Nature Search

Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

Volume: 28, P: 1393-1403
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

P: 1-13
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

N. Sommer
P.-A. Löschmann
R. Martin
Research01 Mar 1995
Nature Medicine

Volume: 1, P: 244-248
Regulated Expression Allows High Level Production and Secretion of HIV-1 gp120 Envelope Glycoprotein in Drosophila Schneider Cells

Jeffery S. Culp
Hanne Johansen
Martin Rosenberg
Research01 Feb 1991
Bio/Technology

Volume: 9, P: 173-177
Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study

Artificial intelligence (AI) system is known to improve dermatologists’ diagnostic accuracy for melanoma. This group applies the eye-tracking technology on dermatologists when diagnosing dermoscopic images of melanomas and reports improved balanced diagnostic accuracy when using an X(explainable) AI system comparing to the standard one.

Tirtha Chanda
Sarah Haggenmueller
Titus J. Brinker
ResearchOpen Access21 May 2025
Nature Communications

Volume: 16, P: 1-10
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
The Normal Fetal Heart Rate Study: Analysis Plan

Martin Daumer PhD
Michael Scholz
K T M Schneider MD
ResearchOpen Access12 Nov 2007
Nature Precedings

P: 1
The Normal Fetal Heart Rate Study: Analysis Plan

Martin Daumer PhD
Michael Scholz
K T M Schneider MD
ResearchOpen Access17 Sept 2007
Nature Precedings

P: 1
Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
New Synthetic Antispasmodics

J. CYMERMAN-CRAIG
K. V. MARTIN
G. THORBURN
Research31 Jul 1954
Nature

Volume: 174, P: 231
Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes

Sarcoma is a highly heterogeneous disease, which can be caused by a large variety of mutations. Here, the authors utilise multi-omics to characterise a cohort of 1,340 sarcoma tissue specimens to identify key somatic mutations and identify immune subtypes.

Alex Soupir
Oscar E. Ospina
Andrew S. Brohl
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-11
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Simulation of intercalation and phase transitions in nano-porous, polycrystalline agglomerates

Simon Daubner
Marcel Weichel
Britta Nestler
ResearchOpen Access03 Jul 2025
npj Computational Materials

Volume: 11, P: 1-9
Unifying the analysis of bottom-up proteomics data with CHIMERYS

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by DDA, DIA or PRM, thus unifying the analysis of bottom-up proteomics data.

Martin Frejno
Michelle T. Berger
Mathias Wilhelm
ResearchOpen Access22 Apr 2025
Nature Methods

Volume: 22, P: 1017-1027
Inhibition of the ‘Condensing Enzyme’ of Aspergillus niger by Magnesium

C. V. RAMAKRISHNAN
S. M. MARTIN
Research31 Jul 1954
Nature

Volume: 174, P: 230-231
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery

Synthesizing the cellular proteome is demanding and finely regulated. Here, the authors show that mTORC1 cooperates with tRNA wobble modification to promote ribosomal protein synthesis, thus supporting the high translational demands of cell growth.

Julia Hermann
Toman Borteçen
Wilhelm Palm
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-19
A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification

Studying cilia in human neural development is key to understanding ciliopathies. Here, using stem cell-derived human and mouse spinal organoids, the authors reveal inter-species differences for ciliopathy genes and a role for cilia in human axial patterning.

Antonia Wiegering
Isabelle Anselme
Aline Stedman
ResearchOpen Access05 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Determination of the Hubble constant from observations of Cepheid variables in the galaxy M96

N. R. Tanvir
T. Shanks
D. R. T. Robinson
Research07 Sept 1995
Nature

Volume: 377, P: 27-31
ODIN: An Advanced Interface for the Curation of Biomedical Literature

Fabio Rinaldi
Simon Clematide
Therese Vachon
MultimediaOpen Access02 Nov 2010
Nature Precedings

P: 1
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Circadian regulation of mitochondrial uncoupling and lifespan

Disruption of different components of molecular circadian clocks has varying effects on health and lifespan of model organisms. Here the authors show that loss of period extends life in drosophila melanogaster.

Matt Ulgherait
Anna Chen
Mimi Shirasu-Hiza
ResearchOpen Access21 Apr 2020
Nature Communications

Volume: 11, P: 1-16
A New Model for Virus Ribonucleic Acid Replication

F. BROWN
S. J. MARTIN
Research27 Nov 1965
Nature

Volume: 208, P: 861-863
Thymus reactive IgM autoantibodies in normal mouse sera

W. JOHN MARTIN
SUE ELLEN MARTIN
Research24 Apr 1975
Nature

Volume: 254, P: 716-718
Effect of energetic ions on edge-localized modes in tokamak plasmas

Edge-localized plasma modes in a tokamak can damage its innermost wall. Simulations now show that fast ions can modify the spatio-temporal structure of these modes. These effects need to be considered in the optimization of control techniques.

J. Dominguez-Palacios
S. Futatani
M. Zuin
ResearchOpen Access06 Jan 2025
Nature Physics

Volume: 21, P: 43-51
Detection of intergalactic ionized helium absorption in a high-redshift quasar

P. Jakobsen
A. Boksenberg
F. Paresce
Research07 Jul 1994
Nature

Volume: 370, P: 35-39
LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance

Obesity induces insulin resistance and impairs insulin signaling, causing diabetes. Here, the authors show that BMP and LGR signaling mediate communication between muscle, neuronal, and adipose tissues to enhance insulin signaling, identifying LGR as key in protecting against insulin resistance.

