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Showing 1–2 of 2 results
Advanced filters: Author: Matthew Ranaghan Clear advanced filters

  • The small molecule DNMDP acts as a velcrin by inducing complex formation between phosphodiesterase PDE3A and SLFN12, which kills cancer cells that express sufficient levels of both proteins. Here, the authors present the cryo-EM structure of the DNMDP-stabilized PDE3A-SLFN12 complex and show that SLFN12 is an RNase. PDE3A binding increases SLFN12 RNase activity, and SLFN12 RNase activity is required for DNMDP-mediated cancer cell killing.

    • Colin W. Garvie
    • Xiaoyun Wu
    • Heidi Greulich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a conformationally inactive state, and explain the distribution of PPM1D activating mutations in cancer.

    • Peter G. Miller
    • Murugappan Sathappa
    • Benjamin L. Ebert
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16