2600
Multi-level patterning nucleic acid photolithography

Increasing the complexity of engineered nucleic acid constructs and interfacing the microscopic with the macroscopic requires a multifaceted and programmable fabrication approach. Here the authors demonstrate multi-level photolithographic patterning for highly complex patterns at micrometer resolution.

Kathrin Hölz
Erika Schaudy
Mark M. Somoza
ResearchOpen Access23 Aug 2019
Nature Communications

Volume: 10, P: 1-8
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
High-potency ligands for DREADD imaging and activation in rodents and monkeys

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREADD radiotracer for imaging purposes.

Jordi Bonaventura
Mark A. G. Eldridge
Michael Michaelides
ResearchOpen Access11 Oct 2019
Nature Communications

Volume: 10, P: 1-12
Alteration of c-myc chromatin structure by avian leukosis virus integration

William Schubach
Mark Groudine
Research23 Feb 1984
Nature

Volume: 307, P: 702-708
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

Annadora J. Bruce
Warren Boling
Mark P. Mattson
Research01 Jul 1996
Nature Medicine

Volume: 2, P: 788-794
Arthropod fossil data increase congruence of morphological and molecular phylogenies

The phylogenetic relationship among different arthropod groups remains unclear. Here Legg et al. present a refined Arthropoda phylogeny based on extinct and extant data, in which Crustacea is paraphyletic with respect to Hexapoda.

David A. Legg
Mark D. Sutton
Gregory D. Edgecombe
Research30 Sept 2013
Nature Communications

Volume: 4, P: 1-7
TiSe₂ is a band insulator created by lattice fluctuations, not an excitonic insulator

Dimitar Pashov
Ross E. Larsen
Mark van Schilfgaarde
ResearchOpen Access26 May 2025
npj Computational Materials

Volume: 11, P: 1-9
Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis

EDI048 is a gastrointestinal-targeted Cryptosporidium PI(4)K inhibitor that undergoes a predictable metabolism and limits systemic exposure without compromising its anti-parasitic activity.

Ujjini H. Manjunatha
Suresh B. Lakshminarayana
Thierry T. Diagana
ResearchOpen Access08 Oct 2024
Nature Microbiology

Volume: 9, P: 2817-2835
A druggable copper-signalling pathway that drives inflammation

Cellular uptake of copper(ii) by CD44 has a key role in regulating cellular plasticity via copper(ii)-dependent downstream signalling events.

Stéphanie Solier
Sebastian Müller
Raphaël Rodriguez
ResearchOpen Access26 Apr 2023
Nature

Volume: 617, P: 386-394
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage

Using single-molecule magnetic tweezers and biochemical methods, Naqvi et al. revealed how CRISPR–Cas12a regulates the DNA cleavage rate through a conserved stacking interaction between the R-loop and the W355 residue and the sequence of the CRISPR RNA 3′ end.

Mohsin M. Naqvi
Laura Lee
Mark D. Szczelkun
ResearchOpen Access14 Jul 2022
Nature Chemical Biology

Volume: 18, P: 1014-1022
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
The follies of ancestor worship

Can we identify fossil ancestors of species alive today? Dr Mark Siddall contends that this is impossible and that the use of stratigraphic data when assembling phylogenies is thus unsupportable.

Mark Siddall
Comments & Opinion19 Nov 1998
Nature

P: 1-4
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

Domenico Accili
John Drago
Heiner Westphal
Research01 Jan 1996
Nature Genetics

Volume: 12, P: 106-109
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

Carol J. Thiele
C. Patrick Reynolds
Mark A. Israel
Research31 Jan 1985
Nature

Volume: 313, P: 404-406
Stabilization of protein structure by interaction of α-helix dipole with a charged side chain

Das̆a S˘ali
Mark Bycroft
Alan R. Fersht
Research20 Oct 1988
Nature

Volume: 335, P: 740-743
Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes

Patients’ selection is particularly important in cancer treatment. Here the authors present a proof-of-principle methodology that could be potentially important in assisting therapeutic decisions in the treatment of breast cancer patients.

Valeriy Domenyuk
Zoran Gatalica
David Spetzler
ResearchOpen Access23 Mar 2018
Nature Communications

Volume: 9, P: 1-9
Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

In this clinical trial, the authors show that a 5-day molnupiravir treatment reduces SARS-CoV-2 viral load in at-risk outpatients by day 5 but mostly fails to clear virus, leads to lower spike antibody response by day 14 and higher virus mutation rates.

