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Showing 1–2 of 2 results
Advanced filters: Author: Mathieu Chicard Clear advanced filters

  • Liquid biopsies enable minimally invasive applications for diagnosis and treatment monitoring. Here the authors analyse fragmentation patterns of circulating tumour DNA on multiple levels and develop a bioinformatic tool, LIQUORICE, to accurately detect and classify paediatric cancers with low mutational burden.

    • Peter Peneder
    • Adrian M. Stütz
    • Eleni M. Tomazou
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • John Maris, Jan Molenaar, Gudrun Schleiermacher and colleagues performed whole-genome sequencing of 23 paired diagnostic and relapsed neuroblastomas, showing enrichment for mutations in the RAS-MAPK signaling pathway. These mutations render neuroblastoma cell lines susceptible to MEK inhibition.

    • Thomas F Eleveld
    • Derek A Oldridge
    • John M Maris
    Research
    Nature Genetics
    Volume: 47, P: 864-871