Nature Search

Real-life behavioral and neural circuit markers of physical activity as a compensatory mechanism for social isolation

Physical activity has the potential to combat the negative mental health effects of social isolation. Its benefit is particularly high in people at increased neural and psychological risk for affective disorders.

Anastasia Benedyk
Markus Reichert
Heike Tost
ResearchOpen Access19 Feb 2024
Nature Mental Health

Volume: 2, P: 337-342
Allotype-linked genetic control of a polymorphic V_H framework determinant on mouse T-helper cell receptors

Yinon Ben Neriah
David Givol
Klaus Eichmann
Research22 May 1980
Nature

Volume: 285, P: 257-259
Temporal BMP4 effects on mouse embryonic and extraembryonic development

Temporally dynamic extraembryonic and embryonic BMP4 signalling shapes mouse embryo lineage choices.

Ron Hadas
Hernan Rubinstein
Yonatan Stelzer
ResearchOpen Access18 Sept 2024
Nature

Volume: 634, P: 652-661
Human islets contain four distinct subtypes of β cells

Dysfunction or loss of insulin-secreting β cells in the pancreas is a hallmark of diabetes. Here, Dorrell et al.identify four subpopulations of β cells in humans, which differ in gene expression and insulin secretion kinetics, and the abundance of which is altered in patients with type 2 diabetes.

Craig Dorrell
Jonathan Schug
Markus Grompe
ResearchOpen Access11 Jul 2016
Nature Communications

Volume: 7, P: 1-9
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I

Markus Grompe
Sven Lindstedt
Milton Finegold
Research01 Aug 1995
Nature Genetics

Volume: 10, P: 453-460
Hybrid soliton dynamics in liquid-core fibres

Here, Chemnitz et al. report experimental evidence for hybrid solitons – a type of solitary wave, which emerges as a result of a strong non-instantaneous nonlinear response in CS₂-filled liquid-core optical fibres, demonstrating efficient soliton-driven supercontinuum generation.

Mario Chemnitz
Martin Gebhardt
Markus A. Schmidt
ResearchOpen Access29 Jun 2017
Nature Communications

Volume: 8, P: 1-11
Rapid rotation of flagellar bundles in swimming bacteria

Graeme Lowe
Markus Meister
Howard C. Berg
Research18 Feb 1987
Nature

Volume: 325, P: 637-640
The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications

Epitope tags are widely used in various applications, but often lack versatility. Here, the authors introduce a small, alpha helical tag, which is recognized by a high affinity nanobody and can be used in a range of different applications, from protein purification to super-resolution imaging and in vivo detection of proteins.

Hansjörg Götzke
Markus Kilisch
Steffen Frey
ResearchOpen Access27 Sept 2019
Nature Communications

Volume: 10, P: 1-12
Young athletes’ mental well-being is associated with smartphone social networking application usage and moderated by performance level and app type

Radha Fiedler
Jahan Geber
Michael Kellmann
ResearchOpen Access07 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus

Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament anchorage of desmosomes.

Anna M. Sigmund
Markus Winkler
Jens Waschke
ResearchOpen Access09 Jan 2023
Nature Communications

Volume: 14, P: 1-17
Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines

Oxidative stress is associated with cardiovascular and neurodegenerative diseases. Here the authors show studies of transgenic chemogenetic mouse lines that develop sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress.

Shambhu Yadav
Markus Waldeck-Weiermair
Thomas Michel
ResearchOpen Access29 May 2023
Nature Communications

Volume: 14, P: 1-14
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α₁-antitrypsin (α₁AT) as SARS-CoV-2 inhibitor and show that α₁AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.

Lukas Wettstein
Tatjana Weil
Jan Münch
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism

Phospholipase D3 polymorphisms are linked to late-onset Alzheimer’s disease but the mechanisms are not understood. Van Acker and colleagues show that Phospholipase D3 processes mitochondrial DNA in lysosomes to maintain lysosomal homeostasis and proper degradation of the amyloid precursor protein.

Zoë P. Van Acker
Anika Perdok
Wim Annaert
ResearchOpen Access24 May 2023
Nature Communications

Volume: 14, P: 1-21
Mapping protein interactions in the active TOM-TIM23 supercomplex

The TOM and TIM23 complexes facilitate the transport of nuclear-encoded proteins into the mitochondrial matrix. Here, the authors use a stalled client protein to purify the translocation supercomplex and gain insight into the TOM-TIM23 interface and the mechanism of protein handover from the TOM to the TIM23 complex.

Ridhima Gomkale
Andreas Linden
Peter Rehling
ResearchOpen Access29 Sept 2021
Nature Communications

Volume: 12, P: 1-17
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity

The authors present a public collection of 117 bacterial isolates from the pig gut, including the description of 38 novel taxa. Interesting functions discovered in these organisms include a new fucosyltransferease and sactipeptide-like molecules encoded by biosynthetic gene clusters.

David Wylensek
Thomas C. A. Hitch
Thomas Clavel
ResearchOpen Access15 Dec 2020
Nature Communications

Volume: 11, P: 1-26
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autophagy reduces fibroblast activation and ameliorates fibrotic tissue remodeling.

Ariella Zehender
Yi-Nan Li
Jörg H. W. Distler
ResearchOpen Access20 Jul 2021
Nature Communications

Volume: 12, P: 1-19
Detailed mapping of the complex fiber structure and white matter pathways of the chimpanzee brain

This resource presents a high-resolution diffusion MRI dataset of a chimpanzee brain, which should be useful for evolutionary studies of primate brain evolution.

