Nature Search

Functional receptor for GDNF encoded by the c-ret proto-oncogene

Miles Trupp
Ernest Arenas
Carlos F. Ibáñez
Research27 Jun 1996
Nature

Volume: 381, P: 785-789
Defects in enteric innervation and kidney development in mice lacking GDNF

José G. Pichel
Liya Shen
Heiner Westphal
Research04 Jul 1996
Nature

Volume: 382, P: 73-76
Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

Obesity is a global health challenge with an ongoing need for new medical treatments. Here, the authors show that artesunate, an FDA-approved treatment for severe malaria, can be repurposed for the treatment of obesity via GDF15/GFRAL signaling axis without overt side effects in mice and non-human primates.

Xuanming Guo
Pallavi Asthana
Hoi Leong Xavier Wong
ResearchOpen Access03 Feb 2024
Nature Communications

Volume: 15, P: 1-14
GDNF signalling through the Ret receptor tyrosine kinase

Pascale Durbec
Camelia V. Marcos-Gutierrez
Vassilis Pachnis
Research27 Jun 1996
Nature

Volume: 381, P: 789-793
Receptors identified for a weight regulator

The discovery of the receptors for the protein GDF15 suggests that it regulates food uptake through the emergency pathway — a neuronal circuit that causes weight loss in response to cancer, tissue damage and stress. See Letter p.255

Mart Saarma
Adrian Goldman
News & Views27 Sept 2017
Nature

Volume: 550, P: 195-197
The K⁺/Cl⁻ co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

Claudio Rivera
Juha Voipio
Kai Kaila
Research21 Jan 1999
Nature

Volume: 397, P: 251-255
GDNF is not required for catecholaminergic neuron survival in vivo

Glial cell line-derived neurotrophic factor (GDNF) is in clinical trials for treating Parkinson's disease. However, endogenous GDNF function in brain catecholaminergic neurons has remained controversial. The authors utilized three complementary conditional knock-out approaches during development and adulthood and found that GDNF is not required for the maintenance of the catecholaminergic neurons in mice.

Jaakko Kopra
Carolina Vilenius
Jaan-Olle Andressoo
Correspondence24 Feb 2015
Nature Neuroscience

Volume: 18, P: 319-322
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL

The GDF15–GFRAL axis is key for regulating energy homeostasis and body weight. Membrane-bound matrix metalloproteinase 14 is shown to negatively regulate GFRAL, whereas its downregulation protects against diet-induced obesity through increased GDF15 signaling.

Chi Fung Willis Chow
Xuanming Guo
Hoi Leong Xavier Wong
Research17 Feb 2022
Nature Metabolism

Volume: 4, P: 203-212
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

The discovery and purification of a new neurotrophic factor, conserved dopamine neurotrophic Factor (CDNF), is reported. Like the glial cell line-derived neurotrophic factor GDNF, CDNF can prevent degeneration of dopaminergic neurons in a rat model of Parkinson's disease.

Päivi Lindholm
Merja H. Voutilainen
Mart Saarma
Research05 Jul 2007
Nature

Volume: 448, P: 73-77
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Moliner et al. show that psychedelics directly bind to the BDNF receptor TrkB with high affinity and promote BDNF-mediated plasticity and antidepressant-like effects, whereas their hallucinogenic-like effects are independent of TrkB binding.

Rafael Moliner
Mykhailo Girych
Eero Castrén
ResearchOpen Access05 Jun 2023
Nature Neuroscience

Volume: 26, P: 1032-1041
A deep convolutional neural network approach for astrocyte detection

Ilida Suleymanova
Tamas Balassa
Peter Horvath
ResearchOpen Access27 Aug 2018
Scientific Reports

Volume: 8, P: 1-7
The GDNF family: Signalling, biological functions and therapeutic value

Matti S. Airaksinen
Mart Saarma
Reviews01 May 2002
Nature Reviews Neuroscience

Volume: 3, P: 383-394
The mouse soluble GFRα4 receptor activates RET independently of its ligand persephin

J Yang
P Runeberg-Roos
M Saarma
Research08 Jan 2007
Oncogene

Volume: 26, P: 3892-3898
Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

Emilia Galli
Taina Härkönen
Päivi Lindholm
ResearchOpen Access30 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Transgenic Potato Plants Expressing Mammalian 2′–5′ Oligoadenylate Synthetase are Protected From Potato Virus X Infection Under Field Conditions

Erkki Truve
Anu Aaspôllu
Mart Saarma
Research01 Sept 1993
Bio/Technology

Volume: 11, P: 1048-1052
Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage

Kuan-Yin Tseng
Vassilis Stratoulias
Hock-Kean Liew
ResearchOpen Access15 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-20
Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

Anni Herranen
Kuu Ikäheimo
Ulla Pirvola
ResearchOpen Access06 Feb 2020
Cell Death & Disease

Volume: 11, P: 1-12
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism

Päivi Lindholm
Mart Saarma
ReviewsOpen Access14 Dec 2021
Molecular Psychiatry

Volume: 27, P: 1310-1321
Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells

Annakaisa Haapasalo
Tommi Saarelainen
Eero Castrén
Research16 Feb 1999
Oncogene

Volume: 18, P: 1285-1296

Search

Functional receptor for GDNF encoded by the c-ret proto-oncogene

Defects in enteric innervation and kidney development in mice lacking GDNF

Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

GDNF signalling through the Ret receptor tyrosine kinase

Receptors identified for a weight regulator

The K⁺/Cl⁻ co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

GDNF is not required for catecholaminergic neuron survival in vivo

Body weight regulation via MT1-MMP-mediated cleavage of GFRAL

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

A deep convolutional neural network approach for astrocyte detection

The GDNF family: Signalling, biological functions and therapeutic value

The mouse soluble GFRα4 receptor activates RET independently of its ligand persephin

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

Transgenic Potato Plants Expressing Mammalian 2′–5′ Oligoadenylate Synthetase are Protected From Potato Virus X Infection Under Field Conditions

Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage

Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism

Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells

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