Olga Kubrak
Anne F. Jørgensen
Kim Rewitz
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-22
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Intrinsic Limitations in the Use of Electroantennograms to Bioassay Male Pheromones in Lepidoptera

MARTIN C. BIRCH
Research03 Sept 1971
Nature

Volume: 233, P: 57-58
Linkage of the gene for cystinosis to markers on the short arm of chromosome 17

Geraldine A. McDowell
William A. Gahl
Christopher G. Mathew
Research01 Jun 1995
Nature Genetics

Volume: 10, P: 246-248
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Milestone in predicting core plasma turbulence: successful multi-channel validation of the gyrokinetic code GENE

Plasma turbulence is the main driver to deteriorate the performance of fusion power plants. This work presents an unprecedented comparison of plasma turbulence between experiment and simulation, proving that the gyrokinetic model GENE reached a high level of maturity to predict core turbulence.

Klara Höfler
Tobias Görler
S. Zoletnik
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions

RNA-binding proteins are present in mitotic structures, but their role in cell division is unclear. Here, the authors provide an atlas of RNA-dependent mitotic proteins. They identify AURKA, KIFC1, and TPX2 as RNA-binding proteins and show that RNA regulates their interactions and functions.

Varshni Rajagopal
Jeanette Seiler
Maïwen Caudron-Herger
ResearchOpen Access08 Mar 2025
Nature Communications

Volume: 16, P: 1-24
Reply to: An approach to the resolution of the dispute on collective atomic interactions

Nuno A. G. Bandeira
Ángel Martín Pendás
Cina Foroutan-Nejad
ResearchOpen Access30 Nov 2024
Nature Communications

Volume: 15, P: 1-4
Active galaxies: dragon hunting in Arizona

Martin Elvis
Andrew S. Wilson
News & Views01 Mar 1981
Nature

Volume: 290, P: 10-11
1-Amino-4-phenyl Pyridinium Chloride: a Potential Antihypertensive Agent

R. T. BRITTAIN
J. B. FARMER
A. C. RITCHIE
Research18 Feb 1967
Nature

Volume: 213, P: 731-732
Spatial extent of a Landauer residual-resistivity dipole in graphene quantified by scanning tunnelling potentiometry

Electron transport at the atom-level scale cannot be described by spatially averaged electric fields as it is in macroscopic systems. Here, the authors experimentally demonstrate the spatial extent of an atomically local scattering process that gives rise to resistivity in nanoscale devices.

Philip Willke
Thomas Druga
Martin Wenderoth
Research06 Mar 2015
Nature Communications

Volume: 6, P: 1-5
Ultrafast magnetization enhancement in metallic multilayers driven by superdiffusive spin current

Spin dynamics in magnetic materials can be driven by ultrafast light pulses, resulting in transient magnetization changes on femtosecond timescales. Rudolphet al. find that in magnetic trilayers the magnetization of one layer can be enhanced by superdiffusive spin currents from adjacent layers.

Dennis Rudolf
Chan La-O-Vorakiat
Peter M. Oppeneer
Research04 Sept 2012
Nature Communications

Volume: 3, P: 1-6
The peripheral myelin protein gene PMP–22 is contained within the Charcot–Marie–Tooth disease type 1A duplication

V. Timmerman
E. Nelis
C. Van Broeckhoven
Research01 Jun 1992
Nature Genetics

Volume: 1, P: 171-175
Room-temperature Tamm-plasmon exciton-polaritons with a WSe₂ monolayer

Thanks to their strong light-matter interaction, atomically thin transition metal dichalcogenides are ideal active materials for cavity quantum electrodynamics. Here, the authors embed a WSe₂monolayer within a Tamm-plasmon-polariton cavity, and observe exciton-polariton formation at room temperature.

Nils Lundt
Sebastian Klembt
Christian Schneider
ResearchOpen Access31 Oct 2016
Nature Communications

Volume: 7, P: 1-6
Observing chaos for quantum-dot microlasers with external feedback

Optoelectronic devices such as conventional semiconductor lasers are used to study the chaotic behaviour of nonlinear systems. Here chaos is observed for quantum-dot microlasers operating close to the quantum limit with potential for new directions in the study of chaos in quantum systems.

Ferdinand Albert
Caspar Hopfmann
Ido Kanter
Research21 Jun 2011
Nature Communications

Volume: 2, P: 1-5
Complete tomography of a high-fidelity solid-state entangled spin–photon qubit pair

Future quantum communication technologies require entanglement between stationary and flying qubits, in systems that are inherently scalable. To this end, De Greveet al.present full state tomography of a qubit pair formed by entangling a quantum dot spin and a photon, with a fidelity of over 90%.

Kristiaan De Greve
Peter L. McMahon
Yoshihisa Yamamoto
Research26 Jul 2013
Nature Communications

Volume: 4, P: 1-7
Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability

Chromothripsis (CT) is a type of genome instability which is prevalent in medulloblastoma with germline TP53 mutations (Li-Fraumeni syndrome, LFS). Here the authors combine single-cell genomic and transcriptomic analyses to reveal the clonal heterogeneity and functional consequences of CT in LFS medulloblastoma.

Petr Smirnov
Moritz J. Przybilla
Aurélie Ernst
ResearchOpen Access23 Nov 2024
Nature Communications

Volume: 15, P: 1-20
Permeability of Rat White Adipose Tissue Mitochondria to Citrate, Isocitrate and 2-Oxoglutarate

M. L. HALPERIN
B. H. ROBINSON
R. M. DENTON
Research27 Sept 1969
Nature

Volume: 223, P: 1369-1371
Activation of Raf-1 by 14-3-3 proteins

Wendy J. Fantl
Anthony J. Muslin
Lewis T. Williams
Research13 Oct 1994
Nature

Volume: 371, P: 612-614

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