Joseph F. Standing
Laura Buggiotti
Francis Yongblah
ResearchOpen Access23 Feb 2024
Nature Communications

Volume: 15, P: 1-14
A general approach to single-nucleotide polymorphism discovery

Gabor T. Marth
Ian Korf
Warren R. Gish
Research01 Dec 1999
Nature Genetics

Volume: 23, P: 452-456
Assembly of 43 human Y chromosomes reveals extensive complexity and variation

De novo assemblies of 43 Y chromosomes spanning 182,900 years of human evolution reveal considerable diversity in the size and structure of the human Y chromosome.

Pille Hallast
Peter Ebert
Charles Lee
Research23 Aug 2023
Nature

Volume: 621, P: 355-364
ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ

ChromEMT combines a fluorescent DNA binding dye that selectively enhances DNA and nucleosomes in electron microscopy with multi-tilt tomography, to enable the imaging and reconstruction of nuclear chromatin ultrastructure and 3D organization.

Horng D. Ou
Sebastien Phan
Clodagh C. O’Shea
Protocols29 Nov 2024
Nature Protocols

Volume: 20, P: 934-966
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

Daniel Taliun
Daniel N. Harris
Gonçalo R. Abecasis
ResearchOpen Access10 Feb 2021
Nature

Volume: 590, P: 290-299
Role of nanoscale antigen organization on B-cell activation probed using DNA origami

DNA origami allows the precise spatial patterning of antigens to investigate the impact of antigen spacing and arrangement on B-cell activation in vitro, which is important for the design of efficient vaccination strategies.

Rémi Veneziano
Tyson J. Moyer
Mark Bathe
Research29 Jun 2020
Nature Nanotechnology

Volume: 15, P: 716-723
A high observed substitution rate in the human mitochondrial DNA control region

Thomas J. Parsons
David S. Muniec
Mitchell M. Holland
Research01 Apr 1997
Nature Genetics

Volume: 15, P: 363-368
A systematic search for RNA structural switches across the human transcriptome

SwitchSeeker combines computational and experimental techniques to identify functional RNA structural switches. Applied to the human transcriptome, it identified a novel RNA switch in the 3ʹUTR of RORC, linked to nonsense-mediated decay.

Matvei Khoroshkin
Daniel Asarnow
Hani Goodarzi
ResearchOpen Access16 Jul 2024
Nature Methods

Volume: 21, P: 1634-1645
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

Evidence for a single microRNA (miRNA) that can efficiently differentiate multipotent stem cells into a specific lineage or regulate direct reprogramming of cells into an alternative cell fate has been elusive. Two miRNAs, miR-145 and miR-143, are now shown to be co-transcribed in multipotent cardiac progenitors before becoming localized to smooth muscle cells. miR-145 was found to be necessary for myocardin-induced reprogramming of adult fibroblasts and sufficient to induce differentiation of multipotent neural crest stem cells.

Kimberly R. Cordes
Neil T. Sheehy
Deepak Srivastava
Research05 Jul 2009
Nature

Volume: 460, P: 705-710
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

Andrew W. Murray
Mark J. Solomon
Marc W. Kirschner
Research25 May 1989
Nature

Volume: 339, P: 280-286
Structural basis for CRISPR RNA-guided DNA recognition by Cascade

The CRISPR system is a prokaryotic immune system that depends on the Cascade protein complex and small guide RNAs (crRNAs). The Cascade complex, loaded with crRNA, is now characterized, the overall architecture of Cascade deduced, and the complex found to identify targets by formation of an R loop between the crRNA and dsDNA.

Matthijs M Jore
Magnus Lundgren
Stan J J Brouns
Research03 Apr 2011
Nature Structural & Molecular Biology

Volume: 18, P: 529-536
The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

Jeffrey R. Huth
Carole A. Bewley
G. Marius Clore
Research01 Aug 1997
Nature Structural Biology

Volume: 4, P: 657-665
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

miRNAs are incorporated into ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs) to exert RNA interference. Here the authors show that translation initiation factor eIF1A interacts with the RISCs component Ago2 to promote miR-451 biogenesis and RNA interference.

Tingfang Yi
Haribabu Arthanari
Gerhard Wagner
Research28 May 2015
Nature Communications

Volume: 6, P: 1-11
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.

Usman A. Tahir
Daniel H. Katz
Robert E. Gerszten
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-16

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