Nature Search

Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids

Amy R. Bentley
Michael R. Brown
Ervin R. Fox
ResearchOpen Access20 Jun 2025
Translational Psychiatry

Volume: 15, P: 1-12
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Multi-cohort study identifies social determinants of systemic inflammation over the life course

Here, the authors explore the relationship between socioeconomic position (SEP) across the life course and inflammation in a multi-cohort study and show that educational attainment is most strongly related to inflammation, suggesting that socioeconomic disadvantage in young adulthood is independently associated with later life inflammation.

Eloïse Berger
Raphaële Castagné
Michelle Kelly-Irving
ResearchOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-10
Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals, confirming an association at the CHRNA5–CHRNA3 locus on 15q25 to smoking quantity. They use imputation based on 1,000 Genomes Project Pilot 1 data to refine the association at this locus.

Jason Z Liu
Federica Tozzi
Jonathan Marchini
Research25 Apr 2010
Nature Genetics

Volume: 42, P: 436-440
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Minimal phenotyping yields genome-wide association signals of low specificity for major depression

Genetic analyses of depression based on minimal phenotyping identify nonspecific genetic risk factors shared between major depressive disorder (MDD) and other psychiatric conditions, suggesting that this approach may have limited ability to identify pathways specific to MDD.

Na Cai
Joana A. Revez
Jonathan Flint
Research30 Mar 2020
Nature Genetics

Volume: 52, P: 437-447
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach

Payam S. Shabestari
Stefan Schoisswohl
Patrick Neff
ResearchOpen Access31 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
Reply to “Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression”

Francis J McMahon
Nirmala Akula
Thomas G Schulze
Correspondence28 Dec 2010
Nature Genetics

Volume: 43, P: 5
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family

Karl P. Schlingmann
Stefanie Weber
Martin Konrad
Research28 May 2002
Nature Genetics

Volume: 31, P: 166-170
Long-term changes in adiposity markers during and after antidepressant therapy in a community cohort

Jessica Mwinyi
Marie-Pierre F. Strippoli
Martin Preisig
ResearchOpen Access13 Aug 2024
Translational Psychiatry

Volume: 14, P: 1-13
A mega-analysis of genome-wide association studies for major depressive disorder

Stephan Ripke
Naomi R Wray
Patrick F Sullivan
Research03 Apr 2012
Molecular Psychiatry

Volume: 18, P: 497-511
Psychotropic-induced weight gain and telomere length: results from a one-year longitudinal study and a large population-based cohort

Marianna Piras
Jue Lin
Chin B. Eap
ResearchOpen Access15 Nov 2024
Translational Psychiatry

Volume: 14, P: 1-10
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

W J Peyrot
S H Lee
B W J H Penninx
Research28 Apr 2015
Molecular Psychiatry

Volume: 20, P: 735-743
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

Francis McMahon and colleagues report a meta-analysis of genome-wide association data sets for major mood disorders, including bipolar disorder and major depressive disorder.

Francis J McMahon
Nirmala Akula
Marcella Rietschel
Research17 Jan 2010
Nature Genetics

Volume: 42, P: 128-131
β-Arrestin2 influences the response to methadone in opioid-dependent patients

B Oneda
S Crettol
C B Eap
Research01 Jun 2010
The Pharmacogenomics Journal

Volume: 11, P: 258-266
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Jorim J. Tielbeek
Emil Uffelmann
Danielle Posthuma
Research25 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4453-4463
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Associations between antipsychotics-induced weight gain and brain networks of impulsivity

Claire Grosu
Paul Klauser
Chin B. Eap
ResearchOpen Access26 Mar 2024
Translational Psychiatry

Volume: 14, P: 1-9
Spatial analysis of 10-year predicted risk and incident atherosclerotic cardiovascular disease: the CoLaus cohort

Guillaume Jordan
David Ridder
Julien Vaucher
ResearchOpen Access27 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders

Xiao Xiao
Lu Wang
Ming Li
ResearchOpen Access11 Dec 2017
Translational Psychiatry

Volume: 7, P: 1-10
Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain

MRI data from over 1000 participants between the ages of 46 and 87 reveals that cardiovascular risk factors are associated with myelin loss and neuroinflammation in the brain

Olga Trofimova
Adeliya Latypova
Bogdan Draganski
ResearchOpen Access10 Apr 2023
Communications Biology

Volume: 6, P: 1-14
Integrated metabolism in sponge–microbe symbiosis revealed by genome-centered metatranscriptomics

Lucas Moitinho-Silva
Cristina Díez-Vives
Torsten Thomas
Research24 Mar 2017
The ISME Journal

Volume: 11, P: 1651-1666
CYP2C19 expression modulates affective functioning and hippocampal subiculum volume—a large single-center community-dwelling cohort study

Claire Grosu
Olga Trofimova
Chin B. Eap
ResearchOpen Access05 Aug 2022
Translational Psychiatry

Volume: 12, P: 1-7
Erratum: Meta-analysis of genome-wide association studies of anxiety disorders

T Otowa
K Hek
J M Hettema
Amendments and Corrections09 Feb 2016
Molecular Psychiatry

Volume: 21, P: 1485
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk

Amy E. Miles
Fernanda C. Dos Santos
Yuliya S. Nikolova
Research29 Sept 2021
Neuropsychopharmacology

Volume: 46, P: 2304-2311
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Liz Rietschel
Fabian Streit
Marcella Rietschel
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts

Giorgio Pistis
Yuri Milaneschi
Zoltán Kutalik
ResearchOpen Access04 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-11
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders

H Chang
N Hoshina
M Li
ResearchOpen Access10 Jan 2017
Molecular Psychiatry

Volume: 23, P: 400-412
Meta-analysis of genome-wide association studies of anxiety disorders

T Otowa
K Hek
J M Hettema
Research12 Jan 2016
Molecular Psychiatry

Volume: 21, P: 1391-1399
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

S H Witt
F Streit
M Rietschel
ResearchOpen Access20 Jun 2017
Translational Psychiatry

Volume: 7, P: e1155
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Amendments and Corrections18 May 2020
Molecular Psychiatry

Volume: 26, P: 5465

Search

Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Multi-cohort study identifies social determinants of systemic inflammation over the life course

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Identification of common genetic risk variants for autism spectrum disorder

Minimal phenotyping yields genome-wide association signals of low specificity for major depression

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach

Reply to “Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression”

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family

Long-term changes in adiposity markers during and after antidepressant therapy in a community cohort

A mega-analysis of genome-wide association studies for major depressive disorder

Psychotropic-induced weight gain and telomere length: results from a one-year longitudinal study and a large population-based cohort

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

β-Arrestin2 influences the response to methadone in opioid-dependent patients

Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Associations between antipsychotics-induced weight gain and brain networks of impulsivity

Spatial analysis of 10-year predicted risk and incident atherosclerotic cardiovascular disease: the CoLaus cohort

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders

Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain

Integrated metabolism in sponge–microbe symbiosis revealed by genome-centered metatranscriptomics

CYP2C19 expression modulates affective functioning and hippocampal subiculum volume—a large single-center community-dwelling cohort study

Erratum: Meta-analysis of genome-wide association studies of anxiety disorders

Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders

Meta-analysis of genome-wide association studies of anxiety disorders

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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