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A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism

Endocytic control of receptor signaling is emerging as more complex than mere signal attenuation. Here, authors describe an interorganelle platform formed during EGFR endocytosis that allows communication between EGFR and mitochondrial metabolism.

Deborah Mesa
Elisa Barbieri
Sara Sigismund
ResearchOpen Access15 Jun 2024
Nature Communications

Volume: 15, P: 1-19
An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo

The authors have previously reported split-GFP-based contact site sensors (SPLICS) to document endoplasmic reticulum/mitochondria contact sites. Here they extend this work and develop a range of improved SPLICS sensors to detect single and multiple organelle contact sites at different distances.

Francesca Vallese
Cristina Catoni
Tito Calì
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-15
Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques

This protocol from Bonora et al. describes three imaging techniques for examining mitochondrial permeability transition (mPT) in living cells.

Massimo Bonora
Claudia Morganti
Paolo Pinton
Protocols12 May 2016
Nature Protocols

Volume: 11, P: 1067-1080
A novel methodology for large-scale phylogeny partition

Phylogenetic analysis is used to identify transmission chains, but no software is available for the automated partition of large phylogenies. Prosperiet al. apply a new search algorithm to identify transmission clusters within the phylogeny of HIV-1gene sequences linking molecular and epidemiological data.

Mattia C.F. Prosperi
Massimo Ciccozzi
Andrea De Luca
Research24 May 2011
Nature Communications

Volume: 2, P: 1-10
Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

Massimiliano Castellazzi
Simone Patergnani
Paolo Pinton
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-7
Molecular mechanisms and consequences of mitochondrial permeability transition

Mitochondrial permeability transition — mediated by the opening of the so-called mitochondrial permeability transition pore — causes abrupt flux of low molecular weight solutes across the generally impermeable inner mitochondrial membrane. Recent studies provide new insights into the molecular nature and mechanisms of the mitochondrial permeability transition pore and the physiological consequences of its opening.

Massimo Bonora
Carlotta Giorgi
Paolo Pinton
Reviews08 Dec 2021
Nature Reviews Molecular Cell Biology

Volume: 23, P: 266-285
The TDH–GCN5L1–Fbxo15–KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells

Donato et al. show that Fbxo15 targets acetylated KBP for degradation to limit mitochondrial expansion, whereas KBP accumulation promotes mitochondrial biogenesis in a Kif1Bα-dependent manner.

Valerio Donato
Massimo Bonora
Michele Pagano
Research20 Mar 2017
Nature Cell Biology

Volume: 19, P: 341-351
Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes

Massimo Bonora
Carlotta Giorgi
Paolo Pinton
Protocols10 Oct 2013
Nature Protocols

Volume: 8, P: 2105-2118
Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy

Ada Bertoli
Maria Chiara Sorbo
Maurizio Zazzi
ResearchOpen Access12 Jun 2018
Scientific Reports

Volume: 8, P: 1-11
Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

Mitochondrial dysfunction has a major role in the pathogenesis of multiple cardiovascular disorders. In this Review, Galluzzi and colleagues discuss the therapeutic potential of mitochondria-targeting agents in the treatment of cardiovascular disease, examine the obstacles that have limited their development thus far, and identify strategies for the development of these promising therapeutic tools.

Massimo Bonora
Mariusz R. Wieckowski
Lorenzo Galluzzi
Reviews03 Sept 2018
Nature Reviews Cardiology

Volume: 16, P: 33-55
Other bricks for the correct construction of the mitochondrial permeability transition pore complex

Giampaolo Morciano
Massimo Bonora
Paolo Pinton
NewsOpen Access23 Mar 2017
Cell Death & Disease

Volume: 8, P: e2698
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment

Sonia Missiroli
Mariasole Perrone
Carlotta Giorgi
Research30 Nov 2022
Cell Death & Differentiation

Volume: 30, P: 429-441
Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death

Erica Salaro
Alessia Rambaldi
Francesco Di Virgilio
ResearchOpen Access25 May 2016
Scientific Reports

Volume: 6, P: 1-13
TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry

Luigi Sbano
Massimo Bonora
Paolo Pinton
ResearchOpen Access13 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Mitochondrial DNA keeps you young

Massimo Bonora
Paolo Pinton
Comments & OpinionOpen Access24 Sept 2018
Cell Death & Disease

Volume: 9, P: 1-3
Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics

Justyna Janikiewicz
Jędrzej Szymański
Mariusz R. Wieckowski
ReviewsOpen Access28 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-12

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