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Showing 1–9 of 9 results

Advanced filters: Author: Martin Marsala Clear advanced filters

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

Injection of AAV–shRNA below the pial surface of the spinal cord prevents onset or ameliorates progression in a mouse model of ALS, and achieves widespread delivery to the spinal cord and brain motor centers in adult pigs and non-human primates.

Mariana Bravo-Hernandez
Takahiro Tadokoro
Martin Marsala
Research23 Dec 2019
Nature Medicine

Volume: 26, P: 118-130
Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells

Short- and long-term cultures of human stem-cell-derived neurons reveal that a pattern of restricted selection of clustered protocadherin isoforms, pre-established in pluripotent cells, distinguishes immature from mature neurons.

Angels Almenar-Queralt
Daria Merkurjev
Ivan Garcia-Bassets
Research18 Nov 2019
Nature Genetics

Volume: 51, P: 1691-1701
McArdle disease: what do neurologists need to know?

Alejandro Lucia
Gisela Nogales-Gadea
Joaquín Arenas
Reviews01 Oct 2008
Nature Clinical Practice Neurology

Volume: 4, P: 568-577
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation

Stathmin-2 is lost in amyotrophic lateral sclerosis. Here the authors show that stathmin-2 has an essential role in the maintenance of axon structure, with its loss from adult motor neurons resulting in axonal collapse and muscle denervation.

Jone López-Erauskin
Mariana Bravo-Hernandez
Clotilde Lagier-Tourenne
Research23 Nov 2023
Nature Neuroscience

Volume: 27, P: 34-47
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1

Molecular and physiological phenotypes in mouse models of myotonic dystrophy type I can be sustainably reversed by CRISPR-mediated targeting of toxic RNA repeats.

Ranjan Batra
David A. Nelles
Gene W. Yeo
Research14 Sept 2020
Nature Biomedical Engineering

Volume: 5, P: 157-168
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

Muscle spasticity is a major problem for individuals with SCI. Now, Laurent Vinay and his colleagues report that downregulation of the potassium-chloride cotransporter in spinal cord motor neurons after SCI has a key role in the development of spasticity (pages 270–271).

Pascale Boulenguez
Sylvie Liabeuf
Laurent Vinay
Research28 Feb 2010
Nature Medicine

Volume: 16, P: 302-307
Human mutant huntingtin disrupts vocal learning in transgenic songbirds

The study of speech or vocal disorder resulting from neurological diseases lacks a model capable of recapitulating vocal learning. This study suggests that the vocal disorder associated with Huntington's disease is observed in transgenic zebra finches carrying the full-length human mutant huntingtin gene.

Wan-chun Liu
Jessica Kohn
Ramee Lee
Research05 Oct 2015
Nature Neuroscience

Volume: 18, P: 1617-1622
Biomimetic 3D-printed scaffolds for spinal cord injury repair

Fast scalable 3D bioprinting generates biocompatible and biomimetic scaffolds to precisely fit the geometries of spinal cord lesions, promote axonal regeneration, and support stem cell grafts to promote recovery from spinal cord injury in rodents.

Jacob Koffler
Wei Zhu
Mark H. Tuszynski
Research14 Jan 2019
Nature Medicine

Volume: 25, P: 263-269
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Induced pluripotent stem cells are shown to be useful for studying phenotypes relevant to familial and sporadic Alzheimer’s disease, even though it can take decades for the disease to manifest in patients.

Mason A. Israel
Shauna H. Yuan
Lawrence S. B. Goldstein
Research25 Jan 2012
Nature

Volume: 482, P: 216-220