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Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl

Combining structural, biochemical, cellular and in vivo assays, the authors uncover the mechanism for capture and multisite phosphorylation of lethal (2) giant larvae by the atypical protein kinase C and partitioning-defective protein 6, revealing the basis for their mutual antagonism underpinning cell polarity.

Christopher P. Earl
Mathias Cobbaut
Neil Q. McDonald
ResearchOpen Access06 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 729-739
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Primary cilia are cell organelles disrupted in developmental diseases and cancer. Here, the authors identify cilia regulators that generate a specific cilia membrane lipid, which may help to better understand diseases caused by mutations in PI3-kinase subunits.

Sarah E. Conduit
Wayne Pearce
Bart Vanhaesebroeck
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-21
Equivocal, explicit and emergent actions of PKC isoforms in cancer

This Review discusses protein kinase C (PKC) isoforms in cancer, in particular focusing on their functional properties in the context of tumour suppression or promotion, target validation, PKC pharmacology and therapeutic exploitation.

Peter J. Parker
Sophie J. Brown
Lisa Watson
Reviews11 Nov 2020
Nature Reviews Cancer

Volume: 21, P: 51-63
Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

Mathias Cobbaut
Rita Derua
Johan Van Lint
ResearchOpen Access20 Apr 2017
Scientific Reports

Volume: 7, P: 1-17
Protein kinase D2: a versatile player in cancer biology

Ninel Azoitei
Mathias Cobbaut
Thomas Seufferlein
Reviews20 Dec 2017
Oncogene

Volume: 37, P: 1263-1278

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Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Equivocal, explicit and emergent actions of PKC isoforms in cancer

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

Protein kinase D2: a versatile player in cancer biology

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