Cargo is transported through the cell on microtubules, but the regulatory mechanism controlling release of dynactin-bound cargo from dynein is not known. Here, Jin et al.uncover roles for ADP-ribosylation factor-like 3 (Arl3) and dynein light chain LC8 in unloading cargo from microtubules.
- Mingyue Jin
- Masami Yamada
- Shinji Hirotsune