Cornelius Eichner
Michael Paquette
Alfred Anwander
ResearchOpen Access03 Jun 2024
Nature Methods

Volume: 21, P: 1122-1130
EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia

The exosome is responsible for mRNA degradation, which is an important step in the regulation of gene expression. Here the authors report that homozygous missense mutations in the exosome subunit, EXOSC8, may cause neurodegenerative disease in infants through the dysregulation of myelin expression.

Veronika Boczonadi
Juliane S. Müller
Rita Horvath
ResearchOpen Access03 Jul 2014
Nature Communications

Volume: 5, P: 1-13
Common variation in FAM155A is associated with diverticulitis but not diverticulosis

Matthias C. Reichert
Juozas Kupcinskas
Frank Lammert
ResearchOpen Access03 Feb 2020
Scientific Reports

Volume: 10, P: 1-6
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca²⁺ channel–vesicle coupling

Coupling distances between synaptic vesicles and Ca²⁺ channels determine the efficacy of neurotransmission. Böhme et al. find that presynaptic scaffold complexes spatiotemporally control Unc13 isoforms to establish two independent release pathways at subsynaptic active zones: Unc13B defines nascent, loosely coupled synapses whereas Unc13A facilitates release at mature synapses by tight coupling between Ca²⁺ channels and synaptic vesicles.

Mathias A Böhme
Christina Beis
Stephan J Sigrist
Research15 Aug 2016
Nature Neuroscience

Volume: 19, P: 1311-1320
An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter

Niklas Wallstein
André Pampel
Harald E. Möller
ResearchOpen Access05 Feb 2025
Scientific Reports

Volume: 15, P: 1-19
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Puya Gharahkhani
Eric Jorgenson
Janey L. Wiggs
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit

The ribosome-assembly factor Mrt4 prevents untimely recruitment of the RNA-export receptor Mex67–Mtr2 to the nascent 60S ribosomal subunit, thereby ensuring appropriately timed nuclear export.

Anshuk Sarkar
Markus Pech
Ed Hurt
Research24 Oct 2016
Nature Structural & Molecular Biology

Volume: 23, P: 1074-1082
Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens

Complex clinical samples can be imaged with 25 nm resolution using a light-emitting-diode-based wide-field microscope.

Dominik Kylies
Marina Zimmermann
Victor G. Puelles
ResearchOpen Access10 Apr 2023
Nature Nanotechnology

Volume: 18, P: 336-342
Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

Plasmodium falciparum kinase PfCRK4 is a key regulator of DNA replication in schizonts, required both during the intraerythrocytic blood stage of malaria infection and for transmission.

Markus Ganter
Jonathan M. Goldberg
Manoj T. Duraisingh
Research17 Feb 2017
Nature Microbiology

Volume: 2, P: 1-9
Neural correlates of individual differences in affective benefit of real-life urban green space exposure

Tost et al. show that urban green space exposure improves well-being, particularly in people dwelling in relatively deprived areas and showing less prefrontal activity during emotion processing, a neural signature that is linked to mental health risk.

Heike Tost
Markus Reichert
Andreas Meyer-Lindenberg
Research29 Jul 2019
Nature Neuroscience

Volume: 22, P: 1389-1393
Mutations in PYCR1 cause cutis laxa with progeroid features

Stefan Mundlos and colleagues report the identification of mutations in PYCR1 that cause autosomal recessive cutis laxa. PYCR1 encodes an enzyme involved in proline metabolism and localizes to mitochondria.

Bruno Reversade
Nathalie Escande-Beillard
Uwe Kornak
Research02 Aug 2009
Nature Genetics

Volume: 41, P: 1016-1021
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
The importance of high quality real-life social interactions during the COVID-19 pandemic

Maximilian Monninger
Pascal-M. Aggensteiner
Nathalie E. Holz
ResearchOpen Access04 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Rüdiger Hehlmann
Astghik Voskanyan
J. Mayer
ResearchOpen Access07 May 2020
Leukemia

Volume: 34, P: 2074-2086
Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice

Alexander Perniss
Nadine Schmidt
Wolfgang Kummer
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-15
Structure and Distribution of an Unrecognized Interstitium in Human Tissues

Petros C. Benias
Rebecca G. Wells
Neil D. Theise
ResearchOpen Access27 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel
Jakob Armann
Ulrich Zügge
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
Ivor Lewis esophagectomy patients are particularly vulnerable to respiratory impairment - a comparison to major lung resection

Martin Reichert
Magdalena Schistek
Andreas Hecker
ResearchOpen Access14 Aug 2019
Scientific Reports

Volume: 9, P: 1-12
Real-time individual benefit from social interactions before and during the lockdown: the crucial role of personality, neurobiology and genes

Maximilian Monninger
Pascal-M. Aggensteiner
Nathalie E. Holz
ResearchOpen Access21 Jan 2022
Translational Psychiatry

Volume: 12, P: 1-10
Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations

Carolin F. Reichert
Micheline Maire
Christina Schmidt
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Pritesh Jain
Tyne Miller-Fleming
Peristera Paschou
ResearchOpen Access23 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-10
Correction: High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Rüdiger Hehlmann
Astghik Voskanyan
J. Mayer
Amendments and Corrections10 Sept 2020
Leukemia

Volume: 34, P: 2823

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